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TACSTD2 upregulation is an early reaction to lung infection

S. Lenárt, P. Lenárt, L. Knopfová, H. Kotasová, V. Pelková, V. Sedláková, O. Vacek, J. Pokludová, V. Čan, J. Šmarda, K. Souček, A. Hampl, P. Beneš

. 2022 ; 12 (1) : 9583. [pub] 20220610

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018027

Grantová podpora
21-11585S Grantová Agentura České Republiky
18-00145S Grantová Agentura České Republiky
MUNI/A/1689/2020 Masarykova Univerzita
MUNI/A/1522/2020 Masarykova Univerzita
NV18-07-00073 Ministerstvo Zdravotnictví Ceské Republiky
CZ.02.1.01/0.0/16_019/0000868 European Regional Development Fund

TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs.

Citace poskytuje Crossref.org

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