-
Something wrong with this record ?
Radical hysterectomy in early cervical cancer in Europe: characteristics, outcomes and evaluation of ESGO quality indicators
F. Boria, L. Chiva, V. Zanagnolo, D. Querleu, N. Martin-Calvo, ME. Căpîlna, A. Fagotti, A. Kucukmetin, C. Mom, G. Chakalova, A. Shamistan, M. Malzoni, F. Narducci, O. Arencibia, F. Raspagliesi, T. Toptas, D. Cibula, D. Kaidarova, MM. Meydanli, M....
Language English Country Great Britain
Document type Journal Article
NLK
ProQuest Central
from 2018-01-01 to 6 months ago
Health & Medicine (ProQuest)
from 2018-01-01 to 6 months ago
- MeSH
- Hysterectomy methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Uterine Cervical Neoplasms surgery MeSH
- Quality Indicators, Health Care standards MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
INTRODUCTION: Comprehensive updated information on cervical cancer surgical treatment in Europe is scarce. OBJECTIVE: To evaluate baseline characteristics of women with early cervical cancer and to analyze the outcomes of the ESGO quality indicators after radical hysterectomy in the SUCCOR database. METHODS: The SUCCOR database consisted of 1272 patients who underwent radical hysterectomy for stage IB1 cervical cancer (FIGO 2009) between January 2013 and December 2014. After exclusion criteria, the final sample included 1156 patients. This study first described the clinical, surgical, pathological, and follow-up variables of this population and then analyzed the outcomes (disease-free survival and overall survival) after radical hysterectomy. Surgical-related ESGO quality indicators were assessed and the accomplishment of the stated recommendations was verified. RESULTS: The mean age of the patients was 47.1 years (SD 10.8), with a mean body mass index of 25.4 kg/m2 (SD 4.9). A total of 423 (36.6%) patients had a previous cone biopsy. Tumor size (clinical examination) <2 cm was observed in 667 (57.7%) patients. The most frequent histology type was squamous carcinoma (794 (68.7%) patients), and positive lymph nodes were found in 143 (12.4%) patients. A total of 633 (54.8%) patients were operated by open abdominal surgery. Intra-operative complications occurred in 108 (9.3%) patients, and post-operative complications during the first month occurred in 249 (21.5%) patients, with bladder dysfunction as the most frequent event (119 (10.3%) patients). Clavien-Dindo grade III or higher complication occurred in 56 (4.8%) patients. A total of 510 (44.1%) patients received adjuvant therapy. After a median follow-up of 58 months (range 0-84), the 5-year disease-free survival was 88.3%, and the overall survival was 94.9%. In our population, 10 of the 11 surgical-related quality indicators currently recommended by ESGO were fully fulfilled 5 years before its implementation. CONCLUSIONS: In this European cohort, the rate of adjuvant therapy after radical hysterectomy is higher than for most similar patients reported in the literature. The majority of centers were already following the European recommendations even 5 years prior to the ESGO quality indicator implementations.
Amsterdam University Medical Centres Amsterdam Noord Holland Netherlands
Azienda Ospedaliero Universitaria di Bologna Policlinico SantOrsola Malpighi Bologna Italy
Bellvitge University Hospital L'Hospitalet de Llobregat Catalunya Spain
Clinic of Obstetrics and Gynecology Hospital San Gerardo Monza Italy
Clinica Universidad de Navarra Departamento de Ginecologia y Obstetricia Madrid Spain
Clinica Universidad de Navarra Departamento de Ginecologia y Obstetricia Pamplona Navarra Spain
Clinical Hospital Center Rijeka Rijeka Croatia
Clinical Hospital Center Zagreb Croatia
Department of Gynaecology LUMC Leiden Netherlands
Department of Gynecologíc Oncology Hospital Universitario La Paz Madrid Madrid Spain
Department of Gynecologic Oncology Universidad de Navarra Pamplona Navarra Spain
Department of Gynecological Oncology Radboudumc Nijmegen Netherlands
Department of Gynecology and Oncology Jagiellonian University Krakow Poland
Department of Gynecology Centre Oscar Lambret Lille France
Department of Gynecology Clinica Universitaria de Navarra Madrid Spain
Department of Gynecology Clinica Universitaria de Navarra Pamplona Navarra Spain
Department of Gynecology Instituto Português de Oncologia de Lisboa Lisboa Lisboa Portugal
Department of Medicine and Surgery University of Milan Bicocca Milano Italy
Department of Obstetrics and Gynecology Clinica Universidad de Navarra Madrid Spain
Department of Obstetrics and Gynecology School of Medicine
Department of Obstetrics and Gynecology Tampere University Hospital Tampere Finland
Department of Obstetrics and Gynecology University of Liege Liege Belgium
