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The role of the electrocardiographic phenotype in risk stratification for sudden cardiac death in childhood hypertrophic cardiomyopathy
G. Norrish, C. Topriceanu, C. Qu, E. Field, H. Walsh, L. Ziółkowska, I. Olivotto, S. Passantino, S. Favilli, A. Anastasakis, V. Vlagkouli, R. Weintraub, I. King, E. Biagini, L. Ragni, T. Prendiville, S. Duignan, K. McLeod, M. Ilina, A. Fernández,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
FS/16/72/32270
British Heart Foundation - United Kingdom
MR/T024062/1
Medical Research Council - United Kingdom
Department of Health - United Kingdom
PubMed
33772274
DOI
10.1093/eurjpc/zwab046
Knihovny.cz E-zdroje
- MeSH
- elektrokardiografie metody MeSH
- fenotyp MeSH
- hodnocení rizik MeSH
- hypertrofická kardiomyopatie * komplikace diagnóza MeSH
- lidé MeSH
- náhlá srdeční smrt * epidemiologie etiologie MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
AIMS: The 12-lead electrocardiogram (ECG) is routinely performed in children with hypertrophic cardiomyopathy (HCM). An ECG risk score has been suggested as a useful tool for risk stratification, but this has not been independently validated. This aim of this study was to describe the ECG phenotype of childhood HCM in a large, international, multi-centre cohort and investigate its role in risk prediction for arrhythmic events. METHODS AND RESULTS: Data from 356 childhood HCM patients with a mean age of 10.1 years (±4.5) were collected from a retrospective, multi-centre international cohort. Three hundred and forty-seven (97.5%) patients had ECG abnormalities at baseline, most commonly repolarization abnormalities (n = 277, 77.8%); left ventricular hypertrophy (n = 240, 67.7%); abnormal QRS axis (n = 126, 35.4%); or QT prolongation (n = 131, 36.8%). Over a median follow-up of 3.9 years (interquartile range 2.0-7.7), 25 (7%) had an arrhythmic event, with an overall annual event rate of 1.38 (95% CI 0.93-2.04). No ECG variables were associated with 5-year arrhythmic event on univariable or multivariable analysis. The ECG risk score threshold of >5 had modest discriminatory ability [C-index 0.60 (95% CI 0.484-0.715)], with corresponding negative and positive predictive values of 96.7% and 6.7. CONCLUSION: In a large, international, multi-centre cohort of childhood HCM, ECG abnormalities were common and varied. No ECG characteristic, either in isolation or combined in the previously described ECG risk score, was associated with 5-year sudden cardiac death risk. This suggests that the role of baseline ECG phenotype in improving risk stratification in childhood HCM is limited.
Alder Hey Children's hospital Liverpool UK
Bambino Gesu Hospital Rome Italy
Cardiology Unit A Meyer Pediatric Hospital Florence Italy
Careggi University Hospital Florence Italy
Complexo Hospitalario Universitario A Coruña CIBERCV A Coruña Spain
Department of cardiology Aarhus University Hospital Aarhus Denmark
Department of Cardiology and Geriatrics Kochi Medical School Kochi University Japan
Department of Cardiology The Children's Memorial Health Institute Warsaw Poland
Department of Statistical Science University College London London UK
Favaloro Foundation University Hospital Buenos Aires Argentina
Hospital General Universitario Gregorio Marañón Madrid Spain
Hospital Universitario Puerta de Hierro Majadahonda CIBERCV Madrid Spain
Institute of Cardiovascular Sciences University College London London UK
John Radcliffe Hospital Oxford UK
Leiden University Medical Center Leiden Netherlands
Medical Sciences Department School of Medicine University of Girona
Odense University Hospital Odense Denmark
Onassis Cardiac Surgery Center Athens Greece
Our Lady's Children's Hospital Dublin Ireland
Papa Giovanni XXIII hospital Bergamo Italy
Royal Brompton and Harefield NHS Trust London UK
Royal Hospital for Children Glasgow UK
S Orsola Malpighi Hospital Bologna Italy
Southampton general Hospital Southampton UK
The Freeman Hospital Newcastle UK
The Murdoch Children's Research Institute
The Royal Children's Hospital Melbourne Australia
University Francisco de Vitoria Pozuelo de Alarcon Spain
University Hospital Motol Prague Czech Republic
University Hospital of Wales Cardiff UK
University Hospital Virgen de la Arrixaca Murcia Spain
Citace poskytuje Crossref.org
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