• Je něco špatně v tomto záznamu ?

Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions

S. Vinayagamurthy, S. Bagri, JL. Mergny, S. Chowdhury

. 2023 ; 39 (1) : 59-73. [pub] 20221117

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22032015

Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome - through factors that associate at telomeres and genome wide - and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032015
003      
CZ-PrNML
005      
20230131150631.0
007      
ta
008      
230120s2023 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.tig.2022.10.002 $2 doi
035    __
$a (PubMed)36404192
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Vinayagamurthy, Soujanya $u Integrative and Functional Biology Unit, CSIR Institute of Genomics and Integrative Biology, New Delhi 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
245    10
$a Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions / $c S. Vinayagamurthy, S. Bagri, JL. Mergny, S. Chowdhury
520    9_
$a Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome - through factors that associate at telomeres and genome wide - and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.
650    12
$a telomery $x genetika $x metabolismus $7 D016615
650    _2
$a DNA $x metabolismus $7 D004247
650    12
$a G-kvadruplexy $7 D054856
650    _2
$a heterochromatin $7 D006570
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Bagri, Sulochana $u Integrative and Functional Biology Unit, CSIR Institute of Genomics and Integrative Biology, New Delhi 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
700    1_
$a Mergny, Jean-Louis $u Institute of Biophysics of the CAS, v.v.i. Královopolská 135, 612 65 Brno, Czech Republic; Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, 91128 Palaiseau, France
700    1_
$a Chowdhury, Shantanu $u Integrative and Functional Biology Unit, CSIR Institute of Genomics and Integrative Biology, New Delhi 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; GNR Knowledge Centre for Genome and Informatics, CSIR Institute of Genomics and Integrative Biology, New Delhi 110025, India. Electronic address: shantanuc@igib.in
773    0_
$w MED00010699 $t Trends in genetics : TIG $x 0168-9525 $g Roč. 39, č. 1 (2023), s. 59-73
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36404192 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131150627 $b ABA008
999    __
$a ok $b bmc $g 1891039 $s 1183350
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 39 $c 1 $d 59-73 $e 20221117 $i 0168-9525 $m Trends in genetics $n Trends Genet $x MED00010699
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Možnosti archivace