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Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air® real-world data
B. Sousa-Pinto, A. Sá-Sousa, RJ. Vieira, R. Amaral, L. Klimek, W. Czarlewski, JM. Antó, O. Pfaar, A. Bedbrook, V. Kvedariene, MT. Ventura, IJ. Ansotegui, KC. Bergmann, L. Brussino, GW. Canonica, V. Cardona, P. Carreiro-Martins, T. Casale, L....
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články
Grantová podpora
MASK
PubMed
35258105
DOI
10.1111/all.15275
Knihovny.cz E-zdroje
- MeSH
- alergická rýma * farmakoterapie epidemiologie MeSH
- antihistaminika terapeutické užití MeSH
- lidé MeSH
- rýma * farmakoterapie MeSH
- zvyky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
BACKGROUND: Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. METHODS: We analysed 2015-2020 MASK-air® European data. We compared days under no medication, monotherapy and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ('VAS Global Symptoms') and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within 1 year. RESULTS: We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy and 38,315 (17.3%) under co-medication. The median 'VAS Global Symptoms' was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p < .001). Medication use peaked during the spring, with similar patterns across different European regions (defined geographically or by Google Trends). Oral H1 -antihistamines were the most common medication in single and co-medication. Each patient reported using an annual average of 2.7 drugs, with 80% reporting two or more. CONCLUSIONS: Allergic rhinitis medication patterns are similar across European regions. One third of treatment days involved co-medication. These findings suggest that patients treat themselves according to their symptoms (irrespective of how they understand AR) and that co-medication use is driven by symptom severity.
Allergy Center CUF Descobertas Hospital Lisbon Portugal
Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece
Center for Rhinology and Allergology Wiesbaden Germany
CIBER Epidemiología y Salud Pública Barcelona Spain
CINTESIS Center for Health Technology and Services Research University of Porto Porto Portugal
Department of Allergy and Immunology Hospital Quironsalud Bizkaia Bilbao Spain
Department of Biomedical Sciences Humanitas University Pieve Emanuele Italy
Department of Clinical Immunology ALL MED Medical Research Institute Wrocław Poland
Department of Clinical Immunology Wrocław Medical University Wroclaw Poland
Department of Immunoallergology Cova da Beira University Hospital Centre Covilhã Portugal
Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton Ontario Canada
Department of Otolaryngology Head and Neck Surgery Universitätsmedizin Mainz Mainz Germany
Department of Otorhinolaryngology Chiba University Hospital Chiba Japan
Department of Otorhinolaryngology Head and Neck Surgery Semmelweis University Budapest Hungary
Department of Pulmonary medicine and tuberculosis University Hospital Brno Brno Czech Republic
Department of Pulmonary Medicine CHU Sart Tilman and GIGA I3 Research Group Liege Belgium
Department of Pulmonology Celal Bayar University Manisa Turkey
Division of Allergy Immunology University of South Florida Tampa Florida USA
Ecole Polytechnique Palaiseau IRBA Bretigny France
EFA European Federation of Allergy and Airways Diseases Patients' Associations Brussels Belgium
Eskisehir Osmangazi University Medical Faculty ENT Department Eskisehir Turkey
Faculty of Health Sciences University of Beira Interior Covilha Portugal
Fundaçao ProAR Federal University of Bahia and GARD WHO Planning Group Salvador Brazil
Fundacion Jimenez Diaz CIBERES Faculty of Medicine Autonoma University of Madrid Madrid Spain
IMSB Medical Faculty University of Cologne and ClinCompetence Cologne GmbH Cologne Germany
ISGlobal Barcelona Institute for Global Health Barcelona Spain
KYomed INNOV Montpellier France
Medical Consulting Czarlewski Levallois France
NOVA Medical School Comprehensive Health Research Center Lisbon Portugal
Nova Southeastern University Fort Lauderdale Florida USA
Personalized Medicine Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano Italy
Poltava State Medical University Poltava Ukraine
School of Medicine University CEU San Pablo Madrid Spain
Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina
Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland
Skin and Allergy Hospital Helsinki University Hospital University of Helsinki Helsinki Finland
SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy
UBIAir Clinical and Experimental Lung Centre University of Beira Interior Covilha Portugal
Universitat Pompeu Fabra Barcelona Spain
University Hospital Montpellier Montpellier France
University of Bari Medical School Unit of Geriatric Immunoallergology Bari Italy
Citace poskytuje Crossref.org
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- $a BACKGROUND: Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. METHODS: We analysed 2015-2020 MASK-air® European data. We compared days under no medication, monotherapy and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ('VAS Global Symptoms') and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within 1 year. RESULTS: We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy and 38,315 (17.3%) under co-medication. The median 'VAS Global Symptoms' was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p < .001). Medication use peaked during the spring, with similar patterns across different European regions (defined geographically or by Google Trends). Oral H1 -antihistamines were the most common medication in single and co-medication. Each patient reported using an annual average of 2.7 drugs, with 80% reporting two or more. CONCLUSIONS: Allergic rhinitis medication patterns are similar across European regions. One third of treatment days involved co-medication. These findings suggest that patients treat themselves according to their symptoms (irrespective of how they understand AR) and that co-medication use is driven by symptom severity.
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