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Nationwide observational study of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic

J. David, V. Stara, O. Hradsky, J. Tuckova, K. Slaba, P. Jabandziev, L. Sasek, M. Huml, I. Zidkova, J. Pavlicek, A. Palatova, E. Klaskova, K. Banszka, E. Terifajova, R. Vyhnanek, M. Bloomfield, S. Fingerhutova, P. Dolezalova, L. Prochazkova, G....

. 2022 ; 181 (10) : 3663-3672. [pub] 20220820

Language English Country Germany

Document type Journal Article, Observational Study

Persistent link   https://www.medvik.cz/link/bmc22024271
E-resources Online Full text

NLK ProQuest Central from 1996-01-01 to 1 year ago
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Medline Complete (EBSCOhost) from 1997-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest) from 1996-01-01 to 1 year ago
Health & Medicine (ProQuest) from 1996-01-01 to 1 year ago
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Public Health Database (ProQuest) from 1996-01-01 to 1 year ago

Links

PubMed 35987943
DOI 10.1007/s00431-022-04593-7
Knihovny.cz E-resources

The worldwide outbreak of the novel 2019 coronavirus disease (COVID-19) has led to recognition of a new immunopathological condition: paediatric inflammatory multisystem syndrome (PIMS-TS). The Czech Republic (CZ) suffered from one of the highest incidences of individuals who tested positive during pandemic waves. The aim of this study was to analyse epidemiological, clinical, and laboratory characteristics of all cases of paediatric inflammatory multisystem syndrome (PIMS-TS) in the Czech Republic (CZ) and their predictors of severe course. We performed a retrospective-prospective nationwide observational study based on patients hospitalised with PIMS-TS in CZ between 1 November 2020 and 31 May 2021. The anonymised data of patients were abstracted from medical record review. Using the inclusion criteria according to World Health Organization definition, 207 patients with PIMS-TS were enrolled in this study. The incidence of PIMS-TS out of all SARS-CoV-2-positive children was 0.9:1,000. The estimated delay between the occurrence of PIMS-TS and the COVID-19 pandemic wave was 3 weeks. The significant initial predictors of myocardial dysfunction included mainly cardiovascular signs (hypotension, oedema, oliguria/anuria, and prolonged capillary refill). During follow-up, most patients (98.8%) had normal cardiac function, with no residual findings. No fatal cases were reported.Conclusions: A 3-week interval in combination with incidence of COVID-19 could help increase pre-test probability of PIMS-TS during pandemic waves in the suspected cases. Although the parameters of the models do not allow one to completely divide patients into high and low risk groups, knowing the most important predictors surely could help clinical management.

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$a The worldwide outbreak of the novel 2019 coronavirus disease (COVID-19) has led to recognition of a new immunopathological condition: paediatric inflammatory multisystem syndrome (PIMS-TS). The Czech Republic (CZ) suffered from one of the highest incidences of individuals who tested positive during pandemic waves. The aim of this study was to analyse epidemiological, clinical, and laboratory characteristics of all cases of paediatric inflammatory multisystem syndrome (PIMS-TS) in the Czech Republic (CZ) and their predictors of severe course. We performed a retrospective-prospective nationwide observational study based on patients hospitalised with PIMS-TS in CZ between 1 November 2020 and 31 May 2021. The anonymised data of patients were abstracted from medical record review. Using the inclusion criteria according to World Health Organization definition, 207 patients with PIMS-TS were enrolled in this study. The incidence of PIMS-TS out of all SARS-CoV-2-positive children was 0.9:1,000. The estimated delay between the occurrence of PIMS-TS and the COVID-19 pandemic wave was 3 weeks. The significant initial predictors of myocardial dysfunction included mainly cardiovascular signs (hypotension, oedema, oliguria/anuria, and prolonged capillary refill). During follow-up, most patients (98.8%) had normal cardiac function, with no residual findings. No fatal cases were reported.Conclusions: A 3-week interval in combination with incidence of COVID-19 could help increase pre-test probability of PIMS-TS during pandemic waves in the suspected cases. Although the parameters of the models do not allow one to completely divide patients into high and low risk groups, knowing the most important predictors surely could help clinical management.
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$a Stara, Veronika $u Department of Paediatrics, Second Faculty of Medicine, Charles University and University Hospital Motol, V Úvalu 84, 150 06, Prague, Czech Republic
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$a Hradsky, Ondrej $u Department of Paediatrics, Second Faculty of Medicine, Charles University and University Hospital Motol, V Úvalu 84, 150 06, Prague, Czech Republic
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$a Huml, Michal $u Department of Paediatrics, Faculty of Medicine, Charles University and University Hospital Plzeň, Plzeň, Czech Republic
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$a Zidkova, Iveta $u Department of Paediatrics, Faculty of Medicine, University of Ostrava and University Hospital Ostrava, Ostrava, Czech Republic
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$a Palatova, Alzbeta $u Department of Paediatrics, Faculty of Medicine, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic
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$a Klaskova, Eva $u Department of Paediatrics, Faculty of Medicine, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic
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$a Banszka, Karina $u Department of Paediatrics, Faculty of Medicine, Charles University and University Hospital Hradec Králové, Hradec Králové, Czech Republic
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$a Terifajova, Eva $u Department of Paediatrics, Faculty of Medicine, Charles University and University Hospital Hradec Králové, Hradec Králové, Czech Republic
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$a Vyhnanek, Radim $u Department of Paediatrics, First Faculty of Medicine, Charles University and University Thomayer Hospital, Prague, Czech Republic
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$a Fingerhutova, Sarka $u Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
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$a Dolezalova, Pavla $u Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
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$a Prochazkova, Lucie $u Department of Paediatrics, Regional Bata Hospital, Zlín, Czech Republic
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$a Chramostova, Gabriela $u Department of Paediatrics, Regional Hospital, Kolín, Czech Republic
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$a Fencl, Filip $u Department of Paediatrics, Second Faculty of Medicine, Charles University and University Hospital Motol, V Úvalu 84, 150 06, Prague, Czech Republic
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