• Something wrong with this record ?

Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

N. Kudlova, JB. De Sanctis, M. Hajduch

. 2022 ; 23 (8) : . [pub] 20220410

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc22018822

Grant support
LM2018133 Ministry of School, Education, Youth and Sports of the Czech Republic
CZ.02.1.01/0.0/0.0/16_019/0000868 Ministry of School, Education, Youth and Sports of the Czech Republic
TE02000058 Technological agency of the Czech Republic
IGA_LF_2021_036 Palacky University in Olomouc

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. It has many endogenous and exogenous inducers, and is closely connected with age, age-related pathologies, DNA damage, degenerative disorders, tumor suppression and activation, wound healing, and tissue repair. However, the literature is replete with contradictory findings concerning its triggering mechanisms, specific biomarkers, and detection protocols. This may be partly due to the wide range of cellular and in vivo animal or human models of accelerated aging that have been used to study senescence and test senolytic drugs. This review summarizes recent findings concerning senescence, presents some widely used cellular and animal senescence models, and briefly describes the best-known senolytic agents.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22018822
003      
CZ-PrNML
005      
20220804135123.0
007      
ta
008      
220720s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms23084168 $2 doi
035    __
$a (PubMed)35456986
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Kudlova, Natalie $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 77147 Olomouc, Czech Republic $1 https://orcid.org/0000000285109878
245    10
$a Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs / $c N. Kudlova, JB. De Sanctis, M. Hajduch
520    9_
$a Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. It has many endogenous and exogenous inducers, and is closely connected with age, age-related pathologies, DNA damage, degenerative disorders, tumor suppression and activation, wound healing, and tissue repair. However, the literature is replete with contradictory findings concerning its triggering mechanisms, specific biomarkers, and detection protocols. This may be partly due to the wide range of cellular and in vivo animal or human models of accelerated aging that have been used to study senescence and test senolytic drugs. This review summarizes recent findings concerning senescence, presents some widely used cellular and animal senescence models, and briefly describes the best-known senolytic agents.
650    12
$a stárnutí $x genetika $7 D000375
650    _2
$a zvířata $7 D000818
650    _2
$a biologické markery $7 D015415
650    _2
$a kontrolní body buněčného cyklu $7 D059447
650    12
$a stárnutí buněk $x genetika $7 D016922
650    _2
$a poškození DNA $7 D004249
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a De Sanctis, Juan Bautista $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 77147 Olomouc, Czech Republic $u Institute of Molecular and Translational Medicine Czech Advanced Technologies and Research Institute, Palacky University, 77147 Olomouc, Czech Republic
700    1_
$a Hajduch, Marian $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 77147 Olomouc, Czech Republic $u Institute of Molecular and Translational Medicine Czech Advanced Technologies and Research Institute, Palacky University, 77147 Olomouc, Czech Republic $1 https://orcid.org/000000024834908X $7 xx0050218
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 23, č. 8 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35456986 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804135117 $b ABA008
999    __
$a ok $b bmc $g 1822427 $s 1170065
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 23 $c 8 $e 20220410 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a LM2018133 $p Ministry of School, Education, Youth and Sports of the Czech Republic
GRA    __
$a CZ.02.1.01/0.0/0.0/16_019/0000868 $p Ministry of School, Education, Youth and Sports of the Czech Republic
GRA    __
$a TE02000058 $p Technological agency of the Czech Republic
GRA    __
$a IGA_LF_2021_036 $p Palacky University in Olomouc
LZP    __
$a Pubmed-20220720

Find record

Citation metrics

Archiving options