-
Something wrong with this record ?
Unexplained post-acute infection syndromes
J. Choutka, V. Jansari, M. Hornig, A. Iwasaki
Language English Country United States
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
Grant support
Howard Hughes Medical Institute - United States
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- COVID-19 * complications MeSH
- Humans MeSH
- Disease Progression MeSH
- SARS-CoV-2 MeSH
- Fatigue Syndrome, Chronic * diagnosis etiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an unexplained chronic disability in a minority of patients. These post-acute infection syndromes (PAISs) represent a substantial healthcare burden, but there is a lack of understanding of the underlying mechanisms, representing a significant blind spot in the field of medicine. The relatively similar symptom profiles of individual PAISs, irrespective of the infectious agent, as well as the overlap of clinical features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggest the potential involvement of a common etiopathogenesis. In this Review, we summarize what is known about unexplained PAISs, provide context for post-acute sequelae of SARS-CoV-2 infection (PASC), and delineate the need for basic biomedical research into the underlying mechanisms behind this group of enigmatic chronic illnesses.
Department of Epidemiology Columbia University Mailman School of Public Health New York NY USA
Department of Epidemiology of Microbial Diseases Yale School of Public Health New Haven CT USA
Department of Immunobiology Yale University School of Medicine New Haven CT USA
Department of Molecular Cellular and Developmental Biology Yale University New Haven CT USA
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22018641
- 003
- CZ-PrNML
- 005
- 20220804134927.0
- 007
- ta
- 008
- 220720s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41591-022-01810-6 $2 doi
- 035 __
- $a (PubMed)35585196
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Choutka, Jan $u Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague, Czech Republic. choutka.jan@gmail.com $1 https://orcid.org/0000000162909787
- 245 10
- $a Unexplained post-acute infection syndromes / $c J. Choutka, V. Jansari, M. Hornig, A. Iwasaki
- 520 9_
- $a SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an unexplained chronic disability in a minority of patients. These post-acute infection syndromes (PAISs) represent a substantial healthcare burden, but there is a lack of understanding of the underlying mechanisms, representing a significant blind spot in the field of medicine. The relatively similar symptom profiles of individual PAISs, irrespective of the infectious agent, as well as the overlap of clinical features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggest the potential involvement of a common etiopathogenesis. In this Review, we summarize what is known about unexplained PAISs, provide context for post-acute sequelae of SARS-CoV-2 infection (PASC), and delineate the need for basic biomedical research into the underlying mechanisms behind this group of enigmatic chronic illnesses.
- 650 12
- $a COVID-19 $x komplikace $7 D000086382
- 650 _2
- $a progrese nemoci $7 D018450
- 650 12
- $a syndrom chronické únavy $x diagnóza $x etiologie $7 D015673
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a SARS-CoV-2 $7 D000086402
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Jansari, Viraj $u Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
- 700 1_
- $a Hornig, Mady $u Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA $1 https://orcid.org/0000000175723092
- 700 1_
- $a Iwasaki, Akiko $u Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu $u Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. akiko.iwasaki@yale.edu $u Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA. akiko.iwasaki@yale.edu $u Howard Hughes Medical Institute, Chevy Chase, MD, USA. akiko.iwasaki@yale.edu $1 https://orcid.org/0000000278249856
- 773 0_
- $w MED00003459 $t Nature medicine $x 1546-170X $g Roč. 28, č. 5 (2022), s. 911-923
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35585196 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220720 $b ABA008
- 991 __
- $a 20220804134921 $b ABA008
- 999 __
- $a ok $b bmc $g 1822315 $s 1169884
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 28 $c 5 $d 911-923 $e 20220518 $i 1546-170X $m Nature medicine $n Nat Med $x MED00003459
- GRA __
- $p Howard Hughes Medical Institute $2 United States
- LZP __
- $a Pubmed-20220720
