• Something wrong with this record ?

Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study

DT. Asuzu, A. Bunevicius, R. Kormath Anand, M. Suleiman, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdel Karim, AMN. El-Shehaby, RM. Emad Eldin, T. Chytka, R. Liščák, K. Sheehan, D. Sheehan, M. Perez Caceres, D. Mathieu, CC. Lee, HC. Yang, P....

. 2022 ; 136 (4) : 1070-1076. [pub] 20210924

Language English Country United States

Document type Journal Article, Multicenter Study

OBJECTIVE: Resection of meningiomas in direct contact with the anterior optic apparatus carries risk of injury to the visual pathway. Stereotactic radiosurgery (SRS) offers a minimally invasive alternative. However, its use is limited owing to the risk of radiation-induced optic neuropathy. Few SRS studies have specifically assessed the risks and benefits of treating meningiomas in direct contact with the optic nerve, chiasm, or optic tract. The authors hypothesized that SRS is safe for select patients with meningiomas in direct contact with the anterior optic apparatus. METHODS: The authors performed an international multicenter retrospective analysis of 328 patients across 11 institutions. All patients had meningiomas in direct contract with the optic apparatus. Patients were followed for a median duration of 56 months after SRS. Neurological examinations, including visual function evaluations, were performed at follow-up visits. Clinical and treatment variables were collected at each site according to protocol. Tumor volumes were assessed with serial MR imaging. Variables predictive of visual deficit were identified using univariable and multivariable logistic regression. RESULTS: SRS was the initial treatment modality for 64.6% of patients, and 93% of patients received SRS as a single fraction. Visual information was available for 302 patients. Of these patients, visual decline occurred in 29 patients (9.6%), of whom 12 (41.4%) had evidence of tumor progression. Visual decline in the remaining 17 patients (5.6%) was not associated with tumor progression. Pre-SRS Karnofsky Performance Status predicted visual decline in adjusted analysis (adjusted OR 0.9, 95% CI 0.9-1.0, p < 0.01). Follow-up imaging data were available for 322 patients. Of these patients, 294 patients (91.3%) had radiographic evidence of stability or tumor regression at last follow up. Symptom duration was associated with tumor progression in adjusted analysis (adjusted OR 1.01, adjusted 95% CI 1.0-1.02, adjusted p = 0.02). CONCLUSIONS: In this international multicenter study, the vast majority of patients exhibited tumor control and preservation of visual function when SRS was used to treat meningioma in direct contact with the anterior optic pathways. SRS is a relatively safe treatment modality for select patients with perioptic meningiomas in direct contact with the optic apparatus.

Centro Gamma Knife Dominicano and CEDIMAT Radiology Department Santo Domingo Dominican Republic

Clinical Oncology Department Ain Shams University Cairo Egypt

Department of Neurosurgery Humanitas Clinical and Research Center IRCCS Rozzano Italy

Department of Neurosurgery Neurological Institute Taipei Veterans General Hospital Taipei Taiwan

Department of Neurosurgery Université de Sherbrooke Centre de recherche du CHUS Sherbrooke Quebec Canada

Department of Neurosurgery University of Southern California Los Angeles California

Department of Neurosurgery University of Virginia Charlottesville Virginia

Department of Neurosurgery West Virginia University Morgantown West Virginia

Department of Radiation Oncology University of Colorado Aurora Colorado

Department of Radiation Oncology University of Southern California Los Angeles California

Department of Radiation Oncology West Virginia University Morgantown West Virginia

Division of Radiation Oncology Department of Oncology University of Alberta Edmonton Canada

Gamma Knife Center Cairo Nasser Institute Hospital Cairo Egypt

Gamma Knife Center Jewish Hospital Mayfield Clinic Cincinnati Ohio

Neurosurgery Department Ain Shams University Cairo Egypt

Neurosurgery Department Benha University Qalubya Egypt

Radiation Oncology Department National Cancer Institute Cairo University Egypt

School of Medicine National Yang Ming University Taipei Taiwan

Stereotactic and Radiation Neurosurgery Department Na Homolce Hospital Prague Czech Republic

