-
Je něco špatně v tomto záznamu ?
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
G. Günes Günsel, TM. Conlon, A. Jeridi, R. Kim, Z. Ertüz, NJ. Lang, M. Ansari, M. Novikova, D. Jiang, M. Strunz, M. Gaianova, C. Hollauer, C. Gabriel, I. Angelidis, S. Doll, JC. Pestoni, SL. Edelmann, MS. Kohlhepp, A. Guillot, K. Bassler, HP. Van...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- arginin metabolismus MeSH
- chronická obstrukční plicní nemoc * genetika MeSH
- histony metabolismus MeSH
- intracelulární signální peptidy a proteiny MeSH
- lidé MeSH
- monocyty metabolismus MeSH
- myši MeSH
- proteinarginin-N-methyltransferasy * metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic factor that has the capacity to mono-methylate histones on arginine residues. Here we show that in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression is elevated in the lung tissue and localized to the macrophages. In mouse models of COPD, lung fibrosis and skin injury, reduced expression of PRMT7 associates with decreased recruitment of monocytes to the site of injury and hence less severe symptoms. Mechanistically, activation of NF-κB/RelA in monocytes induces PRMT7 transcription and consequential mono-methylation of histones at the regulatory elements of RAP1A, which leads to increased transcription of this gene that is responsible for adhesion and migration of monocytes. Persistent monocyte-derived macrophage accumulation leads to ALOX5 over-expression and accumulation of its metabolite LTB4, which triggers expression of ACSL4 a ferroptosis promoting gene in lung epithelial cells. Conclusively, inhibition of arginine mono-methylation might offer targeted intervention in monocyte-driven inflammatory conditions that lead to extensive tissue damage if left untreated.
Antwerp Surgical Training Anatomy and Research Centre University of Antwerp 2650 Edegem Belgium
Department for Genomics and Immunoregulation LIMES Institute University of Bonn 53115 Bonn Germany
Division of Pneumology KU Leuven 3000 Leuven Belgium
Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Denver CO 80045 USA
imed analytics 53121 Bonn Germany
Institute of Computational Biology Helmholtz Munich 85764 Munich Germany
Institute of Functional Epigenetics Helmholtz Munich 85764 Munich Germany
Institute of Lung Health and Immunity 85764 Munich Germany
Institute of Metabolism and Cell Death Helmholtz Munich 85764 Munich Germany
Koç University Research Center for Translational Medicine 34010 Istanbul Turkey
Max Delbrück Center for Molecular Medicine 13125 Berlin Germany
Proteomics of cellular signalling Luxembourg Institute of Health 1272 Strassen Luxembourg
Research Unit Molecular Immune Regulation Helmholtz Munich 81377 Munich Germany
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22019191
- 003
- CZ-PrNML
- 005
- 20220804135424.0
- 007
- ta
- 008
- 220720s2022 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41467-022-28809-4 $2 doi
- 035 __
- $a (PubMed)35288557
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Günes Günsel, Gizem $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 245 14
- $a The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD / $c G. Günes Günsel, TM. Conlon, A. Jeridi, R. Kim, Z. Ertüz, NJ. Lang, M. Ansari, M. Novikova, D. Jiang, M. Strunz, M. Gaianova, C. Hollauer, C. Gabriel, I. Angelidis, S. Doll, JC. Pestoni, SL. Edelmann, MS. Kohlhepp, A. Guillot, K. Bassler, HP. Van Eeckhoutte, Ö. Kayalar, N. Konyalilar, T. Kanashova, S. Rodius, C. Ballester-López, CM. Genes Robles, N. Smirnova, M. Rehberg, C. Agarwal, I. Krikki, B. Piavaux, SE. Verleden, B. Vanaudenaerde, M. Königshoff, G. Dittmar, KR. Bracke, JL. Schultze, H. Watz, O. Eickelberg, T. Stoeger, G. Burgstaller, F. Tacke, V. Heissmeyer, Y. Rinkevich, H. Bayram, HB. Schiller, M. Conrad, R. Schneider, AÖ. Yildirim
- 520 9_
