• Je něco špatně v tomto záznamu ?

Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness in Autism Spectrum Disorders

DS. Dhanjal, S. Bhardwaj, C. Chopra, R. Singh, J. Patocka, B. Plucar, E. Nepovimova, M. Valis, K. Kuca

. 2022 ; 29 (15) : 2632-2651. [pub] -

Jazyk angličtina Země Spojené arabské emiráty

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019509

Grantová podpora
VT2019-2021 University Hospital Hradec Kralove, UHK PrF project
CZ.02.1.01/0.0/0.0/17_048/0007441 PERSONMED—Center for the Development of Personalized Medicine in Age-Related Diseases

Autism is a neurodevelopmental disorder belonging to the autism spectrum disorder (ASD). In ASDs, the individuals show substantial impairments in social communication, repetitive behaviours, and sensory behaviours deficits in the early stages of their life. Globally, the prevalence of autism is estimated to be less than 1%, especially in high- -income countries. In recent decades, there has been a drastic increase in the incidence of ASD, which has put ASD into the category of epidemics. Presently, two US Food and Drug Administration-approved drugs, aripiprazole and risperidone, are used to treat symptoms of agitation and irritability in autistic children. However, to date, no medication has been found to treat the core symptoms of ASD. The adverse side effects of conventional medicine and limited treatment options have led families of autistic children to turn to complementary and alternative medicine (CAM) treatments, which are perceived as relatively safe compared to conventional medicine. Recently N, N-dimethylglycine (DMG), a dietary supplement, has emerged as a useful supplement to improve the mental and physical state of children with ASD. The current review discusses ASD, the prevalence of ASD, the CAM approach, and the efficacy of CAM treatment in children with ASD. Moreover, it highlights the chemistry, pharmacological effect, and clinical studies of DMG, highlighting its potential for improving the lifestyle of children with ASD.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22019509
003      
CZ-PrNML
005      
20220804135723.0
007      
ta
008      
220720s2022 ts f 000 0|eng||
009      
AR
024    7_
$a 10.2174/0929867328666211125091811 $2 doi
035    __
$a (PubMed)34823458
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ts
100    1_
$a Dhanjal, Daljeet Singh $u Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India
245    10
$a Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness in Autism Spectrum Disorders / $c DS. Dhanjal, S. Bhardwaj, C. Chopra, R. Singh, J. Patocka, B. Plucar, E. Nepovimova, M. Valis, K. Kuca
520    9_
$a Autism is a neurodevelopmental disorder belonging to the autism spectrum disorder (ASD). In ASDs, the individuals show substantial impairments in social communication, repetitive behaviours, and sensory behaviours deficits in the early stages of their life. Globally, the prevalence of autism is estimated to be less than 1%, especially in high- -income countries. In recent decades, there has been a drastic increase in the incidence of ASD, which has put ASD into the category of epidemics. Presently, two US Food and Drug Administration-approved drugs, aripiprazole and risperidone, are used to treat symptoms of agitation and irritability in autistic children. However, to date, no medication has been found to treat the core symptoms of ASD. The adverse side effects of conventional medicine and limited treatment options have led families of autistic children to turn to complementary and alternative medicine (CAM) treatments, which are perceived as relatively safe compared to conventional medicine. Recently N, N-dimethylglycine (DMG), a dietary supplement, has emerged as a useful supplement to improve the mental and physical state of children with ASD. The current review discusses ASD, the prevalence of ASD, the CAM approach, and the efficacy of CAM treatment in children with ASD. Moreover, it highlights the chemistry, pharmacological effect, and clinical studies of DMG, highlighting its potential for improving the lifestyle of children with ASD.
650    12
$a poruchy autistického spektra $x farmakoterapie $x epidemiologie $7 D000067877
650    12
$a autistická porucha $7 D001321
650    _2
$a dítě $7 D002648
650    _2
$a lidé $7 D006801
650    _2
$a živiny $7 D000078622
650    _2
$a sarkosin $x analogy a deriváty $x terapeutické užití $7 D012521
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Bhardwaj, Sonali $u Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India
700    1_
$a Chopra, Chirag $u Department of Molecular Biology and Genetic Engineering, School of Bioengineering and Biosciences, Lovely Professional University, India
700    1_
$a Singh, Reena $u Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India
700    1_
$a Patocka, Jiri $u Department of Radiology, Toxicology and Populati on Protecti on, Faculty of Health and Social Studies, the University of South Bohemia in Ceske Budejovice, Czech Republic $u University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
700    1_
$a Plucar, Bohumir $u Reflex Therapy Laboratory, Udolni 393/18, 60200 Brno, Czech Republic
700    1_
$a Nepovimova, Eugenie $u Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
700    1_
$a Valis, Martin $u University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
700    1_
$a Kuca, Kamil $u University Hospital Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
773    0_
$w MED00001274 $t Current medicinal chemistry $x 1875-533X $g Roč. 29, č. 15 (2022), s. 2632-2651
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34823458 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804135717 $b ABA008
999    __
$a ok $b bmc $g 1822913 $s 1170752
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 29 $c 15 $d 2632-2651 $e - $i 1875-533X $m Current medicinal chemistry $n Curr Med Chem $x MED00001274
GRA    __
$a VT2019-2021 $p University Hospital Hradec Kralove, UHK PrF project
GRA    __
$a CZ.02.1.01/0.0/0.0/17_048/0007441 $p PERSONMED—Center for the Development of Personalized Medicine in Age-Related Diseases
LZP    __
$a Pubmed-20220720
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace