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In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231

L. Hunakova, E. Horvathova, M. Matuskova, P. Bobal, J. Otevrel, J. Brtko

. 2022 ; 39 (5) : 99. [pub] 20220523

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018342

Grantová podpora
APVV-15-0372 Agentúra na Podporu Výskumu a Vývoja
APVV-20-0314 Agentúra na Podporu Výskumu a Vývoja
VEGA 2/0126/19 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
VEGA 1/0460/21 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
VEGA 1/0136/18 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
VEGA 1/0489/20 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
VEGA 2/0116/21 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
MUNI/A/1682/2020 Masarykova Univerzita
TRANSMED 2, ITMS: 26240120030 ERDF
TRANSMED, ITMS: 26240120008 ERDF
ITMS: 26240220071 ERDF

E-zdroje Online Plný text

NLK ProQuest Central od 1997-03-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2013-03-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1997-03-01 do Před 1 rokem

Odkazy

PubMed 35599282
DOI 10.1007/s12032-022-01692-1
Knihovny.cz E-zdroje

Intensive investigation for novel antiproliferative and cytotoxic effective chemical compounds is currently concentrated on structurally modified agents of natural or synthetic source. The selenium derivative of triorganotin compound, triphenyltin isoselenocyanate (TPT-NCSe) caused higher cytotoxicity in hormone sensitive MCF 7 (IC 50-250 nM) in comparison with triple-negative MDA-MB-231 breast carcinoma cell line (IC 50-450 nM) as determined by MTT assay. Measurement of DNA damage showed presence of crosslinks in both cell lines treated by increasing TPT-NCSe concentrations. This compound decreased mitochondrial membrane potential shown by JC-1 staining in a concentration-dependent manner in both cell lines. Activation of caspases-3/7 was observed in MDA-MB-231 cells and was significant only by concentrations causing significant level of crosslinks. On the other hand, migration assay revealed inhibitory effect of viability keeping 100 nM concentration of TPT-NCSe on migration of MDA-MB-231 cells. Our data has shown that this selenium containing triorganotin molecule exerts DNA damage-linked antineoplastic activity in breast carcinoma cell lines studied.

Citace poskytuje Crossref.org

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