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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
J. Manry, P. Bastard, A. Gervais, T. Le Voyer, J. Rosain, Q. Philippot, E. Michailidis, HH. Hoffmann, S. Eto, M. Garcia-Prat, L. Bizien, A. Parra-Martínez, R. Yang, L. Haljasmägi, M. Migaud, K. Särekannu, J. Maslovskaja, N. de Prost, Y....
Proceedings of the National Academy of Sciences of the United States of America.
2022 ;
119 (21) :
e2200413119.
[pub] 20220516
Language English Country United States
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Intramural
Persistent link
https://www.medvik.cz/link/bmc22018338
Grant support
R01AI088364
HHS | National Institutes of Health (NIH)
R01AI163029
HHS | National Institutes of Health (NIH)
UL1TR001866
HHS | NIH | National Center for Advancing Translational Sciences (NCATS)
1ZIAAI001265
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)
ZIA AI001270
Intramural NIH HHS - United States
UM1HG006504
HHS | NIH | National Human Genome Research Institute (NHGRI)
U24HG008956
HHS | NIH | National Human Genome Research Institute (NHGRI)
S10OD018521
HHS | NIH | NIH Office of the Director (OD)
P01AI138398-S1
HHS | National Institutes of Health (NIH)
2U19AI111825
HHS | National Institutes of Health (NIH)
R01AI091707-10S1
HHS | National Institutes of Health (NIH)
Online
Full text
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- MeSH
- Autoimmunity * MeSH
- Autoantibodies * blood MeSH
- COVID-19 * immunology mortality MeSH
- Adult MeSH
- Interferon Type I * immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Antibodies, Neutralizing * blood MeSH
- Risk MeSH
- SARS-CoV-2 * MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Age Factors MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
ADMA Biologics Inc Ramsey NJ 07446
Catalan Institution of Research and Advanced Studies 08010 Barcelona Spain
Centre for Biomedical Research on Rare Diseases U759 Instituto de Salud Carlos 3 28029 Madrid Spain
Cerba HealthCare 92130 Issy les Moulineaux France
College of Medicine Imam Abdulrahman Bin Faisal University Dammam 34212 Saudi Arabia
Department of Age Related Healthcare Tallaght University Hospital Dublin D24 NR0A Ireland
Department of Biomedicine Aarhus University 8000 Aarhus Denmark
Department of Biosciences and Nutrition Karolinska Institutet 171 77 Stockholm Sweden
Department of Clinical Immunology Aarhus University Hospital 8000 Aarhus Denmark
Department of Critical Care Medicine Clínica Universidad de La Sabana 250001 Chía Colombia
Department of Genetics Yale University School of Medicine New Haven CT 06520
Department of Human Genomics and Evolution Collège de France 75231 Paris France
Department of Infectious Diseases Aarhus University Hospital 8000 Aarhus Denmark
Department of Internal Medicine 2 Medical University of Innsbruck 6020 Innsbruck Austria
Department of Internal Medicine Infanta Leonor University Hospital 28031 Madrid Spain
Department of Medical Genetics Acibadem University School of Medicine 34750 Istanbul Turkey
Department of Medical Gerontology School of Medicine Trinity College Dublin Dublin D08 W9RT Ireland
Department of Medical Microbiology University Medical Center Utrecht 3584 CX Utrecht The Netherlands
Department of Microbiology Universidad de La Sabana 250001 Chía Colombia
Department of Molecular Biology and Genetics Bilkent University 06800 Ankara Turkey
Department of Neurosurgery Yale University School of Medicine New Haven CT 06510
Department of Paediatrics and Adolescent Medicine University of Hong Kong Hong Kong 999077 China
Department of Pediatrics King Fahad Hospital of the University Al Khobar 34445 Saudi Arabia
Division of Geriatric Medicine Tours University Medical Center 37044 Tours France
Etablissement Français du Sang 93218 La Plaine Saint Denis France
Etablissement Français du Sang Auvergne Rhône Alpes 42000 Saint Étienne France
Faculdades Pequeno Príncipe Instituto de Pesquisa Pelé Pequeno Príncipe 80250 200 Curitiba Brazil
Faculty of Medical Sciences University Goce Delchev Štip 2000 Republic of North Macedonia
Feinstein Institutes for Medical Research Northwell Health Manhasset NY 11030
Fundació Docència i Recerca Mutua Terrassa 08221 Terrassa Spain
Fundación Rioja Salud Centro de Investigación Biomédica de La Rioja 26006 Logroño Spain
Garvan Institute of Medical Research Sydney NWS 2010 Australia
HHMI Rockefeller University New York NY 10065
Hospices Civils de Lyon 69002 Lyon France
