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Polygenic risk modeling for prediction of epithelial ovarian cancer risk

EO. Dareng, JP. Tyrer, DR. Barnes, MR. Jones, X. Yang, KKH. Aben, MA. Adank, S. Agata, IL. Andrulis, H. Anton-Culver, NN. Antonenkova, G. Aravantinos, BK. Arun, A. Augustinsson, J. Balmaña, EV. Bandera, RB. Barkardottir, D. Barrowdale, MW....

. 2022 ; 30 (3) : 349-362. [pub] 20220114

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019276

Grantová podpora
15601 Cancer Research UK - United Kingdom
P20 GM130423 NIGMS NIH HHS - United States
P30 CA008748 NCI NIH HHS - United States

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PubMed Central od 2009 do Před 1 rokem
Europe PubMed Central od 2009 do Před 1 rokem
ProQuest Central od 2000-01-01 do Před 1 rokem
Open Access Digital Library od 1998-01-01
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, "select and shrink for summary statistics" (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28-1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08-1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21-1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29-1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35-1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.

'Agii Anargiri' Cancer Hospital Athens Greece

Aalborg University Department of Clinical Medicine Aalborg Denmark

Aalborg University Hospital Clinical Cancer Research Center Aalborg Denmark

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Citace poskytuje Crossref.org

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$a Polygenic risk modeling for prediction of epithelial ovarian cancer risk / $c EO. Dareng, JP. Tyrer, DR. Barnes, MR. Jones, X. Yang, KKH. Aben, MA. Adank, S. Agata, IL. Andrulis, H. Anton-Culver, NN. Antonenkova, G. Aravantinos, BK. Arun, A. Augustinsson, J. Balmaña, EV. Bandera, RB. Barkardottir, D. Barrowdale, MW. Beckmann, A. Beeghly-Fadiel, J. Benitez, M. Bermisheva, MQ. Bernardini, L. Bjorge, A. Black, NV. Bogdanova, B. Bonanni, A. Borg, JD. Brenton, A. Budzilowska, R. Butzow, SS. Buys, H. Cai, MA. Caligo, I. Campbell, R. Cannioto, H. Cassingham, J. Chang-Claude, SJ. Chanock, K. Chen, YE. Chiew, WK. Chung, KBM. Claes, S. Colonna, GEMO Study Collaborators, GC-HBOC Study Collaborators, EMBRACE Collaborators, LS. Cook, FJ. Couch, MB. Daly, F. Dao, E. Davies, M. de la Hoya, R. de Putter, J. Dennis, A. DePersia, P. Devilee, O. Diez, YC. Ding, JA. Doherty, SM. Domchek, T. Dörk, A. du Bois, M. Dürst, DM. Eccles, HA. Eliassen, C. Engel, GD. Evans, PA. Fasching, JM. Flanagan, RT. Fortner, E. Machackova, E. Friedman, PA. Ganz, J. Garber, F. Gensini, GG. Giles, G. Glendon, AK. Godwin, MT. Goodman, MH. Greene, J. Gronwald, OPAL Study Group, AOCS Group, E. Hahnen, CA. Haiman, N. Håkansson, U. Hamann, TVO. Hansen, HR. Harris, M. Hartman, F. Heitz, MAT. Hildebrandt, E. Høgdall, CK. Høgdall, JL. Hopper, RY. Huang, C. Huff, PJ. Hulick, DG. Huntsman, EN. Imyanitov, KConFab Investigators, HEBON Investigators, C. Isaacs, A. Jakubowska, PA. James, R. Janavicius, A. Jensen, OT. Johannsson, EM. John, ME. Jones, D. Kang, BY. Karlan, A. Karnezis, LE. Kelemen, E. Khusnutdinova, LA. Kiemeney, BG. Kim, SK. Kjaer, I. Komenaka, J. Kupryjanczyk, AW. Kurian, A. Kwong, D. Lambrechts, MC. Larson, C. Lazaro, ND. Le, G. Leslie, J. Lester, F. Lesueur, DA. Levine, L. Li, J. Li, JT. Loud, KH. Lu, J. Lubiński, PL. Mai, S. Manoukian, JR. Marks, RK. Matsuno, K. Matsuo, T. May, L. McGuffog, JR. McLaughlin, IA. McNeish, N. Mebirouk, U. Menon, A. Miller, RL. Milne, A. Minlikeeva, F. Modugno, M. Montagna, KB. Moysich, E. Munro, KL. Nathanson, SL. Neuhausen, H. Nevanlinna, JNY. Yie, HR. Nielsen, FC. Nielsen, L. Nikitina-Zake, K. Odunsi, K. Offit, E. Olah, S. Olbrecht, OI. Olopade, SH. Olson, H. Olsson, A. Osorio, L. Papi, SK. Park, MT. Parsons, H. Pathak, IS. Pedersen, A. Peixoto, T. Pejovic, P. Perez-Segura, JB. Permuth, B. Peshkin, P. Peterlongo, A. Piskorz, D. Prokofyeva, P. Radice, J. Rantala, MJ. Riggan, HA. Risch, C. Rodriguez-Antona, E. Ross, MA. Rossing, I. Runnebaum, DP. Sandler, M. Santamariña, P. Soucy, RK. Schmutzler, VW. Setiawan, K. Shan, W. Sieh, J. Simard, CF. Singer, AP. Sokolenko, H. Song, MC. Southey, H. Steed, D. Stoppa-Lyonnet, R. Sutphen, AJ. Swerdlow, YY. Tan, MR. Teixeira, SH. Teo, KL. Terry, MB. Terry, OCAC Consortium, CIMBA Consortium, M. Thomassen, PJ. Thompson, LCV. Thomsen, DL. Thull, M. Tischkowitz, L. Titus, AE. Toland, D. Torres, B. Trabert, R. Travis, N. Tung, SS. Tworoger, E. Valen, AM. van Altena, AH. van der Hout, E. Van Nieuwenhuysen, EJ. van Rensburg, A. Vega, DV. Edwards, RA. Vierkant, F. Wang, B. Wappenschmidt, PM. Webb, CR. Weinberg, JN. Weitzel, N. Wentzensen, E. White, AS. Whittemore, SJ. Winham, A. Wolk, YL. Woo, AH. Wu, L. Yan, D. Yannoukakos, KM. Zavaglia, W. Zheng, A. Ziogas, KK. Zorn, Z. Kleibl, D. Easton, K. Lawrenson, A. DeFazio, TA. Sellers, SJ. Ramus, CL. Pearce, AN. Monteiro, J. Cunningham, EL. Goode, JM. Schildkraut, A. Berchuck, G. Chenevix-Trench, SA. Gayther, AC. Antoniou, PDP. Pharoah
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$a Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, "select and shrink for summary statistics" (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28-1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08-1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21-1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29-1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35-1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.
