• Je něco špatně v tomto záznamu ?

Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients

TL. Fuchs, F. Maclean, J. Turchini, AC. Vargas, S. Bhattarai, A. Agaimy, A. Hartmann, CS. Kao, C. Ellis, M. Bonert, X. Leroy, LP. Kunju, L. Schwartz, A. Matsika, SR. Williamson, P. Rao, M. Divatia, R. Guarch, F. Algaba, ML. Balancin, M. Zhou, H....

. 2022 ; 35 (6) : 836-849. [pub] 20211223

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018235

Most succinate dehydrogenase (SDH)-deficient renal cell carcinomas (RCCs) demonstrate stereotypical morphology characterized by bland eosinophilic cells with frequent intracytoplasmic inclusions. However, variant morphologic features have been increasingly recognized. We therefore sought to investigate the incidence and characteristics of SDH-deficient RCC with variant morphologies. We studied a multi-institutional cohort of 62 new SDH-deficient RCCs from 59 patients. The median age at presentation was 39 years (range 19-80), with a slight male predominance (M:F = 1.6:1). A relevant family history was reported in 9 patients (15%). Multifocal or bilateral tumors were identified radiologically in 5 patients (8%). Typical morphology was present at least focally in 59 tumors (95%). Variant morphologies were seen in 13 (21%) and included high-grade nuclear features and various combinations of papillary, solid, and tubular architecture. Necrosis was present in 13 tumors, 7 of which showed variant morphology. All 62 tumors demonstrated loss of SDHB expression by immunohistochemistry. None showed loss of SDHA expression. Germline SDH mutations were reported in all 18 patients for whom the results of testing were known. Among patients for whom follow-up data was available, metastatic disease was reported in 9 cases, 8 of whom had necrosis and/or variant morphology in their primary tumor. Three patients died of disease. In conclusion, variant morphologies and high-grade nuclear features occur in a subset of SDH-deficient RCCs and are associated with more aggressive behavior. We therefore recommend grading all SDH-deficient RCCs and emphasize the need for a low threshold for performing SDHB immunohistochemistry in any difficult to classify renal tumor, particularly if occurring at a younger age.

Anatomical Pathology Douglass Hanly Moir Pathology Sonic Healthcare Macquarie Park NSW Australia

Aquesta Pathology Toowong QLD Australia

Brigham and Women's Hospital and Harvard Medical School Boston MA USA

Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research St Leonards NSW Australia

Complejo Hospitalario de Navarra Navarra Spain

Department of Pathology and Laboratory Medicine University of Calgary and Alberta Precision Labs Calgary AB Canada

Department of Pathology and Molecular Pathology University Hospital Zurich and University Zurich Zurich Switzerland

Discipline of Pathology Macquarie Medical School Macquarie University Macquarie Park NSW Australia

Fundació Puigvert Universitat Autonoma de Barcelona Barcelona Spain

Houston Methodist Hospital Houston TX USA

Institut de Pathologie Centre de Biologie Pathologie CHRU Lille France

Institute of Pathology Rede D'OR São Luiz and D'Or Institute for Research and Education São Paulo Brazil

Institute of Pathology University Hospital Erlangen Friedrich Alexander University Erlangen Nürnberg Erlangen Germany

Lab Plus Auckland DHB Auckland New Zealand

Leeds Teaching Hospital Leeds UK

Mater Health Brisbane QLD Australia

McGill University Montreal Canada

McMaster University Hamilton Ontario Canada

Medical Faculty and University Hospital Plzen Charles University Prague Plzen Czech Republic

NHLS Bloemfontein Area Bloemfontein South Africa

NHS Lothian Edinburgh Scotland UK

Northwestern University Chicago IL USA

NSW Health Pathology Department of Anatomical Pathology Royal North Shore Hospital NSW Health Pathology St Leonards NSW Australia