Hospital Universitari MútuaTerrassa Universitat de Barcelona 08193 Barcelona Spain
Human Evolutionary Genetics Unit Institut Pasteur CNRS UMR 2000 75015 Paris France
Imagine Institute Université de Paris INSERM UMR 1163 75015 Paris France
Imagine Institute University of Paris 75015 Paris France
Immunology Research Lab College of Medicine King Saud University 11362 Riyadh Saudi Arabia
Immunopathology Federation Lyon Immunopathology Federation Hospices Civils de Lyon 69002 Lyon France
INSERM U1138 Centre de Recherche des Cordeliers 75006 Paris France
INSERM UMRS 1166 iCAN Institute of Cardiometabolism and Nutrition 75013 Paris France
Institut d'Investigacions Biomèdiques August Pi i Sunyer 08036 Barcelona Spain
Institut Necker Enfants Malades INSERM U1151 CNRS UMR 8253 Université de Paris 75015 Paris France
Institute for Biomedical Research Spanish National Research Council 08036 Barcelona Spain
Institute for Health Science Research Germans Trias i Pujol 08916 Badalona Spain
Institute for Systems Biology Seattle WA 98109
Institute of Biomedicine and Translational Medicine University of Tartu 50090 Tartu Estonia
Intensive Care Unit Grand Hôpital de l'Est Francilien Site de Marne La Vallée 77600 Jossigny France
IrsiCaixa AIDS Research Institute 08916 Badalona Spain
Laboratoire d'Immunologie Hospices Civils de Lyon Hôpital Edouard Herriot 69437 Lyon France
Laboratory of Molecular Immunology Rockefeller University New York NY 10065
Laboratory of Virology and Infectious Disease Rockefeller University New York NY 10065
Medical Intensive Care Unit University Hospitals Leuven 3000 Leuven Belgium
Meram Faculty of Medicine Necmettin Erbakan University 42080 Konya Turkey
Neurometabolic Diseases Laboratory The Bellvitge Biomedical Research Institute 08908 Barcelona Spain
Paris Cardiovascular Research Center INSERM Université de Paris 75015 Paris France
Primary Immunodeficiencies Group University of Antioquia UdeA 050010 Medellin Colombia
Sackler Faculty of Medicine Tel Aviv University 6997801 Tel Aviv Israel
School of Life Sciences École Polytechnique Fédérale de Lausanne 1015 Lausanne Switzerland
School of Microbiology University of Antioquia UdeA 050010 Medellin Colombia
Service de Biologie Clinique and UMR S 1176 Hôpital Foch 92150 Suresnes France
Shupyk National Healthcare University of Ukraine 04112 Kyiv Ukraine
Sorbonne Université INSERM Centre d'Immunologie et des Maladies Infectieuses 75013 Paris France
Swiss Institute of Bioinformatics 1015 Lausanne Switzerland
The Genetics Institute and Genomics Center Tel Aviv Sourasky Medical Center 6423906 Tel Aviv Israel
Translational Immunology Unit Institut Pasteur Université Paris Cité 75015 Paris France
Université de Paris Infection Antimicrobials Modelling Evolution UMR 1137 INSERM 75870 Paris France
University of Bordeaux INSERM Bordeaux Population Health Center UMR1219 F 33000 Bordeaux France
University of São Paulo 05508 060 São Paulo Brazil
Yale Center for Genome Analysis Yale School of Medicine New Haven CT 06511
References provided by Crossref.org
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- 700 1_
- $a Mégarbane, Bruno $u Réanimation Médicale et Toxicologique, Hôpital Lariboisière Assistance Publique-Hôpitaux de Paris, Université de Paris, INSERM, UMRS-1144, 75010 Paris, France
- 700 1_
- $a Triantafyllia, Vasiliki $u Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece
- 700 1_
- $a Fekkar, Arnaud $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France $u Service de Parasitologie-Mycologie, Groupe Hospitalier Pitié Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France
- 700 1_
- $a Heath, James R $u Institute for Systems Biology, Seattle, WA 98109
- 700 1_
- $a Franco, José Luis $u Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UdeA, 050010 Medellín, Colombia
- 700 1_
- $a Anaya, Juan-Manuel $u Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 110111 Bogotá, Colombia
- 700 1_
- $a Solé-Violán, Jordi $u Intensive Care Medicine, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, 35010 Las Palmas de Gran Canaria, Spain $u Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain $u Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain
- 700 1_
- $a Imberti, Luisa $u CHemato-oncology Research Laboratory of Associazione italiana contro le leucemie-linfomi e mieloma, Diagnostic Departement, Azienda Socio Sanitaria Territoriale, Spedali Civili di Brescia, 25123 Brescia, Italy
- 700 1_