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$a Tyrer, Jonathan P $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK $1 https://orcid.org/0000000337244757
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$a Yang, Xin $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK $1 https://orcid.org/0000000300373790
700    1_
$a Aben, Katja K H $u Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands $u Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands
700    1_
$a Adank, Muriel A $u The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Family Cancer Clinic, Amsterdam, The Netherlands
700    1_
$a Agata, Simona $u Veneto Institute of Oncology IOV-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy
700    1_
$a Andrulis, Irene L $u Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada $u University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada $1 https://orcid.org/0000000242266435
700    1_
$a Anton-Culver, Hoda $u University of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA, USA
700    1_
$a Antonenkova, Natalia N $u N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus
700    1_
$a Aravantinos, Gerasimos $u 'Agii Anargiri' Cancer Hospital, Athens, Greece
700    1_
$a Arun, Banu K $u University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, TX, USA
700    1_
$a Augustinsson, Annelie $u Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden $1 https://orcid.org/0000000334150536
700    1_
$a Balmaña, Judith $u Vall d'Hebron Institute of Oncology, Hereditary cancer Genetics Group, Barcelona, Spain $u University Hospital of Vall d'Hebron, Department of Medical Oncology, Barcelona, Spain
700    1_
$a Bandera, Elisa V $u Rutgers Cancer Institute of New Jersey, Cancer Prevention and Control Program, New Brunswick, NJ, USA
700    1_
$a Barkardottir, Rosa B $u Landspitali University Hospital, Department of Pathology, Reykjavik, Iceland $u University of Iceland, BMC (Biomedical Centre), Faculty of Medicine, Reykjavik, Iceland
700    1_
$a Barrowdale, Daniel $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK $1 https://orcid.org/0000000316613939
700    1_
$a Beckmann, Matthias W $u University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany
700    1_
$a Beeghly-Fadiel, Alicia $u Vanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA
700    1_
$a Benitez, Javier $u Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain $u Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain
700    1_
$a Bermisheva, Marina $u Ufa Federal Research Centre of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia
700    1_
$a Bernardini, Marcus Q $u Princess Margaret Hospital, Division of Gynecologic Oncology, University Health Network, Toronto, ON, Canada
700    1_
$a Bjorge, Line $u Haukeland University Hospital, Department of Obstetrics and Gynecology, Bergen, Norway $u University of Bergen, Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, Bergen, Norway
700    1_
$a Black, Amanda $u National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
700    1_
$a Bogdanova, Natalia V $u N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus $u Hannover Medical School, Department of Radiation Oncology, Hannover, Germany $u Hannover Medical School, Gynaecology Research Unit, Hannover, Germany
700    1_
$a Bonanni, Bernardo $u IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, Italy $1 https://orcid.org/0000000335892128
700    1_
$a Borg, Ake $u Lund University and Skåne University Hospital, Department of Oncology, Lund, Sweden
700    1_
$a Brenton, James D $u Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK $1 https://orcid.org/0000000257386683
700    1_
$a Budzilowska, Agnieszka $u Maria Sklodowska-Curie National Research Institute of Oncology, Department of Pathology and Laboratory Diagnostics, Warsaw, Poland
700    1_
$a Butzow, Ralf $u University of Helsinki, Department of Pathology, Helsinki University Hospital, Helsinki, Finland $1 https://orcid.org/0000000343665099
700    1_
$a Buys, Saundra S $u Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT, USA
700    1_
$a Cai, Hui $u Vanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA
700    1_
$a Caligo, Maria A $u University Hospital, SOD Genetica Molecolare, Pisa, Italy
700    1_
$a Campbell, Ian $u Peter MacCallum Cancer Center, Melbourne, VIC, Australia $u The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia $1 https://orcid.org/0000000277734155
700    1_
$a Cannioto, Rikki $u Roswell Park Cancer Institute, Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Buffalo, NY, USA
700    1_
$a Cassingham, Hayley $u Division of Human Genetics, The Ohio State University, Department of Internal Medicine, Columbus, OH, USA
700    1_
$a Chang-Claude, Jenny $u German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany $u University Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany
700    1_
$a Chanock, Stephen J $u National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA $1 https://orcid.org/0000000223243393
700    1_
$a Chen, Kexin $u Tianjin Medical University Cancer Institute and Hospital, Department of Epidemiology, Tianjin, China
700    1_
$a Chiew, Yoke-Eng $u The University of Sydney, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia $u Westmead Hospital, Department of Gynaecological Oncology, Sydney, NSW, Australia