Department of Obstetrics and Gynecology University of Prague Prague Czech Republic
Department of Preventive Medicine and Public Health Universidad de Navarra Pamplona Spain
Department of Surgery Fondazione IRCCS Istituto Nazionale dei Tumori Milano Lombardia Italy
Department of Surgery Institut Bergonie Bordeaux France
Department of Surgery LISOD Israeli Oncological Hospital Kyiv region Ukraine
Emergency County Hospital Targu Mures Targu Mures Romania
General Hospital of Thessaloniki Papageorgiou Thessaloniki Central Macedonia Greece
Institut Curie Paris Île de France France
Instituto Português de Oncologia do Porto Francisco Gentil Porto Portugal
Istituto Europeo di Oncologia Milano Anognnn Italy
Kardinal Schwarzenberg'sches Krankenhaus Schwarzach Steiermark Austria
Lviv Oncology Center Lviv Ukraine
National Center of Oncology Baku Azerbaijan
North Estonia Medical Centre Tallinn Estonia
Oncogynecology Kazahskij Naucno Issledovatel'skij Institut Onkologii i Radiologii Almaty Kazakhstan
Queen Elizabeth Hospital Gateshead Gateshead UK
University Hospitals of Leicester NHS Trust Leicester Leicester UK
University Maternal Hospital Canary Islands Las Palma Spain
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22012247
- 003
- CZ-PrNML
- 005
- 20220506130526.0
- 007
- ta
- 008
- 220425s2021 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1136/ijgc-2021-002587 $2 doi
- 035 __
- $a (PubMed)34321289
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Boria, Felix $u Clinica Universidad de Navarra Departamento de Ginecologia y Obstetricia, Madrid, Spain $1 https://orcid.org/0000000247616190
- 245 10
- $a Radical hysterectomy in early cervical cancer in Europe: characteristics, outcomes and evaluation of ESGO quality indicators / $c F. Boria, L. Chiva, V. Zanagnolo, D. Querleu, N. Martin-Calvo, ME. Căpîlna, A. Fagotti, A. Kucukmetin, C. Mom, G. Chakalova, A. Shamistan, M. Malzoni, F. Narducci, O. Arencibia, F. Raspagliesi, T. Toptas, D. Cibula, D. Kaidarova, MM. Meydanli, M. Tavares, D. Golub, AM. Perrone, R. Poka, D. Tsolakidis, G. Vujić, MA. Jedryka, PLM. Zusterzeel, JJ. Beltman, F. Goffin, D. Haidopoulos, H. Haller, R. Jach, I. Yezhova, I. Berlev, M. Bernardino, R. Bharathan, M. Lanner, MM. Maenpaa, V. Sukhin, JG. Feron, R. Fruscio, K. Kukk, J. Ponce, M. Alonso-Espías, JA. Minguez, D. Vázquez-Vicente, N. Manzour, M. Jurado, T. Castellanos, E. Chacon, JL. Alcazar
- 520 9_
- $a INTRODUCTION: Comprehensive updated information on cervical cancer surgical treatment in Europe is scarce. OBJECTIVE: To evaluate baseline characteristics of women with early cervical cancer and to analyze the outcomes of the ESGO quality indicators after radical hysterectomy in the SUCCOR database. METHODS: The SUCCOR database consisted of 1272 patients who underwent radical hysterectomy for stage IB1 cervical cancer (FIGO 2009) between January 2013 and December 2014. After exclusion criteria, the final sample included 1156 patients. This study first described the clinical, surgical, pathological, and follow-up variables of this population and then analyzed the outcomes (disease-free survival and overall survival) after radical hysterectomy. Surgical-related ESGO quality indicators were assessed and the accomplishment of the stated recommendations was verified. RESULTS: The mean age of the patients was 47.1 years (SD 10.8), with a mean body mass index of 25.4 kg/m2 (SD 4.9). A total of 423 (36.6%) patients had a previous cone biopsy. Tumor size (clinical examination) <2 cm was observed in 667 (57.7%) patients. The most frequent histology type was squamous carcinoma (794 (68.7%) patients), and positive lymph nodes were found in 143 (12.4%) patients. A total of 633 (54.8%) patients were operated by open abdominal surgery. Intra-operative complications occurred in 108 (9.3%) patients, and post-operative complications during the first month occurred in 249 (21.5%) patients, with bladder dysfunction as the most frequent event (119 (10.3%) patients). Clavien-Dindo grade III or higher complication occurred in 56 (4.8%) patients. A total of 510 (44.1%) patients received adjuvant therapy. After a median follow-up of 58 months (range 0-84), the 5-year disease-free survival was 88.3%, and the overall survival was 94.9%. In our population, 10 of the 11 surgical-related quality indicators currently recommended by ESGO were fully fulfilled 5 years before its implementation. CONCLUSIONS: In this European cohort, the rate of adjuvant therapy after radical hysterectomy is higher than for most similar patients reported in the literature. The majority of centers were already following the European recommendations even 5 years prior to the ESGO quality indicator implementations.