- $a Biondi, Andrea $u Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN), University of Milano Bicocca, Fondazione Monza Brianza Bambino Mamma (MBBM), Ospedale San Gerardo, 20900 Monza, Italy
- 700 1_
- $a Bonfanti, Paolo $u Department of Infectious Diseases, San Gerardo Hospital, University of Milano Bicocca, 20900 Monza, Italy $1 https://orcid.org/0000000172898823
- 700 1_
- $a Castagnoli, Riccardo $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892 $u Pediatric Clinic, Fondazione Istituto di Ricovero e Cura a carattere scientifico (IRCCS) Policlinico San Matteo, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
- 700 1_
- $a Delmonte, Ottavia M $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892
- 700 1_
- $a Zhang, Yu $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892 $u National Institute of Allergy and Infectious Diseases (NIAID) Clinical Genomics Program, NIH, Bethesda, MD 20892
- 700 1_
- $a Snow, Andrew L $u Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 $1 https://orcid.org/0000000287286691
- 700 1_
- $a Holland, Steven M $u Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892
- 700 1_
- $a Biggs, Catherine M $u Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC V6H 0B3, Canada
- 700 1_
- $a Moncada-Vélez, Marcela $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065
- 700 1_
- $a Arias, Andrés Augusto $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065 $u Primary Immunodeficiencies Group, University of Antioquia UdeA, 050010 Medellin, Colombia $u School of Microbiology, University of Antioquia UdeA, 050010 Medellin, Colombia
- 700 1_
- $a Lorenzo, Lazaro $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France $u Imagine Institute, University of Paris, 75015 Paris, France
- 700 1_
- $a Boucherit, Soraya $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France $u Imagine Institute, University of Paris, 75015 Paris, France
- 700 1_
- $a Anglicheau, Dany $u Department of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France $u Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, Université de Paris, 75015 Paris, France
- 700 1_
- $a Planas, Anna M $u Institute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain $u Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain $1 https://orcid.org/0000000261471880
- 700 1_
- $a Haerynck, Filomeen $u Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, 9000 Ghent, Belgium
- 700 1_
- $a Duvlis, Sotirija $u Faculty of Medical Sciences, University "Goce Delchev," Štip 2000, Republic of North Macedonia $u Institute of Public Health of the Republic of North Macedonia, Skopje 1000, Republic of North Macedonia
- 700 1_
- $a Ozcelik, Tayfun $u Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey
- 700 1_
- $a Keles, Sevgi $u Meram Faculty of Medicine, Necmettin Erbakan University, 42080 Konya, Turkey
- 700 1_
- $a Bousfiha, Ahmed A $u Clinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco $u Laboratoire d'Immunologie Clinique, Inflammation et Allergie (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, 20250 Casablanca, Morocco
- 700 1_
- $a El Bakkouri, Jalila $u Clinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco $u Laboratoire d'Immunologie Clinique, Inflammation et Allergie (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, 20250 Casablanca, Morocco
- 700 1_
- $a Ramirez-Santana, Carolina $u Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 111211 Bogotá, Colombia
- 700 1_
- $a Paul, Stéphane $u Department of Immunology, CIC1408, Groupe sur l'Immunité des Muqueuses et des Agents Pathogènes (GIMAP) Centre International de Recherche en Infectiologie, INSERM U1111, University Hospital of Saint-Étienne, 42000 Saint-Étienne, France $1 https://orcid.org/0000000288304273
- 700 1_
- $a Pan-Hammarström, Qiang $u Department of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden
- 700 1_
- $a Hammarström, Lennart $u Department of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden
- 700 1_
- $a Dupont, Annabelle $u University of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France
- 700 1_
- $a Kurolap, Alina $u The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel
- 700 1_
- $a Metz, Christine N $u Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030
- 700 1_
- $a Aiuti, Alessandro $u Vita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy
- 700 1_
- $a Casari, Giorgio $u Vita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy
- 700 1_
- $a Lampasona, Vito $u Diabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy
- 700 1_
