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Autor
Agarwal, Charu 1 Angelidis, Ilias 1 Ansari, Meshal 1 Ballester-López, Carolina 1 Bassler, Kevin 1 Bayram, Hasan 1 Bracke, Ken R 1 Burgstaller, Gerald 1 Conlon, Thomas M 1 Conrad, Marcus 1 Dittmar, Gunnar 1 Doll, Sebastian 1 Edelmann, Stephanie L 1 Eickelberg, Oliver 1 Ertüz, Zeynep 1 Gabriel, Christina 1 Gaianova, Mariia 1 Genes Robles, Carlos M 1 Guillot, Adrien 1 Günes Günsel, Gizem 1
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Pracoviště
Antwerp Surgical Training Anatomy and... 1 Czech Centre for Phenogenomics Instit... 1 Department for Genomics and Immunoreg... 1 Department of Hepatology and Gastroen... 1 Deutsches Zentrum für Neurodegenerati... 1 Division of Pneumology KU Leuven 3000... 1 Division of Pulmonary Allergy and Cri... 1 Division of Pulmonary Sciences and Cr... 1 Faculty of Science Technology and Med... 1 Federal Center of Brain Research and ... 1 Institute for Immunology Biomedical C... 1 Institute of Computational Biology He... 1 Institute of Functional Epigenetics H... 1 Institute of Lung Health and Immunity... 1 Institute of Metabolism and Cell Deat... 1 Koç University Research Center for Tr... 1 Laboratory for Translational Research... 1 Max Delbrück Center for Molecular Med... 1 Pirogov Russian National Research Med... 1 Proteomics of cellular signalling Lux... 1
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Autor
Agarwal, Charu 1 Angelidis, Ilias 1 Ansari, Meshal 1 Ballester-López, Carolina 1 Bassler, Kevin 1 Bayram, Hasan 1 Bracke, Ken R 1 Burgstaller, Gerald 1 Conlon, Thomas M 1 Conrad, Marcus 1 Dittmar, Gunnar 1 Doll, Sebastian 1 Edelmann, Stephanie L 1 Eickelberg, Oliver 1 Ertüz, Zeynep 1 Gabriel, Christina 1 Gaianova, Mariia 1 Genes Robles, Carlos M 1 Guillot, Adrien 1 Günes Günsel, Gizem 1
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Pracoviště
Antwerp Surgical Training Anatomy and... 1 Czech Centre for Phenogenomics Instit... 1 Department for Genomics and Immunoreg... 1 Department of Hepatology and Gastroen... 1 Deutsches Zentrum für Neurodegenerati... 1 Division of Pneumology KU Leuven 3000... 1 Division of Pulmonary Allergy and Cri... 1 Division of Pulmonary Sciences and Cr... 1 Faculty of Science Technology and Med... 1 Federal Center of Brain Research and ... 1 Institute for Immunology Biomedical C... 1 Institute of Computational Biology He... 1 Institute of Functional Epigenetics H... 1 Institute of Lung Health and Immunity... 1 Institute of Metabolism and Cell Deat... 1 Koç University Research Center for Tr... 1 Laboratory for Translational Research... 1 Max Delbrück Center for Molecular Med... 1 Pirogov Russian National Research Med... 1 Proteomics of cellular signalling Lux... 1
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- Günes Günsel, Gizem
- Conlon, Thomas M
- Jeridi, Aicha
- Kim, Rinho
- Ertüz, Zeynep
- Lang, Niklas J
- Ansari, Meshal
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Novikova, Mariia
Autor Novikova, Mariia Institute of Metabolism and Cell Death, Helmholtz Munich, 85764, Munich, Germany Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology, Ostrovityanova 1, Moscow, 117997, Russia Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Ostrovityanova1 bldg 10, 117997, Moscow, Russia
- Jiang, Dongsheng
- Strunz, Maximilian
Free Medical Journals od 2010
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PubMed Central od 2012
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ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
35288557
DOI
10.1038/s41467-022-28809-4
Knihovny.cz E-zdroje
Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic factor that has the capacity to mono-methylate histones on arginine residues. Here we show that in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression is elevated in the lung tissue and localized to the macrophages. In mouse models of COPD, lung fibrosis and skin injury, reduced expression of PRMT7 associates with decreased recruitment of monocytes to the site of injury and hence less severe symptoms. Mechanistically, activation of NF-κB/RelA in monocytes induces PRMT7 transcription and consequential mono-methylation of histones at the regulatory elements of RAP1A, which leads to increased transcription of this gene that is responsible for adhesion and migration of monocytes. Persistent monocyte-derived macrophage accumulation leads to ALOX5 over-expression and accumulation of its metabolite LTB4, which triggers expression of ACSL4 a ferroptosis promoting gene in lung epithelial cells. Conclusively, inhibition of arginine mono-methylation might offer targeted intervention in monocyte-driven inflammatory conditions that lead to extensive tissue damage if left untreated.
- MeSH
- arginin metabolismus MeSH
- chronická obstrukční plicní nemoc * genetika MeSH
- histony metabolismus MeSH
- intracelulární signální peptidy a proteiny MeSH
- lidé MeSH
- monocyty metabolismus MeSH
- myši MeSH
- proteinarginin-N-methyltransferasy * metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
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