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The role of microRNA-21 in the onset and progression of cancer

A. Singh, AK. Singh, R. Giri, D. Kumar, R. Sharma, M. Valis, K. Kuca, N. Garg

. 2021 ; 13 (21) : 1885-1906. [pub] 20210930

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22011983

MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.

Citace poskytuje Crossref.org

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$a Sharma, Rohit $u Department of Rasa Shastra & Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India $1 https://orcid.org/0000000236823573
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$a Valis, Martin $u Department of Neurology, Faculty of Medicine in Hradec Kralove & University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, 50003, Czech Republic
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