Surgical Neurology Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22019666
003      
CZ-PrNML
005      
20251001115142.0
007      
ta
008      
220720s2022 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.3171/2021.3.JNS21328 $2 doi
035    __
$a (PubMed)34560648
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Asuzu, David T $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia $u Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
245    10
$a Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study / $c DT. Asuzu, A. Bunevicius, R. Kormath Anand, M. Suleiman, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdel Karim, AMN. El-Shehaby, RM. Emad Eldin, T. Chytka, R. Liščák, K. Sheehan, D. Sheehan, M. Perez Caceres, D. Mathieu, CC. Lee, HC. Yang, P. Picozzi, A. Franzini, L. Attuati, H. Speckter, J. Olivo, S. Patel, CP. Cifarelli, DT. Cifarelli, JD. Hack, BA. Strickland, G. Zada, EL. Chang, KR. Fakhoury, CG. Rusthoven, RE. Warnick, JP. Sheehan
520    9_
$a OBJECTIVE: Resection of meningiomas in direct contact with the anterior optic apparatus carries risk of injury to the visual pathway. Stereotactic radiosurgery (SRS) offers a minimally invasive alternative. However, its use is limited owing to the risk of radiation-induced optic neuropathy. Few SRS studies have specifically assessed the risks and benefits of treating meningiomas in direct contact with the optic nerve, chiasm, or optic tract. The authors hypothesized that SRS is safe for select patients with meningiomas in direct contact with the anterior optic apparatus. METHODS: The authors performed an international multicenter retrospective analysis of 328 patients across 11 institutions. All patients had meningiomas in direct contract with the optic apparatus. Patients were followed for a median duration of 56 months after SRS. Neurological examinations, including visual function evaluations, were performed at follow-up visits. Clinical and treatment variables were collected at each site according to protocol. Tumor volumes were assessed with serial MR imaging. Variables predictive of visual deficit were identified using univariable and multivariable logistic regression. RESULTS: SRS was the initial treatment modality for 64.6% of patients, and 93% of patients received SRS as a single fraction. Visual information was available for 302 patients. Of these patients, visual decline occurred in 29 patients (9.6%), of whom 12 (41.4%) had evidence of tumor progression. Visual decline in the remaining 17 patients (5.6%) was not associated with tumor progression. Pre-SRS Karnofsky Performance Status predicted visual decline in adjusted analysis (adjusted OR 0.9, 95% CI 0.9-1.0, p < 0.01). Follow-up imaging data were available for 322 patients. Of these patients, 294 patients (91.3%) had radiographic evidence of stability or tumor regression at last follow up. Symptom duration was associated with tumor progression in adjusted analysis (adjusted OR 1.01, adjusted 95% CI 1.0-1.02, adjusted p = 0.02). CONCLUSIONS: In this international multicenter study, the vast majority of patients exhibited tumor control and preservation of visual function when SRS was used to treat meningioma in direct contact with the anterior optic pathways. SRS is a relatively safe treatment modality for select patients with perioptic meningiomas in direct contact with the optic apparatus.
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    12
$a meningeální nádory $x diagnostické zobrazování $x radioterapie $x chirurgie $7 D008577
650    12
$a meningeom $x diagnostické zobrazování $x radioterapie $x chirurgie $7 D008579
650    12
$a radiochirurgie $x škodlivé účinky $x metody $7 D016634
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a výsledek terapie $7 D016896
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Bunevicius, Adomas $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia
700    1_
$a Kormath Anand, Rithika $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia
700    1_
$a Suleiman, Mohanad $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia
700    1_
$a Nabeel, Ahmed M $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Benha University, Qalubya, Egypt