700    1_
$a Chung, Wendy K $u Columbia University, Departments of Pediatrics and Medicine, New York, NY, USA
700    1_
$a Claes, Kathleen B M $u Ghent University, Centre for Medical Genetics, Gent, Belgium $1 https://orcid.org/0000000308417372
700    1_
$a Colonna, Sarah $u Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT, USA
700    1_
$a Cook, Linda S $u University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA $u Alberta Health Services, Department of Cancer Epidemiology and Prevention Research, Calgary, AB, Canada
700    1_
$a Couch, Fergus J $u Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA
700    1_
$a Daly, Mary B $u Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA, USA
700    1_
$a Dao, Fanny $u Memorial Sloan Kettering Cancer Center, Gynecology Service, Department of Surgery, New York, NY, USA
700    1_
$a Davies, Eleanor $u Cambridge, Cambridge, UK
700    1_
$a de la Hoya, Miguel $u CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Molecular Oncology Laboratory, Madrid, Spain $1 https://orcid.org/0000000281131410
700    1_
$a de Putter, Robin $u Ghent University, Centre for Medical Genetics, Gent, Belgium $1 https://orcid.org/0000000194108941
700    1_
$a Dennis, Joe $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK $1 https://orcid.org/0000000345911214
700    1_
$a DePersia, Allison $u NorthShore University Health System, Center for Medical Genetics, Evanston, IL, USA $u The University of Chicago Pritzker School of Medicine, Chicago, IL, USA
700    1_
$a Devilee, Peter $u Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands $u Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands $1 https://orcid.org/0000000280232009
700    1_
$a Diez, Orland $u Vall dHebron Institute of Oncology (VHIO), Oncogenetics Group, Barcelona, Spain $u University Hospital Vall dHebron, Clinical and Molecular Genetics Area, Barcelona, Spain
700    1_
$a Ding, Yuan Chun $u Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA
700    1_
$a Doherty, Jennifer A $u University of Utah, Huntsman Cancer Institute, Department of Population Health Sciences, Salt Lake City, UT, USA
700    1_
$a Domchek, Susan M $u University of Pennsylvania, Basser Center for BRCA, Abramson Cancer Center, Philadelphia, PA, USA
700    1_
$a Dörk, Thilo $u Hannover Medical School, Gynaecology Research Unit, Hannover, Germany
700    1_
$a du Bois, Andreas $u Ev. Kliniken Essen-Mitte (KEM), Department of Gynecology and Gynecologic Oncology, Essen, Germany $u Dr. Horst Schmidt Kliniken Wiesbaden, Department of Gynecology and Gynecologic Oncology, Wiesbaden, Germany $1 https://orcid.org/000000028477506X
700    1_
$a Dürst, Matthias $u Jena University Hospital-Friedrich Schiller University, Department of Gynaecology, Jena, Germany
700    1_
$a Eccles, Diana M $u University of Southampton, Faculty of Medicine, Southampton, UK
700    1_
$a Eliassen, Heather A $u Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA $u Brigham and Women's Hospital and Harvard Medical School, Channing Division of Network Medicine, Boston, MA, USA
700    1_
$a Engel, Christoph $u University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany $u University of Leipzig, LIFE-Leipzig Research Centre for Civilization Diseases, Leipzig, Germany
700    1_
$a Evans, Gareth D $u University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK $u St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester, UK
700    1_
$a Fasching, Peter A $u University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany $u University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, Los Angeles, CA, USA
700    1_
$a Flanagan, James M $u Imperial College London, Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, London, UK
700    1_
$a Fortner, Renée T $u German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
700    1_
$a Machackova, Eva $u Masaryk Memorial Cancer Institute, Department of Cancer Epidemiology and Genetics, Brno, Czech Republic $1 https://orcid.org/0000000202461471
700    1_
$a Friedman, Eitan $u Chaim Sheba Medical Center, The Susanne Levy Gertner Oncogenetics Unit, Ramat Gan, Israel $u Tel Aviv University, Sackler Faculty of Medicine, Ramat Aviv, Israel
700    1_
$a Ganz, Patricia A $u Jonsson Comprehensive Cancer Centre, UCLA, Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Los Angeles, CA, USA
700    1_
$a Garber, Judy $u Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA, USA
700    1_
$a Gensini, Francesca $u University of Florence, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, Florence, Italy
700    1_
$a Giles, Graham G $u Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia $u The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia $u Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia $1 https://orcid.org/0000000349469099
700    1_
$a Glendon, Gord $u Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada
700    1_
$a Godwin, Andrew K $u University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, USA $1 https://orcid.org/0000000239879580
700    1_
$a Goodman, Marc T $u Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Los Angeles, CA, USA
700    1_
$a Greene, Mark H $u National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA $1 https://orcid.org/0000000318529239
700    1_
$a Gronwald, Jacek $u Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland
700    1_
