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Long-term outcome after living donor liver transplantation compared to donation after brain death in autoimmune liver diseases: Experience from the European Liver Transplant Registry
M. Heinemann, T. Liwinski, R. Adam, M. Berenguer, D. Mirza, SA. Malek-Hosseini, MA. Heneghan, P. Lodge, J. Pratschke, K. Boudjema, A. Paul, K. Zieniewicz, J. Fronek, A. Mehrabi, K. Acarli, Y. Tokat, A. Coker, S. Yilmaz, V. Karam, C. Duvoux, AW....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 2001 do 2022
Wiley Free Content
od 2001 do 2022
ROAD: Directory of Open Access Scholarly Resources
od 2001
PubMed
34605157
DOI
10.1111/ajt.16864
Knihovny.cz E-zdroje
- MeSH
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mozková smrt MeSH
- nemoci jater * etiologie MeSH
- přežívání štěpu MeSH
- registrace MeSH
- retrospektivní studie MeSH
- transplantace jater * škodlivé účinky MeSH
- výsledek terapie MeSH
- žijící dárci MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Knowledge of living donor liver transplantation (LDLT) for autoimmune liver diseases (AILDs) is scarce. This study analyzed survival in LDLT recipients registered in the European Liver Transplant Registry with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis (PSC) and the non-autoimmune disorder alcohol-related cirrhosis. In total, 29 902 individuals enrolled between 1998 and 2017 were analyzed, including 1003 with LDLT. Survival from >90 days after LDLT for AILDs in adults was 85.5%, 74.2%, and 58.0% after 5, 10, and 15 years. Adjusted for recipient age, sex, and liver transplantation era, adult PSC patients receiving LDLT showed increased mortality compared to donation after brain death (DBD) (hazard ratio [HR] = 1.95, 95% confidence interval [CI] = 1.36-2.80, p < .001). Pediatric PSC patients showed also increased mortality >90 days after LDLT compared to DBD (HR = 3.00, 95% CI 1.04-8.70, p = .043). Multivariate analysis identified several risk factors for death in adult PSC patients receiving LDLT including a male donor (HR = 2.49, p = .025). Adult PSC patients with LDLT versus DBD conferred increased mortality from disease recurrence (subdistribution hazard ratio [subHR] = 5.36, p = .001) and biliary complications (subHR = 4.40, p = .006) in multivariate analysis. While long-term outcome following LDLT for AILD is generally favorable, PSC patients with LDLT compared to DBD might be at increased risk of death.
1 Department of Medicine University Medical Center Hamburg Eppendorf Hamburg Germany
Avicenna Center for Medicine and Organ Transplant Shiraz University of Medical Sciences Shiraz Iran
Department of General Surgery Ege University Medical School Izmir Turkey
Department of General Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland
Department of Hepatobiliary and Digestive Surgery Pontchaillou University Hospital Rennes France
Department of Hepatology and Gastroenterology University Hospital of Henri Mondor Creteil France
Department of HPB Surgery Queen Elizabeth Hospital Birmingham UK
Department of Visceral and Transplant Surgery University Hospital Essen Essen Germany
European Reference Network for Hepatological Diseases Hamburg Germany
Hepato Biliary Center AP HP Paul Brousse Hospital University of Paris Sud Villejuif France
King's Liver Transplant Unit King's College Hospital NHS Foundation Trust London United Kingdom
Liver Transplantation Center Florence Nightingale Hospital Istanbul Turkey
Martin Zeitz Center for Rare Diseases University Medical Centre Hamburg Eppendorf Hamburg Germany
Organ Transplantation Center Memorial Hospital Istanbul Turkey
Citace poskytuje Crossref.org
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