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Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV)
L. Borradori, N. Van Beek, C. Feliciani, B. Tedbirt, E. Antiga, R. Bergman, BC. Böckle, M. Caproni, F. Caux, NS. Chandran, G. Cianchini, M. Daneshpazhooh, D. De, D. Didona, GM. Di Zenzo, M. Dmochowski, K. Drenovska, J. Ehrchen, M. Goebeler, R....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
PubMed
35766904
DOI
10.1111/jdv.18220
Knihovny.cz E-zdroje
- MeSH
- bulózní pemfigoid * diagnóza farmakoterapie MeSH
- dermatologie * MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- kvalita života MeSH
- lidé MeSH
- puchýř farmakoterapie MeSH
- senioři MeSH
- venerologie * MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, generalized bullous lesions. A subset of patients only develops excoriations, prurigo-like lesions, and eczematous and/or urticarial erythematous lesions. The disease, which is significantly associated with neurological disorders, has high morbidity and severely impacts the quality of life. OBJECTIVES AND METHODOLOGY: The Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology sought to update the guidelines for the management of BP based on new clinical information, and new evidence on diagnostic tools and interventions. The recommendations are either evidence-based or rely on expert opinion. The degree of consent among all task force members was included. RESULTS: Treatment depends on the severity of BP and patients' comorbidities. High-potency topical corticosteroids are recommended as the mainstay of treatment whenever possible. Oral prednisone at a dose of 0.5 mg/kg/day is a recommended alternative. In case of contraindications or resistance to corticosteroids, immunosuppressive therapies, such as methotrexate, azathioprine, mycophenolate mofetil or mycophenolate acid, may be recommended. The use of doxycycline and dapsone is controversial. They may be recommended, in particular, in patients with contraindications to oral corticosteroids. B-cell-depleting therapy and intravenous immunoglobulins may be considered in treatment-resistant cases. Omalizumab and dupilumab have recently shown promising results. The final version of the guideline was consented to by several patient organizations. CONCLUSIONS: The guidelines for the management of BP were updated. They summarize evidence- and expert-based recommendations useful in clinical practice.
Center for Research on Inflammation of the Skin University of Lübeck Lübeck Germany
Department Dermatology and Immunodermatology Medical University of Warsaw Warsaw Poland
Department of Dermatology Aarhus University Hospital Aarhus Denmark
Department of Dermatology and Allergology Ludwig Maximilian University Munich Germany
Department of Dermatology and Allergology Philipps University Marburg Germany
Department of Dermatology and Venereology Akdeniz University Faculty of Medicine Antalya Turkey
Department of Dermatology Hospital Clínic de Barcelona Universitat de Barcelona Barcelona Spain
Department of Dermatology Inselspital Bern University Hospital Bern Switzerland
Department of Dermatology Medical University of Sofia Sofia Bulgaria
Department of Dermatology Medical University Sofia Bulgaria
Department of Dermatology Ospedale Classificato Cristo Re Rome Italy
Department of Dermatology Rambam Health Care Campus Haifa Israel
Department of Dermatology School of Medicine Koç University Istanbul Turkey
Department of Dermatology University of Lübeck Lübeck Germany
Department of Dermatology University of Münster Münster Germany
Department of Dermatology Venereology and Allergology Innsbruck Medical University Innsbruck Austria
Department of Dermatology Venereology and Allergology University Hospital Würzburg Würzburg Germany
Department of Dermatology Venereology and Dermatooncology Semmelweis University Budapest Hungary
Department of Dermatology Xijing Hospital 4th Military Medical University Xi'an China
Department of Dermatovenereology Masaryk University University Hospital St Anna Brno
Department of Dermatovenereology University Hospital Brno Brno Czech Republic
Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore
Department of Pathophysiology and Transplantation Università degli Studi di Milano Milan Italy
Dermatology Unit Department of Medicine and Surgery University Hospital University of Parma Italy
Dermatology Unit Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan Italy
DermoLab Institute of Dermatology University of Modena and Reggio Emilia Modena Italy
Division of Genetics and Molecular Medicine King's College London Guy's Hospital London UK
Genetics and Rare Diseases Research Division Bambino Gesù Children's Hospital IRCCS Rome Italy
Laboratory of Molecular and Cell Biology Istituto Dermopatico dell'Immacolata IDI IRCCS Rome Italy
Lübeck Institute of Experimental Dermatology University of Lübeck Lübeck Germany
Medical Faculty The Sigmund Freud Private University Vienna Austria
National Skin Centre Singapore Singapore
Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel
Section of Dermatology Department of Health Sciences University of Florence Florence Italy
St John's Institute of Dermatology Viapath Analytics LLP St Thomas' Hospital London UK
Citace poskytuje Crossref.org
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- $a Borradori, L $u Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland $1 https://orcid.org/https://orcid.org/0000000304246297
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- $a BACKGROUND: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, generalized bullous lesions. A subset of patients only develops excoriations, prurigo-like lesions, and eczematous and/or urticarial erythematous lesions. The disease, which is significantly associated with neurological disorders, has high morbidity and severely impacts the quality of life. OBJECTIVES AND METHODOLOGY: The Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology sought to update the guidelines for the management of BP based on new clinical information, and new evidence on diagnostic tools and interventions. The recommendations are either evidence-based or rely on expert opinion. The degree of consent among all task force members was included. RESULTS: Treatment depends on the severity of BP and patients' comorbidities. High-potency topical corticosteroids are recommended as the mainstay of treatment whenever possible. Oral prednisone at a dose of 0.5 mg/kg/day is a recommended alternative. In case of contraindications or resistance to corticosteroids, immunosuppressive therapies, such as methotrexate, azathioprine, mycophenolate mofetil or mycophenolate acid, may be recommended. The use of doxycycline and dapsone is controversial. They may be recommended, in particular, in patients with contraindications to oral corticosteroids. B-cell-depleting therapy and intravenous immunoglobulins may be considered in treatment-resistant cases. Omalizumab and dupilumab have recently shown promising results. The final version of the guideline was consented to by several patient organizations. CONCLUSIONS: The guidelines for the management of BP were updated. They summarize evidence- and expert-based recommendations useful in clinical practice.
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