$a Hahnen, Eric $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne, Germany $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany
700    1_
$a Haiman, Christopher A $u University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA
700    1_
$a Håkansson, Niclas $u Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden
700    1_
$a Hamann, Ute $u German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany
700    1_
$a Hansen, Thomas V O $u Rigshospitalet, Copenhagen University Hospital, Department of Clinical Genetics, Copenhagen, Denmark
700    1_
$a Harris, Holly R $u Fred Hutchinson Cancer Research Center, Program in Epidemiology, Division of Public Health Sciences, Seattle, WA, USA $u University of Washington, Department of Epidemiology, Seattle, WA, USA
700    1_
$a Hartman, Mikael $u National University of Singapore and National University Health System, Saw Swee Hock School of Public Health, Singapore, Singapore $u National University Health System, Department of Surgery, Singapore, Singapore
700    1_
$a Heitz, Florian $u Ev. Kliniken Essen-Mitte (KEM), Department of Gynecology and Gynecologic Oncology, Essen, Germany $u Dr. Horst Schmidt Kliniken Wiesbaden, Department of Gynecology and Gynecologic Oncology, Wiesbaden, Germany $u Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany $1 https://orcid.org/0000000224120352
700    1_
$a Hildebrandt, Michelle A T $u University of Texas MD Anderson Cancer Center, Department of Epidemiology, Houston, TX, USA
700    1_
$a Høgdall, Estrid $u Danish Cancer Society Research Center, Department of Virus, Lifestyle and Genes, Copenhagen, Denmark $u University of Copenhagen, Molecular Unit, Department of Pathology, Herlev Hospital, Copenhagen, Denmark
700    1_
$a Høgdall, Claus K $u University of Copenhagen, Department of Gynaecology, Rigshospitalet, Copenhagen, Denmark
700    1_
$a Hopper, John L $u The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia
700    1_
$a Huang, Ruea-Yea $u Roswell Park Cancer Institute, Center For Immunotherapy, Buffalo, NY, USA
700    1_
$a Huff, Chad $u University of Texas MD Anderson Cancer Center, Department of Epidemiology, Houston, TX, USA
700    1_
$a Hulick, Peter J $u NorthShore University Health System, Center for Medical Genetics, Evanston, IL, USA $u The University of Chicago Pritzker School of Medicine, Chicago, IL, USA $1 https://orcid.org/0000000183974078
700    1_
$a Huntsman, David G $u BC Cancer, Vancouver General Hospital, and University of British Columbia, British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver, BC, Canada $u University of British Columbia, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada $u University of British Columbia, Department of Obstetrics and Gynecology, Vancouver, BC, Canada $u BC Cancer Research Centre, Department of Molecular Oncology, Vancouver, BC, Canada
700    1_
$a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia
700    1_
$a Isaacs, Claudine $u Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
700    1_
$a Jakubowska, Anna $u Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland $u Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland $1 https://orcid.org/0000000256500501
700    1_
$a James, Paul A $u The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia $u Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC, Australia $1 https://orcid.org/0000000243614657
700    1_
$a Janavicius, Ramunas $u Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius, Lithuania $u State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
700    1_
$a Jensen, Allan $u Danish Cancer Society Research Center, Department of Virus, Lifestyle and Genes, Copenhagen, Denmark
700    1_
$a Johannsson, Oskar Th $u Landspitali University Hospital, Department of Oncology, Reykjavik, Iceland
700    1_
$a John, Esther M $u Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA, USA $u Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, USA
700    1_
$a Jones, Michael E $u The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK
700    1_
$a Kang, Daehee $u Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, Korea $u Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, Korea $u Seoul National University, Cancer Research Institute, Seoul, Korea
700    1_
$a Karlan, Beth Y $u University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA
700    1_
$a Karnezis, Anthony $u UC Davis Medical Center, Department of Pathology and Laboratory Medicine, Sacramento, CA, USA
700    1_
$a Kelemen, Linda E $u Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA
700    1_
$a Khusnutdinova, Elza $u Ufa Federal Research Centre of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia $u Saint Petersburg State University, Saint Petersburg, Russia
700    1_
$a Kiemeney, Lambertus A $u Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands $1 https://orcid.org/0000000223681326
700    1_
$a Kim, Byoung-Gie $u Sungkyunkwan University School of Medicine, Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea
700    1_
$a Kjaer, Susanne K $u Danish Cancer Society Research Center, Department of Virus, Lifestyle and Genes, Copenhagen, Denmark $u University of Copenhagen, Department of Gynaecology, Rigshospitalet, Copenhagen, Denmark
700    1_
$a Komenaka, Ian $u City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA
700    1_
$a Kupryjanczyk, Jolanta $u Maria Sklodowska-Curie National Research Institute of Oncology, Department of Pathology and Laboratory Diagnostics, Warsaw, Poland
700    1_