- $a Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic factor that has the capacity to mono-methylate histones on arginine residues. Here we show that in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression is elevated in the lung tissue and localized to the macrophages. In mouse models of COPD, lung fibrosis and skin injury, reduced expression of PRMT7 associates with decreased recruitment of monocytes to the site of injury and hence less severe symptoms. Mechanistically, activation of NF-κB/RelA in monocytes induces PRMT7 transcription and consequential mono-methylation of histones at the regulatory elements of RAP1A, which leads to increased transcription of this gene that is responsible for adhesion and migration of monocytes. Persistent monocyte-derived macrophage accumulation leads to ALOX5 over-expression and accumulation of its metabolite LTB4, which triggers expression of ACSL4 a ferroptosis promoting gene in lung epithelial cells. Conclusively, inhibition of arginine mono-methylation might offer targeted intervention in monocyte-driven inflammatory conditions that lead to extensive tissue damage if left untreated.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a arginin $x metabolismus $7 D001120
- 650 _2
- $a histony $x metabolismus $7 D006657
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a intracelulární signální peptidy a proteiny $7 D047908
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a monocyty $x metabolismus $7 D009000
- 650 12
- $a proteinarginin-N-methyltransferasy $x metabolismus $7 D011484
- 650 12
- $a chronická obstrukční plicní nemoc $x genetika $7 D029424
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Conlon, Thomas M $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $1 https://orcid.org/0000000243166612
- 700 1_
- $a Jeridi, Aicha $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Kim, Rinho $u Institute of Functional Epigenetics, Helmholtz Munich, 85764, Munich, Germany
- 700 1_
- $a Ertüz, Zeynep $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Lang, Niklas J $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Ansari, Meshal $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $u Institute of Computational Biology, Helmholtz Munich, 85764, Munich, Germany $1 https://orcid.org/0000000288197965
- 700 1_
- $a Novikova, Mariia $u Institute of Metabolism and Cell Death, Helmholtz Munich, 85764, Munich, Germany $u Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology, Ostrovityanova 1, Moscow, 117997, Russia $u Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Ostrovityanova1 bldg 10, 117997, Moscow, Russia
- 700 1_
- $a Jiang, Dongsheng $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $1 https://orcid.org/0000000309612671
- 700 1_
- $a Strunz, Maximilian $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Gaianova, Mariia $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Hollauer, Christine $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Gabriel, Christina $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Angelidis, Ilias $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Doll, Sebastian $u Institute of Computational Biology, Helmholtz Munich, 85764, Munich, Germany
- 700 1_
- $a Pestoni, Jeanine C $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Edelmann, Stephanie L $u Research Unit Molecular Immune Regulation, Helmholtz Munich, 81377, Munich, Germany
- 700 1_
- $a Kohlhepp, Marlene Sophia $u Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), 13353, Berlin, Germany
- 700 1_
- $a Guillot, Adrien $u Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), 13353, Berlin, Germany $1 https://orcid.org/0000000260029986
- 700 1_
- $a Bassler, Kevin $u Department for Genomics & Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany $u aimed analytics, 53121, Bonn, Germany
- 700 1_
- $a Van Eeckhoutte, Hannelore P $u Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University, University Hospital Ghent, 9000, Ghent, Belgium
- 700 1_
- $a Kayalar, Özgecan $u Koç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey $1 https://orcid.org/0000000191072381
- 700 1_
- $a Konyalilar, Nur $u Koç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey $1 https://orcid.org/0000000336936508
- 700 1_
- $a Kanashova, Tamara $u Max-Delbrück Center for Molecular Medicine, 13125, Berlin, Germany
- 700 1_
- $a Rodius, Sophie $u Proteomics of cellular signalling, Luxembourg Institute of Health, 1272, Strassen, Luxembourg
