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Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis
SB. Goodman, E. Gibon, J. Gallo, M. Takagi
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy
Grantová podpora
R01 AR063713
NIAMS NIH HHS - United States
AZV NU21-06-00370.
Ministerstvo Zdravotnictví Ceské Republiky
R01 AR073145
NIAMS NIH HHS - United States
- MeSH
- artroplastiky kloubů * MeSH
- lidé MeSH
- makrofágy MeSH
- osteolýza * MeSH
- protézy kloubů * MeSH
- selhání protézy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
PURPOSE OF REVIEW: Joint replacement has revolutionized the treatment of end-stage arthritis. We highlight the key role of macrophages in the innate immune system in helping to ensure that the prosthesis-host interface remains biologically robust. RECENT FINDINGS: Osteoimmunology is of great interest to researchers investigating the fundamental biological and material aspects of joint replacement. Constant communication between cells of the monocyte/macrophage/osteoclast lineage and the mesenchymal stem cell-osteoblast lineage determines whether a durable prosthesis-implant interface is obtained, or whether implant loosening occurs. Tissue and circulating monocytes/macrophages provide local surveillance of stimuli such as the presence of byproducts of wear and can quickly polarize to pro- and anti-inflammatory phenotypes to re-establish tissue homeostasis. When these mechanisms fail, periprosthetic osteolysis results in progressive bone loss and painful failure of mechanical fixation. Immune modulation of the periprosthetic microenvironment is a potential intervention to facilitate long-term durability of prosthetic interfaces.
Department of Orthopaedic Surgery Mayo Clinic Rochester MN USA
Department of Orthopaedic Surgery Yamagata University Faculty of Medicine Yamagata Japan
Departments of Orthopaedic Surgery and Bioengineering Stanford University Stanford CA USA
Citace poskytuje Crossref.org
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