• Je něco špatně v tomto záznamu ?

Normalization of Four Different Types of Pulmonary Hypertension After Atrial Septal Defect Closure

J. Rubáčková Popelová, J. Tomek, M. Tomková, R. Živná

. 2022 ; 9 (-) : 876755. [pub] 20220610

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22016986

Pulmonary hypertension (PH) is an established risk factor in patients with atrial septal defect (ASD), and its persistence after ASD closure is associated with increased mortality. Therefore, predictors for PH normalization after defect closure are needed. Multiple hemodynamic types of PH exist, but little is known about their prevalence and prognostic value for PH normalization after ASD closure. We carried out a retrospective study on 97 patients (76% female, median age at ASD closure 58 years) with four types of PH determined predominantly by right heart catheterization: hyperkinetic, pulmonary arterial hypertension, isolated post-capillary, and combined pre- and post-capillary. We investigated the frequency of the PH types and their prognostic significance for PH normalization after ASD closure. Frequency of PH types before ASD closure in our study was: hyperkinetic 55%, pulmonary arterial hypertension 10%, isolated post-capillary PH 24%, and combined PH 11%. Hyperkinetic PH type was positively associated with PH normalization after ASD closure (78% patients normalized), remaining a significant independent predictor when adjusted for age at closure, sex, heart failure, and NYHA. Hyperkinetic PH patients also had significantly better survival prognosis versus patients with other PH types (p = 0.04). Combined PH was negatively associated with PH normalization, with no patients normalizing. Pulmonary arterial hypertension and isolated post-capillary PH had intermediate rates of normalization (60 and 52%, respectively). In summary, all four hemodynamic types of PH are found in adult patients with ASD, and they can be used to stratify patients by their likelihood of PH normalization and survival after ASD closure.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22016986
003      
CZ-PrNML
005      
20220720100046.0
007      
ta
008      
220718s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fcvm.2022.876755 $2 doi
035    __
$a (PubMed)35757340
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Rubáčková Popelová, Jana $u Department of Cardiac Surgery, Na Homolce Hospital, Prague, Czechia $u Pediatric Heart Centre, Motol University Hospital, Prague, Czechia
245    10
$a Normalization of Four Different Types of Pulmonary Hypertension After Atrial Septal Defect Closure / $c J. Rubáčková Popelová, J. Tomek, M. Tomková, R. Živná
520    9_
$a Pulmonary hypertension (PH) is an established risk factor in patients with atrial septal defect (ASD), and its persistence after ASD closure is associated with increased mortality. Therefore, predictors for PH normalization after defect closure are needed. Multiple hemodynamic types of PH exist, but little is known about their prevalence and prognostic value for PH normalization after ASD closure. We carried out a retrospective study on 97 patients (76% female, median age at ASD closure 58 years) with four types of PH determined predominantly by right heart catheterization: hyperkinetic, pulmonary arterial hypertension, isolated post-capillary, and combined pre- and post-capillary. We investigated the frequency of the PH types and their prognostic significance for PH normalization after ASD closure. Frequency of PH types before ASD closure in our study was: hyperkinetic 55%, pulmonary arterial hypertension 10%, isolated post-capillary PH 24%, and combined PH 11%. Hyperkinetic PH type was positively associated with PH normalization after ASD closure (78% patients normalized), remaining a significant independent predictor when adjusted for age at closure, sex, heart failure, and NYHA. Hyperkinetic PH patients also had significantly better survival prognosis versus patients with other PH types (p = 0.04). Combined PH was negatively associated with PH normalization, with no patients normalizing. Pulmonary arterial hypertension and isolated post-capillary PH had intermediate rates of normalization (60 and 52%, respectively). In summary, all four hemodynamic types of PH are found in adult patients with ASD, and they can be used to stratify patients by their likelihood of PH normalization and survival after ASD closure.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Tomek, Jakub $u Department of Cardiac Surgery, Na Homolce Hospital, Prague, Czechia $u Department of Pharmacology, School of Medicine, University of California, Davis, Davis, CA, United States
700    1_
$a Tomková, Markéta $u Department of Cardiac Surgery, Na Homolce Hospital, Prague, Czechia $u Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, United States
700    1_
$a Živná, Renata $u Department of Cardiac Surgery, Na Homolce Hospital, Prague, Czechia
773    0_
$w MED00198704 $t Frontiers in cardiovascular medicine $x 2297-055X $g Roč. 9, č. - (2022), s. 876755
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35757340 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20220718 $b ABA008
991    __
$a 20220720100042 $b ABA008
999    __
$a ind $b bmc $g 1816395 $s 1168228
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 9 $c - $d 876755 $e 20220610 $i 2297-055X $m Frontiers in cardiovascular medicine $n Front Cardiovasc Med $x MED00198704
LZP    __
$a Pubmed-20220718

Najít záznam

Citační ukazatele

Možnosti archivace