$a Kurian, Allison W $u Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA, USA $u Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, USA $1 https://orcid.org/0000000261759470
700    1_
$a Kwong, Ava $u Cancer Genetics Centre, Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong $u The University of Hong Kong, Department of Surgery, Pok Fu Lam, Hong Kong $u Hong Kong Sanatorium and Hospital, Department of Surgery, Happy Valley, Hong Kong
700    1_
$a Lambrechts, Diether $u VIB Center for Cancer Biology, Leuven, Belgium $u University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium $1 https://orcid.org/000000023429302X
700    1_
$a Larson, Melissa C $u Mayo Clinic, Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Rochester, MN, USA
700    1_
$a Lazaro, Conxi $u ONCOBELL-IDIBELL-IGTP, Catalan Institute of Oncology, CIBERONC, Hereditary Cancer Program, Barcelona, Spain $1 https://orcid.org/0000000271985906
700    1_
$a Le, Nhu D $u BC Cancer, Cancer Control Research, Vancouver, BC, Canada
700    1_
$a Leslie, Goska $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK $1 https://orcid.org/0000000157566222
700    1_
$a Lester, Jenny $u University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA
700    1_
$a Lesueur, Fabienne $u Institut Curie, Paris, France $u Mines ParisTech, Fontainebleau, France $u Inserm U900, Genetic Epidemiology of Cancer team, Paris, France $1 https://orcid.org/0000000174044549
700    1_
$a Levine, Douglas A $u Memorial Sloan Kettering Cancer Center, Gynecology Service, Department of Surgery, New York, NY, USA $u NYU Langone Medical Center, Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, New York, NY, USA
700    1_
$a Li, Lian $u Tianjin Medical University Cancer Institute and Hospital, Department of Epidemiology, Tianjin, China
700    1_
$a Li, Jingmei $u Genome Institute of Singapore, Human Genetics Division, Singapore, Singapore
700    1_
$a Loud, Jennifer T $u National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
700    1_
$a Lu, Karen H $u University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Clinical Cancer Genetics Program, Houston, TX, USA
700    1_
$a Lubiński, Jan $u Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland
700    1_
$a Mai, Phuong L $u Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA $1 https://orcid.org/0000000274864974
700    1_
$a Manoukian, Siranoush $u Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy
700    1_
$a Marks, Jeffrey R $u Duke University Hospital, Department of Surgery, Durham, NC, USA
700    1_
$a Matsuno, Rayna Kim $u University of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI, USA
700    1_
$a Matsuo, Keitaro $u Aichi Cancer Center Research Institute, Division of Cancer Epidemiology and Prevention, Nagoya, Japan $u Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya, Japan $1 https://orcid.org/0000000317616314
700    1_
$a May, Taymaa $u Princess Margaret Hospital, Division of Gynecologic Oncology, University Health Network, Toronto, ON, Canada
700    1_
$a McGuffog, Lesley $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK
700    1_
$a McLaughlin, John R $u Samuel Lunenfeld Research Institute, Public Health Ontario, Toronto, ON, Canada
700    1_
$a McNeish, Iain A $u Imperial College London, Division of Cancer and Ovarian Cancer Action Research Centre, Department Surgery & Cancer, London, UK $u University of Glasgow, Institute of Cancer Sciences, Glasgow, UK
700    1_
$a Mebirouk, Noura $u Institut Curie, Paris, France $u Mines ParisTech, Fontainebleau, France $u Inserm U900, Genetic Epidemiology of Cancer team, Paris, France
700    1_
$a Menon, Usha $u University College London, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, London, UK $1 https://orcid.org/0000000337081732
700    1_
$a Miller, Austin $u Roswell Park Cancer Institute, NRG Oncology, Statistics and Data Management Center, Buffalo, NY, USA
700    1_
$a Milne, Roger L $u Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia $u The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia $u Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia $1 https://orcid.org/0000000157647268
700    1_
$a Minlikeeva, Albina $u Roswell Park Cancer Institute, Division of Cancer Prevention and Control, Buffalo, NY, USA
700    1_
$a Modugno, Francesmary $u Magee-Womens Research Institute and Hillman Cancer Center, Womens Cancer Research Center, Pittsburgh, PA, USA $u University of Pittsburgh School of Medicine, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh, PA, USA
700    1_
$a Montagna, Marco $u Veneto Institute of Oncology IOV-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy
700    1_
$a Moysich, Kirsten B $u Roswell Park Cancer Institute, Division of Cancer Prevention and Control, Buffalo, NY, USA
700    1_
$a Munro, Elizabeth $u Oregon Health & Science University, Department of Obstetrics and Gynecology, Portland, OR, USA $u Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA
700    1_
$a Nathanson, Katherine L $u University of Pennsylvania, Basser Center for BRCA, Abramson Cancer Center, Philadelphia, PA, USA $1 https://orcid.org/0000000267400901
700    1_
$a Neuhausen, Susan L $u Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA
700    1_
$a Nevanlinna, Heli $u University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland $1 https://orcid.org/0000000209162976
700    1_