Oncocentro Foundation Sao Paulo Brazil

PathCare Mediclinic Bloemfontein Hospital Bloemfontein South Africa

Peking University Shenzhen Hospital Shenzhen China

Queen Elizabeth Hospital Kowloon Hong Kong SAR China

Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic Cleveland Ohio OH USA

St Teresa's Hospital Kowloon Hong Kong SAR China

Stanford University Medical Center Stanford CA USA

Sunshine Coast University Hospital Pathology Queensland Birtinya QLD Australia

Sydney Medical School The University of Sydney Sydney Australia

The University of Texas MD Anderson Cancer Center Houston TX USA

TissuPath Pathology Melbourne VIC Australia

Tufts Medical Center Boston MA USA

University of California San Francisco San Francisco CA USA

University of Michigan Ann Arbor MI USA

University of Pennsylvania Philadelphia PA USA

University of Queensland Brisbane QLD Australia

University of Southern California Los Angeles CA USA

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22018235
003      
CZ-PrNML
005      
20220804134638.0
007      
ta
008      
220720s2022 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41379-021-00998-1 $2 doi
035    __
$a (PubMed)34949766
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Fuchs, Talia L $u Sydney Medical School, The University of Sydney, Sydney, Australia $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia $u NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, NSW Health Pathology, St Leonards, NSW, Australia $1 https://orcid.org/0000000291666822
245    10
$a Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients / $c TL. Fuchs, F. Maclean, J. Turchini, AC. Vargas, S. Bhattarai, A. Agaimy, A. Hartmann, CS. Kao, C. Ellis, M. Bonert, X. Leroy, LP. Kunju, L. Schwartz, A. Matsika, SR. Williamson, P. Rao, M. Divatia, R. Guarch, F. Algaba, ML. Balancin, M. Zhou, H. Samaratunga, IW. da Cunha, F. Brimo, A. Ryan, D. Clouston, M. Aron, M. O'Donnell, E. Chan, MS. Hirsch, H. Moch, CY. Pang, C. Wah, W. Yin, J. Perry-Keene, A. Yilmaz, A. Chou, A. Clarkson, G. van der Westhuizen, E. Morrison, J. Zwi, O. Hes, K. Trpkov, AJ. Gill
520    9_
$a Most succinate dehydrogenase (SDH)-deficient renal cell carcinomas (RCCs) demonstrate stereotypical morphology characterized by bland eosinophilic cells with frequent intracytoplasmic inclusions. However, variant morphologic features have been increasingly recognized. We therefore sought to investigate the incidence and characteristics of SDH-deficient RCC with variant morphologies. We studied a multi-institutional cohort of 62 new SDH-deficient RCCs from 59 patients. The median age at presentation was 39 years (range 19-80), with a slight male predominance (M:F = 1.6:1). A relevant family history was reported in 9 patients (15%). Multifocal or bilateral tumors were identified radiologically in 5 patients (8%). Typical morphology was present at least focally in 59 tumors (95%). Variant morphologies were seen in 13 (21%) and included high-grade nuclear features and various combinations of papillary, solid, and tubular architecture. Necrosis was present in 13 tumors, 7 of which showed variant morphology. All 62 tumors demonstrated loss of SDHB expression by immunohistochemistry. None showed loss of SDHA expression. Germline SDH mutations were reported in all 18 patients for whom the results of testing were known. Among patients for whom follow-up data was available, metastatic disease was reported in 9 cases, 8 of whom had necrosis and/or variant morphology in their primary tumor. Three patients died of disease. In conclusion, variant morphologies and high-grade nuclear features occur in a subset of SDH-deficient RCCs and are associated with more aggressive behavior. We therefore recommend grading all SDH-deficient RCCs and emphasize the need for a low threshold for performing SDHB immunohistochemistry in any difficult to classify renal tumor, particularly if occurring at a younger age.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    12
$a karcinom z renálních buněk $x genetika $x patologie $7 D002292
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a hyperplazie $7 D006965
650    _2
$a imunohistochemie $7 D007150
650    12
$a nádory ledvin $x genetika $x patologie $7 D007680
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nekróza $7 D009336
650    _2
$a sukcinátdehydrogenasa $x genetika $7 D013385
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Maclean, Fiona $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia $u Anatomical Pathology, Douglass Hanly Moir Pathology, Sonic Healthcare, Macquarie Park, NSW, Australia $u Discipline of Pathology, Macquarie Medical School, Macquarie University, Macquarie Park, NSW, Australia
700    1_
$a Turchini, John $u Sydney Medical School, The University of Sydney, Sydney, Australia $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia $u Anatomical Pathology, Douglass Hanly Moir Pathology, Sonic Healthcare, Macquarie Park, NSW, Australia $u Discipline of Pathology, Macquarie Medical School, Macquarie University, Macquarie Park, NSW, Australia
700    1_
$a Vargas, A Cristina $u Sydney Medical School, The University of Sydney, Sydney, Australia $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia $u Anatomical Pathology, Douglass Hanly Moir Pathology, Sonic Healthcare, Macquarie Park, NSW, Australia $u Discipline of Pathology, Macquarie Medical School, Macquarie University, Macquarie Park, NSW, Australia $1 https://orcid.org/0000000337985088