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hysterektomie $x metody $7 D007044
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a ukazatele kvality zdravotní péče $x normy $7 D019984
- 650 _2
- $a výsledek terapie $7 D016896
- 650 _2
- $a nádory děložního čípku $x chirurgie $7 D002583
- 651 _2
- $a Evropa $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Chiva, Luis $u Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, Madrid, Spain lchiva@unav.es $1 https://orcid.org/0000000219083251
- 700 1_
- $a Zanagnolo, Vanna $u Istituto Europeo di Oncologia, Milano, Anognnn, Italy
- 700 1_
- $a Querleu, Denis $u Department of Surgery, Institut Bergonie, Bordeaux, France $1 https://orcid.org/0000000239844812
- 700 1_
- $a Martin-Calvo, Nerea $u Department of Preventive Medicine and Public Health, Universidad de Navarra, Pamplona, Spain
- 700 1_
- $a Căpîlna, Mihai Emil $u Emergency County Hospital Targu-Mures, Targu Mures, Romania
- 700 1_
- $a Fagotti, Anna $u Department of Woman, Child, and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
- 700 1_
- $a Kucukmetin, Ali $u Queen Elizabeth Hospital, Gateshead, Gateshead, UK
- 700 1_
- $a Mom, Constantijne $u Amsterdam University Medical Centres, Amsterdam, Noord-Holland, Netherlands
- 700 1_
- $a Chakalova, Galina $u University Oncologic Hospital, Sofia, Bulgaria
- 700 1_
- $a Shamistan, Aliyev $u National Center of Oncology, Baku, Azerbaijan
- 700 1_
- $a Malzoni, Mario $u Endoscopica Malzoni, Center for Advanced Endoscopic Gynecologic Surgery, Center for Advanced Endoscopic Gynecologic Surgery, Avellino, Italy
- 700 1_
- $a Narducci, Fabrice $u Department of Gynecology, Centre Oscar Lambret, Lille, France
- 700 1_
- $a Arencibia, Octavio $u University Maternal Hospital Canary Islands, Las Palma, Spain
- 700 1_
- $a Raspagliesi, Francesco $u Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia, Italy
- 700 1_
- $a Toptas, Tayfun $u Department of Gynecologic Oncology, Saglik Bilimleri University Antalya Research and Training Hospital, Antalya, Turkey $1 https://orcid.org/0000000267066915
- 700 1_
- $a Cibula, David $u Department of Obstetrics and Gynecology, University of Prague, Prague, Czech Republic
- 700 1_
- $a Kaidarova, Dilyara $u Oncogynecology, Kazahskij Naucno-Issledovatel'skij Institut Onkologii i Radiologii, Almaty, Kazakhstan
- 700 1_
- $a Meydanli, Mehmet Mutlu $u Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey $1 https://orcid.org/0000000167639720
- 700 1_
- $a Tavares, Mariana $u Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal
- 700 1_
- $a Golub, Dmytro $u Department of Surgery, LISOD - Israeli Oncological Hospital, Kyiv region, Ukraine
- 700 1_
- $a Perrone, Anna Myriam $u Azienda Ospedaliero-Universitaria di Bologna Policlinico SantOrsola-Malpighi, Bologna, Italy $1 https://orcid.org/0000000331404772
- 700 1_
- $a Poka, Robert $u Obstetrics and Gynecology, Unit of Gynecologic Oncology, Institute of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary $1 https://orcid.org/0000000318361579
- 700 1_
- $a Tsolakidis, Dimitrios $u General Hospital of Thessaloniki Papageorgiou, Thessaloniki, Central Macedonia, Greece
- 700 1_
- $a Vujić, Goran $u Clinical Hospital Center, Zagreb, Croatia
- 700 1_
- $a Jedryka, Marcin A $u Department of Oncological Gynecology, Uniwersytet Medyczny im Piastów Śląskich we Wrocławiu (Wroclaw Medical University), Wroclaw, Poland $1 https://orcid.org/0000000189350311
- 700 1_
- $a Zusterzeel, Petra L M $u Department of Gynecological Oncology, Radboudumc, Nijmegen, Netherlands
- 700 1_
- $a Beltman, Jogchum Jan $u Department of Gynaecology, LUMC, Leiden, Netherlands
