-
Je něco špatně v tomto záznamu ?
Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation
DM. Kopustinskiene, R. Masteikova, R. Lazauskas, J. Bernatoniene
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2012-03-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
35453344
DOI
10.3390/antiox11040660
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9-tetrahydrocannabinol (THC) and nonpsychoactive cannabidiol (CBD) are the main pharmacologically active compounds of Cannabis sativa. These compounds have, for a long time, been under extensive investigation, and their potent antioxidant and inflammatory properties have been reported, although the detailed mechanisms of their actions have not been fully clarified. CB1 receptors are suggested to be responsible for the analgesic effect of THC, while CB2 receptors may account for its immunomodulatory properties. Unlike THC, CBD has a very low affinity for both CB1 and CB2 receptors, and behaves as their negative allosteric modulator. CBD activity, as a CB2 receptor inverse agonist, could be important for CBD anti-inflammatory properties. In this review, we discuss the chemical properties and bioavailability of THC and CBD, their main mechanisms of action, and their role in oxidative stress and inflammation.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22017507
- 003
- CZ-PrNML
- 005
- 20220720100245.0
- 007
- ta
- 008
- 220718s2022 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/antiox11040660 $2 doi
- 035 __
- $a (PubMed)35453344
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Kopustinskiene, Dalia M $u Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, 50161 Kaunas, Lithuania $1 https://orcid.org/0000000233992849
- 245 10
- $a Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation / $c DM. Kopustinskiene, R. Masteikova, R. Lazauskas, J. Bernatoniene
- 520 9_
- $a Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9-tetrahydrocannabinol (THC) and nonpsychoactive cannabidiol (CBD) are the main pharmacologically active compounds of Cannabis sativa. These compounds have, for a long time, been under extensive investigation, and their potent antioxidant and inflammatory properties have been reported, although the detailed mechanisms of their actions have not been fully clarified. CB1 receptors are suggested to be responsible for the analgesic effect of THC, while CB2 receptors may account for its immunomodulatory properties. Unlike THC, CBD has a very low affinity for both CB1 and CB2 receptors, and behaves as their negative allosteric modulator. CBD activity, as a CB2 receptor inverse agonist, could be important for CBD anti-inflammatory properties. In this review, we discuss the chemical properties and bioavailability of THC and CBD, their main mechanisms of action, and their role in oxidative stress and inflammation.
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Masteikova, Ruta $u Department of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, 61200 Brno, Czech Republic
- 700 1_
- $a Lazauskas, Robertas $u Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
- 700 1_
- $a Bernatoniene, Jurga $u Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, 50161 Kaunas, Lithuania $u Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, 50161 Kaunas, Lithuania $1 https://orcid.org/0000000317442932
- 773 0_
- $w MED00200130 $t Antioxidants (Basel, Switzerland) $x 2076-3921 $g Roč. 11, č. 4 (2022)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35453344 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20220718 $b ABA008
- 991 __
- $a 20220720100240 $b ABA008
- 999 __
- $a ind $b bmc $g 1816620 $s 1168749
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 11 $c 4 $e 20220329 $i 2076-3921 $m Antioxidants $n Antioxidants $x MED00200130
- LZP __
- $a Pubmed-20220718