700    1_
$a Bhattarai, Selina $u Leeds Teaching Hospital, Leeds, UK
700    1_
$a Agaimy, Abbas $u Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany $1 https://orcid.org/0000000204458161
700    1_
$a Hartmann, Arndt $u Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
700    1_
$a Kao, Chia-Sui $u Stanford University Medical Center, Stanford, CA, USA
700    1_
$a Ellis, Carla $u Northwestern University, Chicago, IL, USA
700    1_
$a Bonert, Michael $u McMaster University, Hamilton, Ontario, Canada
700    1_
$a Leroy, Xavier $u Institut de Pathologie, Centre de Biologie-Pathologie, CHRU, Lille, France
700    1_
$a Kunju, Lakshmi P $u University of Michigan, Ann Arbor, MI, USA
700    1_
$a Schwartz, Lauren $u University of Pennsylvania, Philadelphia, PA, USA
700    1_
$a Matsika, Admire $u Mater Health, Brisbane, QLD, Australia $u University of Queensland, Brisbane, QLD, Australia
700    1_
$a Williamson, Sean R $u Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Cleveland, Ohio, OH, USA $1 https://orcid.org/0000000238981460
700    1_
$a Rao, Priya $u The University of Texas MD Anderson Cancer Center, Houston, TX, USA
700    1_
$a Divatia, Mukul $u Houston Methodist Hospital, Houston, TX, USA
700    1_
$a Guarch, Rosa $u Complejo Hospitalario de Navarra, Navarra, Spain
700    1_
$a Algaba, Ferran $u Fundació Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain
700    1_
$a Balancin, Marcelo L $u Oncocentro Foundation, Sao Paulo, Brazil
700    1_
$a Zhou, Ming $u Tufts Medical Center, Boston, MA, USA
700    1_
$a Samaratunga, Hemamali $u University of Queensland, Brisbane, QLD, Australia $u Aquesta Pathology, Toowong, QLD, Australia
700    1_
$a da Cunha, Isabela Werneck $u Institute of Pathology, Rede D'OR-São Luiz and D'Or Institute for Research and Education (IDOR), São Paulo, Brazil $1 https://orcid.org/0000000220295139
700    1_
$a Brimo, Fadi $u McGill University, Montreal, Canada
700    1_
$a Ryan, Andrew $u TissuPath Pathology, Melbourne, VIC, Australia
700    1_
$a Clouston, David $u TissuPath Pathology, Melbourne, VIC, Australia
700    1_
$a Aron, Manju $u University of Southern California, Los Angeles, CA, USA
700    1_
$a O'Donnell, Marie $u NHS Lothian, Edinburgh, Scotland, UK
700    1_
$a Chan, Emily $u University of California San Francisco, San Francisco, CA, USA $1 https://orcid.org/0000000272904004
700    1_
$a Hirsch, Michelle S $u Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA $1 https://orcid.org/0000000287678564
700    1_
$a Moch, Holger $u Department of Pathology and Molecular Pathology, University Hospital Zurich and University Zurich, Zurich, Switzerland $1 https://orcid.org/0000000279862839
700    1_
$a Pang, Chun-Yin $u St. Teresa's Hospital, Kowloon, Hong Kong, SAR, China
700    1_
$a Wah, Cheuk $u Queen Elizabeth Hospital, Kowloon, Hong Kong, SAR, China
700    1_
$a Yin, Weihua $u Peking University Shenzhen Hospital, Shenzhen, China
700    1_
$a Perry-Keene, Joanna $u Aquesta Pathology, Toowong, QLD, Australia $u Sunshine Coast University Hospital, Pathology Queensland, Birtinya, QLD, Australia
700    1_
$a Yilmaz, Asli $u Department of Pathology and Laboratory Medicine, University of Calgary and Alberta Precision Labs, Calgary, AB, Canada
700    1_
$a Chou, Angela $u Sydney Medical School, The University of Sydney, Sydney, Australia $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia $u NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, NSW Health Pathology, St Leonards, NSW, Australia
700    1_
$a Clarkson, Adele $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia $u NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, NSW Health Pathology, St Leonards, NSW, Australia
700    1_
$a van der Westhuizen, Gerhard $u PathCare, Mediclinic Bloemfontein Hospital, Bloemfontein, South Africa
700    1_
$a Morrison, Ella $u NHLS, Bloemfontein Area, Bloemfontein, South Africa
700    1_
$a Zwi, Jonathan $u Lab Plus, Auckland DHB, Auckland, New Zealand
700    1_
$a Hes, Ondrej $u Medical Faculty and University Hospital Plzen, Charles University, Prague, Plzen, Czech Republic
700    1_
$a Trpkov, Kiril $u Department of Pathology and Laboratory Medicine, University of Calgary and Alberta Precision Labs, Calgary, AB, Canada $1 https://orcid.org/0000000331428846
700    1_
$a Gill, Anthony J $u Sydney Medical School, The University of Sydney, Sydney, Australia. a.gill@sydney.edu.au $u Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia. a.gill@sydney.edu.au $u NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, NSW Health Pathology, St Leonards, NSW, Australia. a.gill@sydney.edu.au $1 https://orcid.org/0000000294471967
773    0_
$w MED00003380 $t Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc $x 1530-0285 $g Roč. 35, č. 6 (2022), s. 836-849
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34949766 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804134631 $b ABA008
999    __
$a ok $b bmc $g 1822031 $s 1169478
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 35 $c 6 $d 836-849 $e 20211223 $i 1530-0285 $m Modern pathology $n Mod Pathol $x MED00003380
LZP    __
$a Pubmed-20220720

Najít záznam

Citační ukazatele

Možnosti archivace