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A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy
P. Krupa, M. Kanta, T. Hosszu, J. Soukup, P. Ryska, P. Dulicek, T. Cesak
Jazyk angličtina Země Nizozemsko
Typ dokumentu kazuistiky, časopisecké články
Grantová podpora
Q40 04
Progres
NLK
ProQuest Central
od 1998-06-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1998-06-01 do Před 1 rokem
- MeSH
- antikoagulancia MeSH
- lidé MeSH
- lumbosakrální krajina MeSH
- magnetická rezonanční tomografie MeSH
- pyrazoly škodlivé účinky MeSH
- pyridony škodlivé účinky MeSH
- spinální epidurální hematom * chemicky indukované diagnostické zobrazování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Spontaneous spinal epidural hematoma (SSEH) is a very rare clinical entity with potential diagnostic difficulties and which can result in severe neurological deficit. The etiology of this rare condition is largely not known, but with potential predisposition in patients on anticoagulation medication. This includes the novel anticoagulants with direct inhibition of the factor Xa mechanism (DOACs). These medications are supposed to have more predictable pharmacokinetics with fewer severe haemorrhagic adverse events in comparison with standard warfarin therapy. However, in the last few years, an increasing number of case reports have been published of haemorrhage into the central nervous system. We present a case of non-traumatic spinal epidural hematoma in the lumbar region in a patient on chronic apixaban therapy. To the best of our knowledge, it is the first described SSEH in the lumbar region associated with apixaban therapy.
Citace poskytuje Crossref.org
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- $a Krupa, Petr $u Department of Neurosurgery, Charles University Medical Faculty and Faculty Hospital, Hradec Králové, Czech Republic. petr.krupa@fnhk.cz $u Department of Neuroregeneration, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic. petr.krupa@fnhk.cz $1 https://orcid.org/0000000218327488
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- $a Spontaneous spinal epidural hematoma (SSEH) is a very rare clinical entity with potential diagnostic difficulties and which can result in severe neurological deficit. The etiology of this rare condition is largely not known, but with potential predisposition in patients on anticoagulation medication. This includes the novel anticoagulants with direct inhibition of the factor Xa mechanism (DOACs). These medications are supposed to have more predictable pharmacokinetics with fewer severe haemorrhagic adverse events in comparison with standard warfarin therapy. However, in the last few years, an increasing number of case reports have been published of haemorrhage into the central nervous system. We present a case of non-traumatic spinal epidural hematoma in the lumbar region in a patient on chronic apixaban therapy. To the best of our knowledge, it is the first described SSEH in the lumbar region associated with apixaban therapy.
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- $a Kanta, Martin $u Department of Neurosurgery, Charles University Medical Faculty and Faculty Hospital, Hradec Králové, Czech Republic
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