- $a Ciceri, Fabio $u Hematology and Bone Marrow Transplantation Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele University Vita-Salute San Raffaele, 20132 Milano, Italy
- 700 1_
- $a Barreiros, Lucila A $u Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil
- 700 1_
- $a Dominguez-Garrido, Elena $u Fundación Rioja Salud, Centro de Investigación Biomédica de La Rioja, 26006 Logroño, Spain
- 700 1_
- $a Vidigal, Mateus $u University of São Paulo, 05508-060 São Paulo, Brazil
- 700 1_
- $a Zatz, Mayana $u University of São Paulo, 05508-060 São Paulo, Brazil
- 700 1_
- $a van de Beek, Diederik $u Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands
- 700 1_
- $a Sahanic, Sabina $u Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria
- 700 1_
- $a Tancevski, Ivan $u Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria
- 700 1_
- $a Stepanovskyy, Yurii $u Shupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine
- 700 1_
- $a Boyarchuk, Oksana $u Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, 46022 Ternopil, Ukraine
- 700 1_
- $a Nukui, Yoko $u Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo 113-8655, Japan
- 700 1_
- $a Tsumura, Miyuki $u Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan
- 700 1_
- $a Vidaur, Loreto $u Intensive Care Medicine, Donostia University Hospital, Biodonostia Institute of Donostia, 20014 San Sebastián, Spain $u Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain
- 700 1_
- $a Tangye, Stuart G $u Garvan Institute of Medical Research, Sydney, NWS 2010, Australia $u St Vincent's Clinical School, Faculty of Medicine and Health, University of New South Wales, Sydney, NWS 2010, Australia
- 700 1_
- $a Burrel, Sonia $u Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Service de Virologie, 75013 Paris, France
- 700 1_
- $a Duffy, Darragh $u Translational Immunology Unit, Institut Pasteur, Université Paris Cité, 75015 Paris, France $1 https://orcid.org/0000000288752308
- 700 1_
- $a Quintana-Murci, Lluis $u Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015 Paris, France $u Department of Human Genomics and Evolution, Collège de France, 75231 Paris, France
- 700 1_
- $a Klocperk, Adam $u Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, 150 06 Prague, Czech Republic
- 700 1_
- $a Kann, Nelli Y $u Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997
- 700 1_
- $a Shcherbina, Anna $u Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997
- 700 1_
- $a Lau, Yu-Lung $u Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China
- 700 1_
- $a Leung, Daniel $u Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China
- 700 1_
- $a Coulongeat, Matthieu $u Division of Geriatric Medicine, Tours University Medical Center, 37044 Tours, France
- 700 1_
- $a Marlet, Julien $u INSERM U1259, Morphogenèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours, 37044 Tours, France $u Service de Bactériologie, Virologie et Hygiène Hospitalière, Centre Hospitalier Universitaire de Tours, 37044 Tours, France $1 https://orcid.org/0000000286458703
- 700 1_
- $a Koning, Rutger $u Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands
- 700 1_
- $a Reyes, Luis Felipe $u Department of Microbiology, Universidad de La Sabana, 250001 Chía, Colombia $u Department of Critical Care Medicine, Clínica Universidad de La Sabana, 250001 Chía, Colombia
- 700 1_
- $a Chauvineau-Grenier, Angélique $u Service de Biologie Médicale, Centre Hospitalier Intercommunal Robert Ballanger, 93600 Aulnay-sous-Bois, France
- 700 1_
- $a Venet, Fabienne $u Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France $u Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, 69007 Lyon, France $u EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, BioMérieux, Hôpital Edouard Herriot, 69437 Lyon, France $1 https://orcid.org/0000000304624235
- 700 1_
- $a Monneret, Guillaume $u Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France $u EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, BioMérieux, Hôpital Edouard Herriot, 69437 Lyon, France
- 700 1_
- $a Nussenzweig, Michel C $u Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065 $u HHMI, Rockefeller University, New York, NY 10065
- 700 1_
- $a Arrestier, Romain $u Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France $u Groupe de Recherche Clinique Cardiovascular and Respiratory Manifestations of Acute Lung Injury and Sepsis (CARMAS), Faculté de santé de Créteil, Université Paris Est Créteil, 94010 Créteil Cedex, France
