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Synthesis of [13 C6 ]-ibrutinib
M. Kriegelstein, M. Hroch, A. Marek
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
34478181
DOI
10.1002/jlcr.3944
Knihovny.cz E-resources
- MeSH
- Adenine analogs & derivatives chemistry MeSH
- Bromobenzenes chemistry MeSH
- Protein Kinase Inhibitors chemistry MeSH
- Carbon Isotopes chemistry MeSH
- Piperidines chemistry MeSH
- Chemistry Techniques, Synthetic methods MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Convenient and straightforward synthesis of ibrutinib labeled by carbon-13 isotope is reported. Isotopically labeled building block is introduced in the last step of reaction sequence affording sufficient isolated yield (7%) of [13 C6 ]-ibrutinib calculated towards starting commercially available [13 C6 ]-bromobenzene.
Faculty of Medicine in Hradec Kralove Charles University Hradec Kralove Czech Republic
Institute of Organic Chemistry and Biochemistry The Czech Academy of Sciences Prague Czech Republic
References provided by Crossref.org
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