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The immune response to COVID-19: Does sex matter

JQ. Ho, MR. Sepand, B. Bigdelou, T. Shekarian, R. Esfandyarpour, P. Chauhan, V. Serpooshan, LK. Beura, G. Hutter, S. Zanganeh

. 2022 ; 166 (4) : 429-443. [pub] 20220503

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22025035
E-zdroje Online Plný text

NLK Free Medical Journals od 1958 do Před 1 rokem
Medline Complete (EBSCOhost) od 1958-01-01 do Před 1 rokem
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Odkazy

PubMed 35470422
DOI 10.1111/imm.13487
Knihovny.cz E-zdroje

The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has a complex interaction with the immune system, including growing evidence of sex-specific differences in the immune response. Sex-disaggregated analyses of epidemiological data indicate that males experience more severe symptoms and suffer higher mortality from COVID-19 than females. Many behavioural risk factors and biological factors may contribute to the different immune response. This review examines the immune response to SARS-CoV-2 infection in the context of sex, with emphasis on potential biological mechanisms explaining differences in clinical outcomes. Understanding sex differences in the pathophysiology of SARS-CoV-2 infection will help promote the development of specific strategies to manage the disease.

Citace poskytuje Crossref.org

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$a Sepand, Mohammad Reza $u Department of Bioengineering, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, USA
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$a Bigdelou, Banafsheh $u Department of Bioengineering, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, USA
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$a Shekarian, Tala $u Department of Neurosurgery, University Hospital Basel, Basel, Switzerland
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$a Serpooshan, Vahid $u Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, Georgia, USA
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$a Beura, Lalit K $u Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA
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