$a Yie, Joanne Ngeow Yuen $u National Cancer Centre, Cancer Genetics Service, Singapore, Singapore $u Nanyang Technological University, Lee Kong Chian School of Medicine, Singapore, Singapore $1 https://orcid.org/0000000315583627
700    1_
$a Nielsen, Henriette Roed $u Odense University Hospital, Department of Clinical Genetics, Odence C, Denmark
700    1_
$a Nielsen, Finn C $u Rigshospitalet, Copenhagen University Hospital, Department of Clinical Genetics, Copenhagen, Denmark
700    1_
$a Nikitina-Zake, Liene $u Latvian Biomedical Research and Study Centre, Riga, Latvia
700    1_
$a Odunsi, Kunle $u Roswell Park Cancer Institute, Department of Gynecologic Oncology, Buffalo, NY, USA
700    1_
$a Offit, Kenneth $u Memorial Sloan Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, USA $u Memorial Sloan Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA
700    1_
$a Olah, Edith $u National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary
700    1_
$a Olbrecht, Siel $u University Hospitals Leuven, Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, Leuven, Belgium
700    1_
$a Olopade, Olufunmilayo I $u The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL, USA $1 https://orcid.org/0000000299361599
700    1_
$a Olson, Sara H $u Memorial Sloan-Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA
700    1_
$a Olsson, Håkan $u Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden
700    1_
$a Osorio, Ana $u Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain $u Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain
700    1_
$a Papi, Laura $u University of Florence, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, Florence, Italy
700    1_
$a Park, Sue K $u Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, Korea $u Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, Korea $u Seoul National University, Cancer Research Institute, Seoul, Korea $1 https://orcid.org/0000000150029707
700    1_
$a Parsons, Michael T $u QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia $1 https://orcid.org/0000000332428477
700    1_
$a Pathak, Harsha $u University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, USA
700    1_
$a Pedersen, Inge Sokilde $u Aalborg University Hospital, Molecular Diagnostics, Aalborg, Denmark $u Aalborg University Hospital, Clinical Cancer Research Center, Aalborg, Denmark $u Aalborg University, Department of Clinical Medicine, Aalborg, Denmark $1 https://orcid.org/0000000299028040
700    1_
$a Peixoto, Ana $u Portuguese Oncology Institute, Department of Genetics, Porto, Portugal
700    1_
$a Pejovic, Tanja $u Oregon Health & Science University, Department of Obstetrics and Gynecology, Portland, OR, USA $u Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA
700    1_
$a Perez-Segura, Pedro $u CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Molecular Oncology Laboratory, Madrid, Spain
700    1_
$a Permuth, Jennifer B $u Moffitt Cancer Center, Department of Cancer Epidemiology, Tampa, FL, USA
700    1_
$a Peshkin, Beth $u Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA $1 https://orcid.org/0000000229974701
700    1_
$a Peterlongo, Paolo $u IFOM-the FIRC Institute of Molecular Oncology, Genome Diagnostics Program, Milan, Italy $1 https://orcid.org/0000000169516855
700    1_
$a Piskorz, Anna $u Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
700    1_
$a Prokofyeva, Darya $u Bashkir State University, Department of Genetics and Fundamental Medicine, Ufa, Russia
700    1_
$a Radice, Paolo $u Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy $1 https://orcid.org/0000000162984111
700    1_
$a Rantala, Johanna $u Karolinska Institutet, Clinical Genetics, Stockholm, Sweden
700    1_
$a Riggan, Marjorie J $u Duke University Hospital, Department of Gynecologic Oncology, Durham, NC, USA
700    1_
$a Risch, Harvey A $u Yale School of Public Health, Chronic Disease Epidemiology, New Haven, CT, USA
700    1_
$a Rodriguez-Antona, Cristina $u Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain $u Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain
700    1_
$a Ross, Eric $u Fox Chase Cancer Center, Population Studies Facility, Philadelphia, PA, USA $1 https://orcid.org/0000000208902418
700    1_
$a Rossing, Mary Anne $u Fred Hutchinson Cancer Research Center, Program in Epidemiology, Division of Public Health Sciences, Seattle, WA, USA $u University of Washington, Department of Epidemiology, Seattle, WA, USA
700    1_
$a Runnebaum, Ingo $u Jena University Hospital-Friedrich Schiller University, Department of Gynaecology, Jena, Germany
700    1_
$a Sandler, Dale P $u National Institute of Environmental Health Sciences, NIH, Epidemiology Branch, Research Triangle Park, NC, USA $1 https://orcid.org/0000000267760018
700    1_
$a Santamariña, Marta $u Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain $u Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain $u Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain
700    1_
$a Soucy, Penny $u Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Genomics Center, Québec City, QC, Canada
700    1_
$a Schmutzler, Rita K $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne, Germany $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany
700    1_
$a Setiawan, V Wendy $u University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA
700    1_
$a Shan, Kang $u Hebei Medical University, Fourth Hospital, Department of Obstetrics and Gynaecology, Shijiazhuang, China
700    1_
