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Furcellaran Surface Deposition and Its Potential in Biomedical Applications
K. Štěpánková, K. Ozaltin, J. Pelková, H. Pištěková, I. Karakurt, S. Káčerová, M. Lehocky, P. Humpolicek, A. Vesel, M. Mozetic
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Free Medical Journals od 2000
Freely Accessible Science Journals od 2000
PubMed Central od 2007
Europe PubMed Central od 2007
ProQuest Central od 2000-03-01
Open Access Digital Library od 2000-01-01
Open Access Digital Library od 2007-01-01
Health & Medicine (ProQuest) od 2000-03-01
ROAD: Directory of Open Access Scholarly Resources od 2000
Odkazy
PubMed
35806443
DOI
10.3390/ijms23137439
Knihovny.cz E-zdroje
- MeSH
- algináty * MeSH
- antibakteriální látky farmakologie MeSH
- polyethylentereftaláty * chemie MeSH
- polymery chemie MeSH
- povrchové vlastnosti MeSH
- rostlinné gumy MeSH
- Publikační typ
- časopisecké články MeSH
Surface coatings of materials by polysaccharide polymers are an acknowledged strategy to modulate interfacial biocompatibility. Polysaccharides from various algal species represent an attractive source of structurally diverse compounds that have found application in the biomedical field. Furcellaran obtained from the red algae Furcellaria lumbricalis is a potential candidate for biomedical applications due to its gelation properties and mechanical strength. In the present study, immobilization of furcellaran onto polyethylene terephthalate surfaces by a multistep approach was studied. In this approach, N-allylmethylamine was grafted onto a functionalized polyethylene terephthalate (PET) surface via air plasma treatment. Furcellaran, as a bioactive agent, was anchored on such substrates. Surface characteristics were measured by means of contact angle measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Subsequently, samples were subjected to selected cell interaction assays, such as antibacterial activity, anticoagulant activity, fibroblasts and stem cell cytocompatibility, to investigate the Furcellaran potential in biomedical applications. Based on these results, furcellaran-coated PET films showed significantly improved embryonic stem cell (ESC) proliferation compared to the initial untreated material.
Department of Surface Engineering Jozef Stefan Institute Jamova cesta 39 1000 Ljubljana Slovenia
Faculty of Humanities Tomas Bata University in Zlín Stefanikova 5670 76001 Zlin Czech Republic
Faculty of Technology Tomas Bata University in Zlín Vavreckova 5669 76001 Zlin Czech Republic
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