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Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study
BJ. Coombes, V. Millischer, A. Batzler, B. Larrabee, L. Hou, S. Papiol, U. Heilbronner, M. Adli, K. Akiyama, N. Akula, AT. Amare, R. Ardau, B. Arias, JM. Aubry, L. Backlund, M. Bauer, BT. Baune, F. Bellivier, A. Benabarre, S. Bengesser, AK....
Status not-indexed Language English Country Switzerland
Document type Journal Article
PubMed
36408127
DOI
10.1159/000519707
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
Bipolar Center Wiener Neustadt Sigmund Freud University Medical Faculty Vienna Austria
Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden
Centre for Human Genetics University of Marburg Marburg Germany
Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos 3 Madrid Spain
Centro de Investigación Biomédica en Salud Mental Madrid Spain
Department for Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Biomedical Sciences University of Cagliari Cagliari Italy
Department of Clinical Neurosciences Karolinska Institutet Stockholm Sweden
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA
Department of Molecular Medicine and Surgery Karolinska Institute Stockholm Sweden
Department of Pharmacology Dalhousie University Halifax Nova Scotia Canada
Department of Psychiatry and Behavioral Sciences Johns Hopkins University Baltimore Maryland USA
Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA
Department of Psychiatry and Psychotherapy Ludwig Maximilian University Munich Munich Germany
Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria
Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada
Department of Psychiatry Dokkyo Medical University School of Medicine Mibu Japan
Department of Psychiatry Hokkaido University Graduate School of Medicine Sapporo Japan
Department of Psychiatry Lindner Center of Hope University of Cincinnati Mason Ohio USA
Department of Psychiatry Mood Disorders Unit HUG Geneva University Hospitals Geneva Switzerland
Department of Psychiatry Osaka University Graduate School of Medicine Osaka Japan
Department of Psychiatry University of California San Diego La Jolla California USA
Department of Psychiatry University of Campania Luigi Vanvitelli Naples Italy
Department of Psychiatry University of Münster Münster Germany
Department of Psychiatry University of Perugia Perugia Italy
Department of Psychiatry VA San Diego Healthcare System San Diego California USA
Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA
Douglas Mental Health University Institute McGill University Montreal Québec Canada
Fondation FondaMental Créteil France
Human Genomics Research Group Department of Biomedicine University Hospital Basel Basel Switzerland
Institut de Biomedicina de la Universitat de Barcelona Barcelona Spain
Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland
Institute of Neuroscience and Medicine Research Center Jülich Jülich Germany
Institute of Psychiatric Phenomics and Genomics University Hospital Munich Germany
Mental Health Research Group IMIM Hospital del Mar Barcelona Spain
Montreal Neurological Institute and Hospital McGill University Montreal Québec Canada
Mood Disorders Center of Ottawa Ottawa Ontario Canada
National Institute of Mental Health Klecany Czechia
Neuroscience Research Australia Sydney New South Wales Australia
Northern Adelaide Local Health Network Mental Health Services Adelaide South Australia Australia
Office of Mental Health VA San Diego Healthcare System San Diego California USA
Psychiatric Genetic Unit Poznan University of Medical Sciences Poznan Poland
School of Medical Sciences University of New South Wales Sydney New South Wales Australia
School of Psychiatry University of New South Wales Sydney New South Wales Australia
Service de Psychiatrie Hôpital Charles Perrens Bordeaux France
The Neuromodulation Unit McGill University Health Centre Montreal Québec Canada
Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy
Unitat de Zoologia i Antropologia Biològica University of Barcelona CIBERSAM Barcelona Spain
References provided by Crossref.org
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- $a 2021 $b 7 $c 3-4 $d 80-89 $e 20211118 $i 2673-298X (online) $m Complex psychiatry $n Complex Psychiatry $x MED00210145
- LZP __
- $a Pubmed-20230119