$a Sieh, Weiva $u Icahn School of Medicine at Mount Sinai, Department of Population Health Science and Policy, New York, NY, USA $u Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, NY, USA $1 https://orcid.org/0000000300851190
700    1_
$a Simard, Jacques $u Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Genomic Center, Québec City, QC, Canada $1 https://orcid.org/0000000169063390
700    1_
$a Singer, Christian F $u Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria
700    1_
$a Sokolenko, Anna P $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia
700    1_
$a Song, Honglin $u University of Cambridge, Department of Public Health and Primary Care, Cambridge, UK
700    1_
$a Southey, Melissa C $u Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia $u Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia $u The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC, Australia
700    1_
$a Steed, Helen $u Royal Alexandra Hospital, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Edmonton, AB, Canada
700    1_
$a Stoppa-Lyonnet, Dominique $u INSERM U830, Department of Tumour Biology, Paris, France $u Institut Curie, Service de Génétique, Paris, France $u Université Paris Descartes, Paris, France $1 https://orcid.org/0000000254388309
700    1_
$a Sutphen, Rebecca $u University of South Florida, Epidemiology Center, College of Medicine, Tampa, FL, USA
700    1_
$a Swerdlow, Anthony J $u The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK $u The Institute of Cancer Research, Division of Breast Cancer Research, London, UK
700    1_
$a Tan, Yen Yen $u Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria
700    1_
$a Teixeira, Manuel R $u Portuguese Oncology Institute, Department of Genetics, Porto, Portugal $u University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal $1 https://orcid.org/0000000248965982
700    1_
$a Teo, Soo Hwang $u Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, Malaysia $u University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, Malaysia $1 https://orcid.org/000000020444590X
700    1_
$a Terry, Kathryn L $u Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA $u Brigham and Women's Hospital and Harvard Medical School, Obstetrics and Gynecology Epidemiology Center, Boston, MA, USA
700    1_
$a Terry, Mary Beth $u Columbia University, Department of Epidemiology, Mailman School of Public Health, New York, NY, USA
700    1_
$a Thomassen, Mads $u Odense University Hospital, Department of Clinical Genetics, Odence C, Denmark
700    1_
$a Thompson, Pamela J $u Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Los Angeles, CA, USA
700    1_
$a Thomsen, Liv Cecilie Vestrheim $u Haukeland University Hospital, Department of Obstetrics and Gynecology, Bergen, Norway $u University of Bergen, Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, Bergen, Norway
700    1_
$a Thull, Darcy L $u Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA
700    1_
$a Tischkowitz, Marc $u McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC, Canada $u University of Cambridge, Department of Medical Genetics, Cambridge, UK $1 https://orcid.org/0000000278800628
700    1_
$a Titus, Linda $u Dartmouth College, Geisel School of Medicine, Hanover, NH, USA
700    1_
$a Toland, Amanda E $u The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, USA $1 https://orcid.org/0000000202711792
700    1_
$a Torres, Diana $u German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany $u Pontificia Universidad Javeriana, Institute of Human Genetics, Bogota, Colombia
700    1_
$a Trabert, Britton $u National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA $1 https://orcid.org/0000000215396090
700    1_
$a Travis, Ruth $u University of Oxford, Cancer Epidemiology Unit, Oxford, UK $1 https://orcid.org/0000000295710763
700    1_
$a Tung, Nadine $u Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA, USA
700    1_
$a Tworoger, Shelley S $u Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA $u Moffitt Cancer Center, Department of Cancer Epidemiology, Tampa, FL, USA $1 https://orcid.org/0000000269867046
700    1_
$a Valen, Ellen $u Haukeland University Hospital, Department of Obstetrics and Gynecology, Bergen, Norway $u University of Bergen, Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, Bergen, Norway
700    1_
$a van Altena, Anne M $u Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
700    1_
$a van der Hout, Annemieke H $u University Medical Center Groningen, University Groningen, Department of Genetics, Groningen, The Netherlands
700    1_
$a Van Nieuwenhuysen, Els $u University Hospitals Leuven, Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, Leuven, Belgium
700    1_
$a van Rensburg, Elizabeth J $u University of Pretoria, Department of Genetics, Arcadia, South Africa $1 https://orcid.org/000000032077230X
700    1_
$a Vega, Ana $u Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain $u Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain $u Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain
700    1_
$a Edwards, Digna Velez $u Vanderbilt University Medical Center, Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Women's Health Research, Nashville, TN, USA
700    1_
$a Vierkant, Robert A $u Mayo Clinic, Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Rochester, MN, USA
700    1_
$a Wang, Frances $u Duke Cancer Institute, Cancer Control and Population Sciences, Durham, NC, USA $u Duke University Hospital, Department of Community and Family Medicine, Durham, NC, USA
