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Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor
M. Silverå Ejneby, M. Jakešová, JJ. Ferrero, L. Migliaccio, I. Sahalianov, Z. Zhao, M. Berggren, D. Khodagholy, V. Đerek, JN. Gelinas, ED. Głowacki
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
UIP-2019-04-1753
Hrvatska Zaklada za Znanost (Croatian Science Foundation)
949191
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
2018-04505
Vetenskapsrådet (Swedish Research Council)
KAW-WCMM-LiU
Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)
- MeSH
- elektrická stimulace MeSH
- krysa rodu rattus MeSH
- nervus ischiadicus * fyziologie MeSH
- protézy a implantáty * MeSH
- reprodukovatelnost výsledků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm3 thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-μs pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves.
Central European Institute of Technology Brno University of Technology Brno Czech Republic
Department of Electrical Engineering Columbia University New York NY USA
Department of Neurology Columbia University Medical Center New York NY USA
Department of Physics Faculty of Science University of Zagreb Zagreb Croatia
Institute for Genomic Medicine Columbia University Medical Center New York NY USA
Laboratory of Organic Electronics Campus Norrköping Linköping University Norrköping Sweden
Wallenberg Centre for Molecular Medicine Linköping University Linköping Sweden
Citace poskytuje Crossref.org
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- $a Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm3 thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-μs pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves.
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