• Je něco špatně v tomto záznamu ?

Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters

O. Van Hoey, L. Stolarczyk, J. Lillhök, L. Eliasson, N. Mojzeszek, M. Liszka, A. Alkhiat, V. Mares, F. Trompier, S. Trinkl, I. Martínez-Rovira, M. Romero-Expósito, C. Domingo, O. Ploc, R. Harrison, P. Olko

. 2022 ; 12 (-) : 903537. [pub] 20220908

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22023344

Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22023344
003      
CZ-PrNML
005      
20221031095249.0
007      
ta
008      
221010s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fonc.2022.903537 $2 doi
035    __
$a (PubMed)36158693
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Van Hoey, Olivier $u Belgian Nuclear Research Center (SCK CEN), Institute for Environment, Health and Safety (EHS), Mol, Belgium
245    10
$a Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters / $c O. Van Hoey, L. Stolarczyk, J. Lillhök, L. Eliasson, N. Mojzeszek, M. Liszka, A. Alkhiat, V. Mares, F. Trompier, S. Trinkl, I. Martínez-Rovira, M. Romero-Expósito, C. Domingo, O. Ploc, R. Harrison, P. Olko
520    9_
$a Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Stolarczyk, Liliana $u Danish Centre for Particle Therapy, Aarhus University Hospital (AUH), Aarhus, Denmark $u Institute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, Poland $u The Skandion Clinic, Uppsala, Sweden
700    1_
$a Lillhök, Jan $u Swedish Radiation Safety Authority, Solna, Sweden
700    1_
$a Eliasson, Linda $u Department of Physics, Royal Institute of Technology (KTH), Stockholm, Sweden
700    1_
$a Mojzeszek, Natalia $u Institute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, Poland
700    1_
$a Liszka, Malgorzata $u Institute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, Poland $u The Skandion Clinic, Uppsala, Sweden
700    1_
$a Alkhiat, Ali $u The Skandion Clinic, Uppsala, Sweden $u Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
700    1_
$a Mares, Vladimir $u Helmholtz Zentrum München, Institute of Radiation Medicine, Neuherberg, Germany
700    1_
$a Trompier, François $u Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France
700    1_
$a Trinkl, Sebastian $u Helmholtz Zentrum München, Institute of Radiation Medicine, Neuherberg, Germany $u Federal Office for Radiation Protection, Neuherberg, Germany
700    1_
$a Martínez-Rovira, Immaculada $u Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, Spain
700    1_
$a Romero-Expósito, Maite $u Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, Spain
700    1_
$a Domingo, Carles $u Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, Spain
700    1_
$a Ploc, Ondrej $u Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences (CAS), Prague, Czechia
700    1_
$a Harrison, Roger $u Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle Upon Tyne, United Kingdom
700    1_
$a Olko, Pawel $u Institute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, Poland
773    0_
$w MED00182989 $t Frontiers in oncology $x 2234-943X $g Roč. 12, č. - (2022), s. 903537
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36158693 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20221010 $b ABA008
991    __
$a 20221031095247 $b ABA008
999    __
$a ind $b bmc $g 1853822 $s 1174632
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 12 $c - $d 903537 $e 20220908 $i 2234-943X $m Frontiers in oncology $n Front Oncol $x MED00182989
LZP    __
$a Pubmed-20221010

Najít záznam

Citační ukazatele

Možnosti archivace