• Something wrong with this record ?

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

M. Pazdernik, H. Bedanova, Z. Chen, J. Kautzner, V. Melenovsky, I. Malek, A. Slavcev, M. Bartonova, V. Karmazin, T. Eckhardt, A. Tomasek, E. Ozabalova, T. Kovarnik, P. Wohlfahrt, M. Sonka

. 2021 ; 65 (-) : 101340. [pub] 20201015

Language English Country Netherlands

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22012501

Grant support
R01 EB004640 NIBIB NIH HHS - United States

INTRODUCTION: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). METHODS: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. RESULTS: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. CONCLUSION: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22012501
003      
CZ-PrNML
005      
20220506130254.0
007      
ta
008      
220425s2021 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.trim.2020.101340 $2 doi
035    __
$a (PubMed)33069814
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Pazdernik, Michal $u Department of Cardiology, IKEM, Prague, Czech Republic; Department of Cardiology, 2nd Medical School, Charles University, University Hospital Motol, Prague, Czech Republic. Electronic address: Michal.Pazdernik@email.cz
245    10
$a Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis / $c M. Pazdernik, H. Bedanova, Z. Chen, J. Kautzner, V. Melenovsky, I. Malek, A. Slavcev, M. Bartonova, V. Karmazin, T. Eckhardt, A. Tomasek, E. Ozabalova, T. Kovarnik, P. Wohlfahrt, M. Sonka
520    9_
$a INTRODUCTION: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). METHODS: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. RESULTS: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. CONCLUSION: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.
650    _2
$a alografty $7 D064591
650    _2
$a rejekce štěpu $x diagnóza $7 D006084
650    _2
$a HLA antigeny $7 D006680
650    12
$a transplantace srdce $7 D016027
650    _2
$a lidé $7 D006801
650    _2
$a prospektivní studie $7 D011446
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a dárci tkání $7 D014019
650    12
$a optická koherentní tomografie $7 D041623
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Bedanova, Helena $u Cardiovascular and Transplantation Surgery, Brno, Czech Republic
700    1_
$a Chen, Zhi $u Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA, USA
700    1_
$a Kautzner, Josef $u Department of Cardiology, IKEM, Prague, Czech Republic
700    1_
$a Melenovsky, Vojtech $u Department of Cardiology, IKEM, Prague, Czech Republic
700    1_
$a Malek, Ivan $u Department of Cardiology, IKEM, Prague, Czech Republic
700    1_
$a Slavcev, Antonij $u Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Bartonova, Michaela $u Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Karmazin, Vladimir $u Department of Cardiology, IKEM, Prague, Czech Republic
700    1_
$a Eckhardt, Tomas $u Department of Cardiology, IKEM, Prague, Czech Republic
700    1_
$a Tomasek, Ales $u Cardiovascular and Transplantation Surgery, Brno, Czech Republic
700    1_
$a Ozabalova, Eva $u Department of Cardiovascular Diseases, St. Anne's University Hospital and Masaryk University Brno, Czech Republic
700    1_
$a Kovarnik, Tomas $u 2nd Department of Internal Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
700    1_
$a Wohlfahrt, Peter $u Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
700    1_
$a Sonka, Milan $u Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA, USA
773    0_
$w MED00006022 $t Transplant immunology $x 1878-5492 $g Roč. 65, č. - (2021), s. 101340
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33069814 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20220506130246 $b ABA008
999    __
$a ok $b bmc $g 1789907 $s 1163702
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 65 $c - $d 101340 $e 20201015 $i 1878-5492 $m Transplant immunology $n Transpl Immunol $x MED00006022
GRA    __
$a R01 EB004640 $p NIBIB NIH HHS $2 United States
LZP    __
$a Pubmed-20220425

Find record

Citation metrics

Archiving options