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The potential of miR-499 plasmatic level as a biomarker of obstructive sleep apnea syndrome
D. Slouka, J. Windrichova, H. Rezackova, K. Houfkova, R. Kucera, V. Cerna, T. Kostlivy, O. Topolcan, M. Pesta
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
PubMed Central
from 2015 to 1 year ago
ProQuest Central
from 2007-06-01 to 2021-01-31
Health & Medicine (ProQuest)
from 2007-06-01 to 2021-01-31
Public Health Database (ProQuest)
from 2007-06-01 to 2021-01-31
PubMed
34289701
DOI
10.2217/bmm-2020-0826
Knihovny.cz E-resources
- MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Logistic Models MeSH
- MicroRNAs genetics MeSH
- Multivariate Analysis MeSH
- Sleep Apnea, Obstructive blood diagnosis genetics MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Gene Expression Regulation MeSH
- ROC Curve MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Background: Obstructive sleep apnea syndrome (OSAS) is one of the most common sleep-related breathing disorders. The aim of this study was to improve diagnostics in OSAS using blood circulating biomarkers. We consider the potential of cardiac-specific miRNAs in the diagnosis and risk assessment of cardiovascular complications. Materials & methods: Plasmatic levels of miR-1-3p, miR-133a-3p and miR-499a-5p were measured by reverse transcription-PCR and compared with the clinical status of OSAS patients and controls. Results: The level of miR-499 was higher (p = 0.0343) in OSAS patients (mean expression: 0.00561) compared with the controls (mean expression: 0.00003), using the multivariate logistic regression. Conclusion: The role of miR-499 in gene expression regulation during hypoxia and our findings indicate that miR-499 could be a new diagnostic biomarker for OSAS.
References provided by Crossref.org
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