- 700 1_
- $a Boudhabhay, Idris $u Department of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France $u Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, Université de Paris, 75015 Paris, France
- 700 1_
- $a Baris-Feldman, Hagit $u The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel $u Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel
- 700 1_
- $a Hagin, David $u Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel $u Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel
- 700 1_
- $a Wauters, Joost $u Medical Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium
- 700 1_
- $a Meyts, Isabelle $u Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, 3000 Leuven, Belgium $u Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, 3000 Leuven, Belgium
- 700 1_
- $a Dyer, Adam H $u Department of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland $u Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland $1 https://orcid.org/000000031356510X
- 700 1_
- $a Kennelly, Sean P $u Department of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland $u Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland
- 700 1_
- $a Bourke, Nollaig M $u Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland
- 700 1_
- $a Halwani, Rabih $u Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates $u Immunology Research Lab, College of Medicine, King Saud University, 11362 Riyadh, Saudi Arabia
- 700 1_
- $a Sharif-Askari, Fatemeh Saheb $u Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates
- 700 1_
- $a Dorgham, Karim $u Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, 75013 Paris, France
- 700 1_
- $a Sallette, Jérôme $u Cerba HealthCare, 92130 Issy-les-Moulineaux, France
- 700 1_
- $a Sedkaoui, Souad Mehlal $u Cerba HealthCare, 92130 Issy-les-Moulineaux, France
- 700 1_
- $a AlKhater, Suzan $u Department of Pediatrics, King Fahad Hospital of the University, Al Khobar 34445, Saudi Arabia $u College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia
- 700 1_
- $a Rigo-Bonnin, Raúl $u Department of Clinical Laboratory, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
- 700 1_
- $a Morandeira, Francisco $u Department of Immunology, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
- 700 1_
- $a Roussel, Lucie $u Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada $u Infectious Disease Susceptibility Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada
- 700 1_
- $a Vinh, Donald C $u Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada $u Infectious Disease Susceptibility Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada
- 700 1_
- $a Erikstrup, Christian $u Department of Clinical Immunology, Aarhus University Hospital, 8000 Aarhus, Denmark
- 700 1_
- $a Condino-Neto, Antonio $u Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil $1 https://orcid.org/0000000210693117
- 700 1_
- $a Prando, Carolina $u Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, 80250-200 Curitiba, Brazil
- 700 1_
- $a Bondarenko, Anastasiia $u Shupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine
- 700 1_
- $a Spaan, András N $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065 $u Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
- 700 1_
- $a Gilardin, Laurent $u Service de Médecine Interne, Hôpital Universitaire Jean-Verdier, Assistance Publique-Hôpitaux de Paris, 93140 Bondy, France $u INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France
- 700 1_
- $a Fellay, Jacques $u School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland $u Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland $u Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland $1 https://orcid.org/000000028240939X
- 700 1_
- $a Lyonnet, Stanislas $u Imagine Institute, Université de Paris, INSERM, UMR 1163, 75015 Paris, France
- 700 1_
- $a Bilguvar, Kaya $u Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06511 $u Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 $u Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510 $u Department of Medical Genetics, Acibadem University School of Medicine, 34750 Istanbul, Turkey
- 700 1_
- $a Lifton, Richard P $u Institute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain $u Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06511 $u Department of Genetics, Yale University School of Medicine, New Haven, CT 06520
- 700 1_
- $a Mane, Shrikant $u Department of Genetics, Yale University School of Medicine, New Haven, CT 06520
- 700 1_