- 700 1_
- $a Goffin, Frederic $u Department of Obstetrics and Gynecology, University of Liege, Liege, Belgium
- 700 1_
- $a Haidopoulos, Dimitrios $u Division of Gynecologic Oncology, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece
- 700 1_
- $a Haller, Herman $u Clinical Hospital Center Rijeka, Rijeka, Croatia
- 700 1_
- $a Jach, Robert $u Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland
- 700 1_
- $a Yezhova, Iryna $u Lviv Oncology Center, Lviv, Ukraine
- 700 1_
- $a Berlev, Igor $u North-Western State Medical University. N.N. Petrov Research Institute of Oncology, Saint-Petersburg, Saint-Petersburg, Russian Federation
- 700 1_
- $a Bernardino, Margarida $u Department of Gynecology, Instituto Português de Oncologia de Lisboa, Lisboa, Lisboa, Portugal
- 700 1_
- $a Bharathan, Rasiah $u University Hospitals of Leicester NHS Trust, Leicester, Leicester, UK
- 700 1_
- $a Lanner, Maximilian $u Kardinal Schwarzenberg'sches Krankenhaus, Schwarzach, Steiermark, Austria
- 700 1_
- $a Maenpaa, Minna M $u Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland
- 700 1_
- $a Sukhin, Vladyslav $u Department of Oncology, Radiology and Radiation Medicine, V N Karazin Kharkiv National University, Harkiv, Ukraine $u Department of Oncogynecology, Grigoriev Institute for Medical Radiology NAMS of Ukraine, Harkiv, Ukraine $1 https://orcid.org/0000000244033707
- 700 1_
- $a Feron, Jean-Guillaume $u Institut Curie, Paris, Île-de-France, France
- 700 1_
- $a Fruscio, Robert $u Department of Medicine and Surgery, University of Milan-Bicocca, Milano, Italy $u Clinic of Obstetrics and Gynecology, Hospital San Gerardo, Monza, Italy $1 https://orcid.org/0000000156882194
- 700 1_
- $a Kukk, Kersti $u North Estonia Medical Centre, Tallinn, Estonia
- 700 1_
- $a Ponce, Jordi $u Bellvitge University Hospital, L'Hospitalet de Llobregat, Catalunya, Spain
- 700 1_
- $a Alonso-Espías, María $u Department of Gynecologíc Oncology, Hospital Universitario La Paz, Madrid, Madrid, Spain
- 700 1_
- $a Minguez, Jose Angel $u Department of Gynecology, Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
- 700 1_
- $a Vázquez-Vicente, Daniel $u Department of Gynecology, Clinica Universitaria de Navarra, Madrid, Spain $1 https://orcid.org/0000000296185606
- 700 1_
- $a Manzour, Nabil $u Clinica Universidad de Navarra Departamento de Ginecologia y Obstetricia, Pamplona, Navarra, Spain $1 https://orcid.org/0000000246046042
- 700 1_
- $a Jurado, Matias $u Department of Gynecology, Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
- 700 1_
- $a Castellanos, Teresa $u Department of Gynecology, Clinica Universitaria de Navarra, Madrid, Spain
- 700 1_
- $a Chacon, Enrique $u Department of Gynecologic Oncology, Universidad de Navarra, Pamplona, Navarra, Spain $1 https://orcid.org/0000000186598602
- 700 1_
- $a Alcazar, Juan Luis $u Department of Obstetrics and Gynecology, School of Medicine; University of Navarra, Pamplona, Spain $1 https://orcid.org/0000000297000853
- 773 0_
- $w MED00009896 $t International journal of gynecological cancer : official journal of the International Gynecological Cancer Society $x 1525-1438 $g Roč. 31, č. 9 (2021), s. 1212-1219
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34321289 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220506130518 $b ABA008
- 999 __
- $a ok $b bmc $g 1789716 $s 1163448
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 31 $c 9 $d 1212-1219 $e 20210728 $i 1525-1438 $m International journal of gynecological cancer $n Int J Gynecol Cancer $x MED00009896
- LZP __
- $a Pubmed-20220425
