• Je něco špatně v tomto záznamu ?

Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells

F. Lirussi, K. Pyrshev, S. Yesylevskyy, T. Rivel, T. Lopez, E. Coppens, S. Mura, P. Couvreur, C. Ramseyer

. 2023 ; 1869 (2) : 166614. [pub] 20221207

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22031960

Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22031960
003      
CZ-PrNML
005      
20230216100332.0
007      
ta
008      
230120s2023 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.bbadis.2022.166614 $2 doi
035    __
$a (PubMed)36494037
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Lirussi, Frédéric $u UMR 1231, Lipides Nutrition Cancer, INSERM, F-21000 Dijon, France; UFR des Sciences de Santé, Université Bourgogne Franche-Comté, F-25000 Besançon, France; Plateforme PACE, Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalo-Universitaire Besançon, F-25000 Besançon, France. Electronic address: frederic.lirussi@u-bourgogne.fr
245    10
$a Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells / $c F. Lirussi, K. Pyrshev, S. Yesylevskyy, T. Rivel, T. Lopez, E. Coppens, S. Mura, P. Couvreur, C. Ramseyer
520    9_
$a Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue.
650    _7
$a gemcitabin $7 D000093542 $2 czmesh
650    _2
$a lipidové dvojvrstvy $x metabolismus $7 D008051
650    _2
$a skvalen $x metabolismus $7 D013185
650    _2
$a buněčná membrána $x metabolismus $7 D002462
650    12
$a prekurzory léčiv $7 D011355
650    12
$a nádory $x metabolismus $7 D009369
655    _2
$a časopisecké články $7 D016428
700    1_
$a Pyrshev, Kyrylo $u UFR des Sciences de Santé, Université Bourgogne Franche-Comté, F-25000 Besançon, France; Department of Physics of Biological Systems, Institute of Physics of the National Academy of Sciences of Ukraine, 46 Nauky ave, 03028 Kyiv, Ukraine; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA; Department of Neurochemistry, Palladin Institute of Biochemistry of the NAS of Ukraine, 9 Leontovycha str., 01601 Kyiv, Ukraine
700    1_
$a Yesylevskyy, Semen $u Department of Physics of Biological Systems, Institute of Physics of the National Academy of Sciences of Ukraine, 46 Nauky ave, 03028 Kyiv, Ukraine; Laboratoire Chrono Environnement UMR CNRS 6249, Université de Bourgogne Franche-Comté, 16 route de Gray, 25030 Besançon Cedex, France; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, CZ-166 10, Prague 6, Czech Republic; Receptor.AI Inc, 20-22 Wenlock Road, London N1 7GU, United Kingdom
700    1_
$a Rivel, Timothée $u Laboratoire Chrono Environnement UMR CNRS 6249, Université de Bourgogne Franche-Comté, 16 route de Gray, 25030 Besançon Cedex, France; CEITEC - Central European Institute of Technology, Masaryk University, Kamenice, CZ-62500, Brno, Czech Republic
700    1_
$a Lopez, Tatiana $u UMR 1231, Lipides Nutrition Cancer, INSERM, F-21000 Dijon, France; UFR des Sciences de Santé, Université Bourgogne Franche-Comté, F-25000 Besançon, France
700    1_
$a Coppens, Eleonore $u Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296, Châtenay-Malabry, France
700    1_
$a Mura, Simona $u Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296, Châtenay-Malabry, France
700    1_
$a Couvreur, Patrick $u Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296, Châtenay-Malabry, France
700    1_
$a Ramseyer, Christophe $u Laboratoire Chrono Environnement UMR CNRS 6249, Université de Bourgogne Franche-Comté, 16 route de Gray, 25030 Besançon Cedex, France
773    0_
$w MED00000539 $t Biochimica et biophysica acta. Molecular basis of disease $x 1879-260X $g Roč. 1869, č. 2 (2023), s. 166614
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36494037 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230216100326 $b ABA008
999    __
$a ok $b bmc $g 1891015 $s 1183295
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 1869 $c 2 $d 166614 $e 20221207 $i 1879-260X $m Biochimica et biophysica acta. Molecular basis of disease $n Biochim Biophys Acta $x MED00000539
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Možnosti archivace