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Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study

M. Helan, J. Malaska, J. Tomandl, J. Jarkovsky, K. Helanova, K. Benesova, M. Sitina, M. Dastych, T. Ondrus, M. Pavkova Goldbergova, R. Gal, P. Lokaj, M. Tomandlova, J. Parenica

. 2022 ; 11 (4) : . [pub] 20220326

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22017518

Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the most important mechanisms of shock progression to multiple organ failure. In the present pilot study, we have analysed eight oxidative-stress-related biomarkers in seven consecutive time points (i.e., the first seven days) in 21 septic shock patients admitted to the ICU. Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2'-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin). Furthermore, we analysed each biomarker's ability to predict mortality at the time of admission and 12 h after admission. Although a small number of study subjects were recruited, we have identified four promising molecules for further investigation: soluble endoglin, superoxide dismutase, asymmetric dimethylarginine and neopterin.

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$a Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the most important mechanisms of shock progression to multiple organ failure. In the present pilot study, we have analysed eight oxidative-stress-related biomarkers in seven consecutive time points (i.e., the first seven days) in 21 septic shock patients admitted to the ICU. Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2'-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin). Furthermore, we analysed each biomarker's ability to predict mortality at the time of admission and 12 h after admission. Although a small number of study subjects were recruited, we have identified four promising molecules for further investigation: soluble endoglin, superoxide dismutase, asymmetric dimethylarginine and neopterin.
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$a Tomandl, Josef $u Department of Biochemistry, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
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$a Jarkovsky, Jiri $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
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$a Helanova, Katerina $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $u Department of Internal Medicine and Cardiology, University Hospital Brno, 625 00 Brno, Czech Republic
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$a Benesova, Klara $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
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$a Sitina, Michal $u Department of Anaesthesiology and Intensive Care, St. Anne's University Hospital Brno, 656 91 Brno, Czech Republic $u International Clinical Research Center (ICRC), St. Anne's University Hospital Brno, 656 91 Brno, Czech Republic $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
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$a Dastych, Milan $u Department of Laboratory Methods, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
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$a Parenica, Jiri $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $u Department of Internal Medicine and Cardiology, University Hospital Brno, 625 00 Brno, Czech Republic
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