- $a Anderson, Mark S $u Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain
- 700 1_
- $a Boisson, Bertrand $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France $u Imagine Institute, University of Paris, 75015 Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065 $1 https://orcid.org/0000000152403555
- 700 1_
- $a Béziat, Vivien $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France $u Imagine Institute, University of Paris, 75015 Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065 $1 https://orcid.org/000000024020824X
- 700 1_
- $a Zhang, Shen-Ying $u Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France $u Imagine Institute, University of Paris, 75015 Paris, France $u St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065
- 700 1_
- $a Andreakos, Evangelos $u Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece
- 700 1_
- $a Hermine, Olivier $u Imagine Institute, University of Paris, 75015 Paris, France $u Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, 9000 Ghent, Belgium
- 700 1_
- $a Pujol, Aurora $u Neurometabolic Diseases Laboratory, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain $u Centre for Biomedical Research on Rare Diseases (CIBERER) U759, Instituto de Salud Carlos III, 28029 Madrid, Spain $u Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
- 700 1_
- $a Peterson, Pärt $u Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia
- 700 1_
- $a Mogensen, Trine H $u Department of Infectious Diseases, Aarhus University Hospital, 8000 Aarhus, Denmark $u Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
- 700 1_
- $a Rowen, Lee $u Institute for Systems Biology, Seattle, WA 98109
- 700 1_
- $a Mond, James $u ADMA Biologics Inc., Ramsey, NJ 07446
- 700 1_
- $a Debette, Stéphanie $u University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France $u Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, F-33000 Bordeaux, France
- 700 1_
- $a de Lamballerie, Xavier $u Institut Hospitalo-Universitaire Méditerranée Infection, Unité des Virus Émergents, Aix-Marseille University, Institut pour la Recherche et le Développment (IRD) 190, INSERM 1207, 13005 Marseille, France
- 700 1_
- $a Burdet, Charles $u Epidémiologie clinique du Centre d'Investigation Clinique (CIC-EP), INSERM CIC 1425, Hôpital Bichat, 75018 Paris, France $u Université de Paris, Infection Antimicrobials Modelling Evolution (IAME), UMR 1137, INSERM, 75870 Paris, France $u Département Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018 Paris, France
- 700 1_
- $a Bouadma, Lila $u Université de Paris, Infection Antimicrobials Modelling Evolution (IAME), UMR 1137, INSERM, 75870 Paris, France $u Service de Réanimation Médicale et des Maladies Infectieuses, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Nord Université de Paris, F-75018 Paris, France
- 700 1_
- $a Zins, Marie $u Cohorte Constances Groupe Hospitalier Universitaire centre, Assistance Publique-Hôpitaux de Paris, Université de Paris, 94800 Villejuif, France
- 700 1_
- $a Soler-Palacin, Pere $u Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
- 700 1_
- $a Colobran, Roger $u Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
- 700 1_
- $a Gorochov, Guy $u Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, 75013 Paris, France $u Département d'Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpétrière, 75015 Paris, France $1 https://orcid.org/0000000320979677
- 700 1_
- $a Solanich, Xavier $u Department of Internal Medicine, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain $1 https://orcid.org/0000000225722187
- 700 1_
- $a Susen, Sophie $u University of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France
- 700 1_
- $a Martinez-Picado, Javier $u IrsiCaixa AIDS Research Institute, 08916 Badalona, Spain $u Institute for Health Science Research Germans Trias i Pujol (IGTP), 08916 Badalona, Spain $u Department of Infectious Diseases and Immunity, University of Vic-Central University of Catalonia, 08500 Vic, Spain $u Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain $u Consorcio Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain $1 https://orcid.org/0000000249162129
- 700 1_
- $a Raoult, Didier $u Microbes, Evolution, Phylogénie et Infection (MEPHI), Institut Hospitalo-Universitaire Méditerranée Infection, Institut de Recherche pour le Développement, Assistance Publique Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France
- 700 1_
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