700    1_
$a Reda, Wael A $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Ain Shams University, Cairo, Egypt
700    1_
$a Tawadros, Sameh R $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Ain Shams University, Cairo, Egypt
700    1_
$a Abdel Karim, Khaled $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Clinical Oncology Department, Ain Shams University, Cairo, Egypt
700    1_
$a El-Shehaby, Amr M N $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Ain Shams University, Cairo, Egypt
700    1_
$a Emad Eldin, Reem M $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Radiation Oncology Department, National Cancer Institute, Cairo University, Egypt
700    1_
$a Chytka, Tomáš $u Stereotactic and Radiation Neurosurgery Department, Na Homolce Hospital, Prague, Czech Republic $7 xx0335997
700    1_
$a Liščák, Roman $u Stereotactic and Radiation Neurosurgery Department, Na Homolce Hospital, Prague, Czech Republic
700    1_
$a Sheehan, Kimball $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia
700    1_
$a Sheehan, Darrah $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia
700    1_
$a Perez Caceres, Marco $u Department of Neurosurgery, Université de Sherbrooke, Centre de recherche du CHUS, Sherbrooke, Quebec, Canada
700    1_
$a Mathieu, David $u Department of Neurosurgery, Université de Sherbrooke, Centre de recherche du CHUS, Sherbrooke, Quebec, Canada
700    1_
$a Lee, Cheng-Chia $u Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan $u School of Medicine, National Yang-Ming University, Taipei, Taiwan
700    1_
$a Yang, Huai-Che $u Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan $u School of Medicine, National Yang-Ming University, Taipei, Taiwan
700    1_
$a Picozzi, Piero $u Department of Neurosurgery, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy
700    1_
$a Franzini, Andrea $u Department of Neurosurgery, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy
700    1_
$a Attuati, Luca $u Department of Neurosurgery, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy
700    1_
$a Speckter, Herwin $u Centro Gamma Knife Dominicano and CEDIMAT Radiology Department, Santo Domingo, Dominican Republic
700    1_
$a Olivo, Jeremy $u Centro Gamma Knife Dominicano and CEDIMAT Radiology Department, Santo Domingo, Dominican Republic
700    1_
$a Patel, Samir $u Division of Radiation Oncology, Department of Oncology, University of Alberta, Edmonton, Canada
700    1_
$a Cifarelli, Christopher P $u Department of Neurosurgery, West Virginia University, Morgantown, West Virginia $u Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia
700    1_
$a Cifarelli, Daniel T $u Department of Neurosurgery, West Virginia University, Morgantown, West Virginia
700    1_
$a Hack, Joshua D $u Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia
700    1_
$a Strickland, Ben A $u Department of Neurosurgery, University of Southern California, Los Angeles, California
700    1_
$a Zada, Gabriel $u Department of Neurosurgery, University of Southern California, Los Angeles, California
700    1_
$a Chang, Eric L $u Department of Radiation Oncology, University of Southern California, Los Angeles, California
700    1_
$a Fakhoury, Kareem R $u Department of Radiation Oncology, University of Colorado, Aurora, Colorado
700    1_
$a Rusthoven, Chad G $u Department of Radiation Oncology, University of Colorado, Aurora, Colorado
700    1_
$a Warnick, Ronald E $u Gamma Knife Center, Jewish Hospital, Mayfield Clinic, Cincinnati, Ohio; and
700    1_
$a Sheehan, Jason P $u Department of Neurosurgery, University of Virginia, Charlottesville, Virginia
773    0_
$w MED00002843 $t Journal of neurosurgery $x 1933-0693 $g Roč. 136, č. 4 (2022), s. 1070-1076
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34560648 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20251001115129 $b ABA008
999    __
$a ok $b bmc $g 1823039 $s 1170909
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 136 $c 4 $d 1070-1076 $e 20210924 $i 1933-0693 $m Journal of neurosurgery $n J Neurosurg $x MED00002843
LZP    __
$a Pubmed-20220720

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...