Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study

A. Karas, D. Holmannova, P. Borsky, Z. Fiala, C. Andrys, K. Hamakova, T. Svadlakova, V. Palicka, J. Krejsek, V. Rehacek, M. Esterkova, H. Kovarikova, L. Borska

. 2022 ; 10 (5) : . [pub] 20220513

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22017161

Grantová podpora
Progres Q40-09 Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
Progres Q40-10 Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
Progres Q40-11 Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
SVV-260543/2020 Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
Cooperatio Program, research area HEAS Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic

BACKGROUND: This study aims to investigate potential markers of psoriasis and aging, and to elucidate possible connections between these two processes. METHODS: The serum samples of 60 psoriatic patients and 100 controls were analysed, and the levels of four selected parameters (AGEs, RAGE, NAD, and elastin) were determined using commercial ELISA kits. Serum C-reactive protein was assayed using an immune-nephelometry method. FINDINGS: Among the patients, the levels of CRP, AGEs, and RAGE were all increased, while the levels of NAD were reduced when compared to the control group. A negative correlation between the levels of AGEs and NAD was found. A negative correlation between age and the NAD levels among the control group was observed, however among the patients the relationship was diminished. While there was no difference in the levels of native elastin between the patients and the controls, a positive correlation between the levels of native elastin and age and a negative correlation between the levels of native elastin and the severity of psoriasis were found. CONCLUSIONS: The results of our study support the notion of psoriasis and possibly other immune-mediated diseases accelerating the aging process through sustained systemic damage. The serum levels of CRP, NAD, AGEs, and RAGE appear to be promising potential biomarkers of psoriasis. The decrease in the serum levels of NAD is associated with (pro)inflammatory states. Our analysis indicates that the levels of native elastin might strongly reflect both the severity of psoriasis and the aging process.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22017161
003      
CZ-PrNML
005      
20231116133849.0
007      
ta
008      
220718s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/biomedicines10051133 $2 doi
035    __
$a (PubMed)35625870
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Karas, Adam $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $1 https://orcid.org/0000000163520976
245    10
$a Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study / $c A. Karas, D. Holmannova, P. Borsky, Z. Fiala, C. Andrys, K. Hamakova, T. Svadlakova, V. Palicka, J. Krejsek, V. Rehacek, M. Esterkova, H. Kovarikova, L. Borska
520    9_
$a BACKGROUND: This study aims to investigate potential markers of psoriasis and aging, and to elucidate possible connections between these two processes. METHODS: The serum samples of 60 psoriatic patients and 100 controls were analysed, and the levels of four selected parameters (AGEs, RAGE, NAD, and elastin) were determined using commercial ELISA kits. Serum C-reactive protein was assayed using an immune-nephelometry method. FINDINGS: Among the patients, the levels of CRP, AGEs, and RAGE were all increased, while the levels of NAD were reduced when compared to the control group. A negative correlation between the levels of AGEs and NAD was found. A negative correlation between age and the NAD levels among the control group was observed, however among the patients the relationship was diminished. While there was no difference in the levels of native elastin between the patients and the controls, a positive correlation between the levels of native elastin and age and a negative correlation between the levels of native elastin and the severity of psoriasis were found. CONCLUSIONS: The results of our study support the notion of psoriasis and possibly other immune-mediated diseases accelerating the aging process through sustained systemic damage. The serum levels of CRP, NAD, AGEs, and RAGE appear to be promising potential biomarkers of psoriasis. The decrease in the serum levels of NAD is associated with (pro)inflammatory states. Our analysis indicates that the levels of native elastin might strongly reflect both the severity of psoriasis and the aging process.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Holmannova, Drahomira $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $1 https://orcid.org/0000000298659991
700    1_
$a Borsky, Pavel $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $1 https://orcid.org/0000000152532808 $7 xx0268728
700    1_
$a Fiala, Zdenek $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Andrys, Ctirad $u Institute of Clinical Immunology and Allergology, University Hospital, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Hamakova, Kvetoslava $u Clinic of Dermal and Venereal Diseases, University Hospital, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Svadlakova, Tereza $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $u Institute of Clinical Immunology and Allergology, University Hospital, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $1 https://orcid.org/0000000215815531 $7 xx0268729
700    1_
$a Palicka, Vladimir $u Institute of Clinical Biochemistry and Diagnostics, University Hospital, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $1 https://orcid.org/0000000172361647 $7 jn99240000830
700    1_
$a Krejsek, Jan $u Institute of Clinical Immunology and Allergology, University Hospital, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Rehacek, Vit $u Transfusion Center, University Hospital, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Esterková, Monika $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $7 xx0310036
700    1_
$a Kovarikova, Helena $u Institute of Clinical Biochemistry and Diagnostics, University Hospital, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Borska, Lenka $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic $1 https://orcid.org/0000000285801485 $7 nlk20060173900
773    0_
$w MED00205373 $t Biomedicines $x 2227-9059 $g Roč. 10, č. 5 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35625870 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20220718 $b ABA008
991    __
$a 20231116133844 $b ABA008
999    __
$a ind $b bmc $g 1816464 $s 1168403
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 10 $c 5 $e 20220513 $i 2227-9059 $m Biomedicines $n Biomedicines $x MED00205373
GRA    __
$a Progres Q40-09 $p Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
GRA    __
$a Progres Q40-10 $p Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
GRA    __
$a Progres Q40-11 $p Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
GRA    __
$a SVV-260543/2020 $p Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
GRA    __
$a Cooperatio Program, research area HEAS $p Charles University, Faculty of Medicine in Hradec Kralove, the Czech Republic
LZP    __
$a Pubmed-20220718

Najít záznam

Citační ukazatele

Možnosti archivace