- 700 1_
- $a Ballester-López, Carolina $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Genes Robles, Carlos M $u Institute of Functional Epigenetics, Helmholtz Munich, 85764, Munich, Germany
- 700 1_
- $a Smirnova, Natalia $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $u Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, CO, 80045, USA
- 700 1_
- $a Rehberg, Markus $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Agarwal, Charu $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Krikki, Ioanna $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Piavaux, Benoit $u Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, 25242, Vestec, Czech Republic
- 700 1_
- $a Verleden, Stijn E $u Division of Pneumology, KU Leuven, 3000, Leuven, Belgium $u Antwerp Surgical Training, Anatomy and Research Centre, University of Antwerp, 2650, Edegem, Belgium
- 700 1_
- $a Vanaudenaerde, Bart $u Division of Pneumology, KU Leuven, 3000, Leuven, Belgium
- 700 1_
- $a Königshoff, Melanie $u Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA
- 700 1_
- $a Dittmar, Gunnar $u Proteomics of cellular signalling, Luxembourg Institute of Health, 1272, Strassen, Luxembourg $u Faculty of Science, Technology and Medicine, University of Luxembourg, L-4365, Esch-sur-Alzette, Luxembourg $1 https://orcid.org/0000000336478623
- 700 1_
- $a Bracke, Ken R $u Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University, University Hospital Ghent, 9000, Ghent, Belgium $1 https://orcid.org/0000000159064605
- 700 1_
- $a Schultze, Joachim L $u Department for Genomics & Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany $u Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., PRECISE Platform for Single Cell Genomics and Epigenomics at DZNE and the University of Bonn, 53115, Bonn, Germany
- 700 1_
- $a Watz, Henrik $u Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), 22927, Grosshansdorf, Germany
- 700 1_
- $a Eickelberg, Oliver $u Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA
- 700 1_
- $a Stoeger, Tobias $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany
- 700 1_
- $a Burgstaller, Gerald $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $1 https://orcid.org/0000000271212567
- 700 1_
- $a Tacke, Frank $u Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), 13353, Berlin, Germany $1 https://orcid.org/0000000162060226
- 700 1_
- $a Heissmeyer, Vigo $u Research Unit Molecular Immune Regulation, Helmholtz Munich, 81377, Munich, Germany $u Institute for Immunology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, 82152, Planegg-Martinsried, Germany
- 700 1_
- $a Rinkevich, Yuval $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $1 https://orcid.org/0000000336580257
- 700 1_
- $a Bayram, Hasan $u Koç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey $1 https://orcid.org/000000025236766X
- 700 1_
- $a Schiller, Herbert B $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany $1 https://orcid.org/0000000194987034
- 700 1_
- $a Conrad, Marcus $u Institute of Metabolism and Cell Death, Helmholtz Munich, 85764, Munich, Germany $u Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology, Ostrovityanova 1, Moscow, 117997, Russia $1 https://orcid.org/0000000311405612
- 700 1_
- $a Schneider, Robert $u Institute of Functional Epigenetics, Helmholtz Munich, 85764, Munich, Germany
- 700 1_
- $a Yildirim, Ali Önder $u Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany. oender.yildirim@helmholtz-muenchen.de $u Koç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey. oender.yildirim@helmholtz-muenchen.de $1 https://orcid.org/000000031969480X
- 773 0_
- $w MED00184850 $t Nature communications $x 2041-1723 $g Roč. 13, č. 1 (2022), s. 1303
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35288557 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220720 $b ABA008
- 991 __
- $a 20220804135417 $b ABA008
- 999 __
- $a ok $b bmc $g 1822684 $s 1170434
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 13 $c 1 $d 1303 $e 20220314 $i 2041-1723 $m Nature communications $n Nat Commun $x MED00184850
- LZP __
- $a Pubmed-20220720
