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CEITEC Central European Institute of ... 1 Department of Integrative Biology and... 1 Department of Neurochemistry Palladin... 1 Department of Physics of Biological S... 1 Institute of Organic Chemistry and Bi... 1 Laboratoire Chrono Environnement UMR ... 1 Plateforme PACE Laboratoire de Pharma... 1 Receptor AI Inc 20 22 Wenlock Road Lo... 1 UFR des Sciences de Santé Université ... 1 UMR 1231 Lipides Nutrition Cancer INS... 1 Université Paris Saclay CNRS Institut... 1
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CEITEC Central European Institute of ... 1 Department of Integrative Biology and... 1 Department of Neurochemistry Palladin... 1 Department of Physics of Biological S... 1 Institute of Organic Chemistry and Bi... 1 Laboratoire Chrono Environnement UMR ... 1 Plateforme PACE Laboratoire de Pharma... 1 Receptor AI Inc 20 22 Wenlock Road Lo... 1 UFR des Sciences de Santé Université ... 1 UMR 1231 Lipides Nutrition Cancer INS... 1 Université Paris Saclay CNRS Institut... 1
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Lirussi, Frédéric
Autor Lirussi, Frédéric UMR 1231, Lipides Nutrition Cancer, INSERM, F-21000 Dijon, France UFR des Sciences de Santé, Université Bourgogne Franche-Comté, F-25000 Besançon, France Plateforme PACE, Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalo-Universitaire Besançon, F-25000 Besançon, France. Electronic address: frederic.lirussi@u-bourgogne.fr
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Pyrshev, Kyrylo
Autor Pyrshev, Kyrylo UFR des Sciences de Santé, Université Bourgogne Franche-Comté, F-25000 Besançon, France Department of Physics of Biological Systems, Institute of Physics of the National Academy of Sciences of Ukraine, 46 Nauky ave, 03028 Kyiv, Ukraine Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA Department of Neurochemistry, Palladin Institute of Biochemistry of the NAS of Ukraine, 9 Leontovycha str., 01601 Kyiv, Ukraine
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Yesylevskyy, Semen
Autor Yesylevskyy, Semen Department of Physics of Biological Systems, Institute of Physics of the National Academy of Sciences of Ukraine, 46 Nauky ave, 03028 Kyiv, Ukraine Laboratoire Chrono Environnement UMR CNRS 6249, Université de Bourgogne Franche-Comté, 16 route de Gray, 25030 Besançon Cedex, France Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, CZ-166 10, Prague 6, Czech Republic Receptor.AI Inc, 20-22 Wenlock Road, London N1 7GU, United Kingdom
- Rivel, Timothée
- Lopez, Tatiana
- Coppens, Eleonore
- Mura, Simona
- Couvreur, Patrick
- Ramseyer, Christophe
PubMed
36494037
DOI
10.1016/j.bbadis.2022.166614
Knihovny.cz E-zdroje
Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue.
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