700    1_
$a Wappenschmidt, Barbara $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne, Germany $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany
700    1_
$a Webb, Penelope M $u QIMR Berghofer Medical Research Institute, Population Health Department, Brisbane, QLD, Australia $1 https://orcid.org/0000000307335930
700    1_
$a Weinberg, Clarice R $u National Institute of Environmental Health Sciences, NIH, Biostatistics and Computational Biology Branch, Research Triangle Park, NC, USA
700    1_
$a Weitzel, Jeffrey N $u City of Hope, Clinical Cancer Genomics, Duarte, CA, USA
700    1_
$a Wentzensen, Nicolas $u National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
700    1_
$a White, Emily $u University of Washington, Department of Epidemiology, Seattle, WA, USA $u Fred Hutchinson Cancer Research Center, Seattle, WA, USA
700    1_
$a Whittemore, Alice S $u Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA, USA $u Stanford University School of Medicine, Department of Biomedical Data Science, Stanford, CA, USA
700    1_
$a Winham, Stacey J $u Mayo Clinic, Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Rochester, MN, USA $1 https://orcid.org/0000000284929102
700    1_
$a Wolk, Alicja $u Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden $u Uppsala University, Department of Surgical Sciences, Uppsala, Sweden
700    1_
$a Woo, Yin-Ling $u University of Malaya, Department of Obstetrics and Gynaecology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia $1 https://orcid.org/0000000317421066
700    1_
$a Wu, Anna H $u University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA
700    1_
$a Yan, Li $u Hebei Medical University, Fourth Hospital, Department of Molecular Biology, Shijiazhuang, China
700    1_
$a Yannoukakos, Drakoulis $u National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece $1 https://orcid.org/0000000175093510
700    1_
$a Zavaglia, Katia M $u University Hospital, SOD Genetica Molecolare, Pisa, Italy
700    1_
$a Zheng, Wei $u Vanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA
700    1_
$a Ziogas, Argyrios $u University of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA, USA $1 https://orcid.org/0000000345293727
700    1_
$a Zorn, Kristin K $u Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
700    1_
$a Kleibl, Zdenek $u Institute of Biochemistry and Experimental Oncology, First Faculty od Medicine, Charles University, Prague, Czech Republic $1 https://orcid.org/0000000320509667
700    1_
$a Easton, Douglas $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK $1 https://orcid.org/0000000324443247
700    1_
$a Lawrenson, Kate $u Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA $u Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Centre, Department of Obstetrics and Gynecology, Los Angeles, CA, USA
700    1_
$a DeFazio, Anna $u The University of Sydney, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia $u Westmead Hospital, Department of Gynaecological Oncology, Sydney, NSW, Australia $1 https://orcid.org/0000000300574744
700    1_
$a Sellers, Thomas A $u Royal Pass Road, Tampa, FL, USA
700    1_
$a Ramus, Susan J $u University of NSW Sydney, School of Women's and Children's Health, Faculty of Medicine, Sydney, NSW, Australia $u University of NSW Sydney, Adult Cancer Program, Lowy Cancer Research Centre, Sydney, NSW, Australia $1 https://orcid.org/0000000300057798
700    1_
$a Pearce, Celeste L $u University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA $u University of Southern California Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA
700    1_
$a Monteiro, Alvaro N $u Moffitt Cancer Center, Department of Cancer Epidemiology, Tampa, FL, USA $1 https://orcid.org/0000000284484801
700    1_
$a Cunningham, Julie $u Mayo Clinic, Department of Health Science Research, Division of Epidemiology, Rochester, MN, USA $1 https://orcid.org/0000000281593025
700    1_
$a Goode, Ellen L $u Mayo Clinic, Department of Health Science Research, Division of Epidemiology, Rochester, MN, USA
700    1_
$a Schildkraut, Joellen M $u Emory University, Department of Epidemiology, Rollins School of Public Health, Atlanta, GA, USA
700    1_
$a Berchuck, Andrew $u Duke University Hospital, Department of Gynecologic Oncology, Durham, NC, USA
700    1_
$a Chenevix-Trench, Georgia $u QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia
700    1_
$a Gayther, Simon A $u Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA $1 https://orcid.org/0000000179375443
700    1_
$a Antoniou, Antonis C $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK
700    1_
$a Pharoah, Paul D P $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK. pp10001@medschl.cam.ac.uk $u University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK. pp10001@medschl.cam.ac.uk $1 https://orcid.org/000000018494732X
710    2_
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710    2_
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710    2_
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710    2_
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710    2_
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710    2_
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710    2_
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710    2_
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710    2_
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