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Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID-19
M. Sokolowska, GE. Rovati, Z. Diamant, E. Untersmayr, J. Schwarze, Z. Lukasik, F. Sava, A. Angelina, O. Palomares, CA. Akdis, L. O'Mahony, M. Jesenak, O. Pfaar, MJ. Torres, M. Sanak, SE. Dahlén, G. Woszczek
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
G1000758
Medical Research Council - United Kingdom
MC_PC_15031
Medical Research Council - United Kingdom
PubMed
35174512
DOI
10.1111/all.15258
Knihovny.cz E-zdroje
- MeSH
- alergie * farmakoterapie MeSH
- antiflogistika nesteroidní farmakologie terapeutické užití MeSH
- antivirové látky farmakologie terapeutické užití MeSH
- bronchiální astma * farmakoterapie MeSH
- COVID-19 * MeSH
- farmakoterapie COVID-19 MeSH
- ikosanoidy metabolismus MeSH
- konsensus MeSH
- lidé MeSH
- SARS-CoV-2 MeSH
- zánět farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Non-steroidal anti-inflammatory drugs (NSAIDs) and other eicosanoid pathway modifiers are among the most ubiquitously used medications in the general population. Their broad anti-inflammatory, antipyretic, and analgesic effects are applied against symptoms of respiratory infections, including SARS-CoV-2, as well as in other acute and chronic inflammatory diseases that often coexist with allergy and asthma. However, the current pandemic of COVID-19 also revealed the gaps in our understanding of their mechanism of action, selectivity, and interactions not only during viral infections and inflammation, but also in asthma exacerbations, uncontrolled allergic inflammation, and NSAIDs-exacerbated respiratory disease (NERD). In this context, the consensus report summarizes currently available knowledge, novel discoveries, and controversies regarding the use of NSAIDs in COVID-19, and the role of NSAIDs in asthma and viral asthma exacerbations. We also describe here novel mechanisms of action of leukotriene receptor antagonists (LTRAs), outline how to predict responses to LTRA therapy and discuss a potential role of LTRA therapy in COVID-19 treatment. Moreover, we discuss interactions of novel T2 biologicals and other eicosanoid pathway modifiers on the horizon, such as prostaglandin D2 antagonists and cannabinoids, with eicosanoid pathways, in context of viral infections and exacerbations of asthma and allergic diseases. Finally, we identify and summarize the major knowledge gaps and unmet needs in current eicosanoid research.
Allergy Unit Málaga Regional University Hospital IBIMA UMA Málaga Spain
Child Life and Health and Centre for Inflammation Research The University of Edinburgh Edinburgh UK
Christine Kühne Center for Allergy Research and Education Davos Switzerland
Department of Medicine Jagiellonian University Medical College Krakow Poland
Department of Respiratory Medicine and Allergology Skane University Hospital Lund Sweden
Departments of Medicine and Microbiology APC Microbiome Ireland University College Cork Cork Ireland
Swiss Institute of Allergy and Asthma Research University of Zurich Davos Switzerland
VIB Center for Inflammation Research Ghent University Ghent Belgium
Citace poskytuje Crossref.org
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