-
Something wrong with this record ?
Altered hearing function in mice with implanted cranial windows
N. Jovanović, Š. Suchánková, M. Kang, A. Melichar, Z. Bureš, R. Tureček
Language English Country Ireland
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Prostheses and Implants MeSH
- Hearing * MeSH
- Evoked Potentials, Auditory, Brain Stem MeSH
- Reflex, Startle * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The cranial window technique has proven to be an effective method for in vivo imaging of cortical activity. However, given the invasive nature of this procedure, possible side effects could be expected in the nervous system. In this study, we evaluated the effects of unilateral cranial window surgery on auditory function in C57BL6 mice using electrophysiological and behavioral approaches. We found that one week after implantation, mice exhibited both increased thresholds and decreased amplitudes of their auditory brainstem responses. These changes were accompanied by a decrease in distortion product otoacoustic emissions, indicating a deterioration in cochlear function. In addition, behavioral testing of these mice revealed reduced suppression of their acoustic startle response by gap prepulse, suggesting a deficit in auditory processing or possibly the presence of tinnitus. The changes in auditory function appeared to be only partially reversible within four weeks after surgery. Thus, our findings suggest that cranial window implantation causes long-term functional changes in the auditory system that should be considered when interpreting data from optical imaging techniques.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22032017
- 003
- CZ-PrNML
- 005
- 20230131151448.0
- 007
- ta
- 008
- 230120s2023 ie f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.neulet.2022.136969 $2 doi
- 035 __
- $a (PubMed)36402256
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ie
- 100 1_
- $a Jovanović, Nataša $u Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic; Second Faculty of Medicine, Charles University, 150 06 Prague, Czech Republic
- 245 10
- $a Altered hearing function in mice with implanted cranial windows / $c N. Jovanović, Š. Suchánková, M. Kang, A. Melichar, Z. Bureš, R. Tureček
- 520 9_
- $a The cranial window technique has proven to be an effective method for in vivo imaging of cortical activity. However, given the invasive nature of this procedure, possible side effects could be expected in the nervous system. In this study, we evaluated the effects of unilateral cranial window surgery on auditory function in C57BL6 mice using electrophysiological and behavioral approaches. We found that one week after implantation, mice exhibited both increased thresholds and decreased amplitudes of their auditory brainstem responses. These changes were accompanied by a decrease in distortion product otoacoustic emissions, indicating a deterioration in cochlear function. In addition, behavioral testing of these mice revealed reduced suppression of their acoustic startle response by gap prepulse, suggesting a deficit in auditory processing or possibly the presence of tinnitus. The changes in auditory function appeared to be only partially reversible within four weeks after surgery. Thus, our findings suggest that cranial window implantation causes long-term functional changes in the auditory system that should be considered when interpreting data from optical imaging techniques.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a myši $7 D051379
- 650 12
- $a úleková reakce $7 D013216
- 650 _2
- $a myši inbrední C57BL $7 D008810
- 650 12
- $a sluch $7 D006309
- 650 _2
- $a protézy a implantáty $7 D019736
- 650 _2
- $a sluchové kmenové evokované potenciály $7 D016057
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Suchánková, Štěpánka $u Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic
- 700 1_
- $a Kang, Minseok $u Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic
- 700 1_
- $a Melichar, Adolf $u Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic; Second Faculty of Medicine, Charles University, 150 06 Prague, Czech Republic
- 700 1_
- $a Bureš, Zbyněk $u Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic; Department of Cognitive Systems and Neurosciences, Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University, Jugoslávských, partyzánů 1580/3, 160 00 Prague 6, Czech Republic
- 700 1_
- $a Tureček, Rostislav $u Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic. Electronic address: rostislav.turecek@iem.cas.cz
- 773 0_
- $w MED00003507 $t Neuroscience letters $x 1872-7972 $g Roč. 792, č. - (2023), s. 136969
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36402256 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230120 $b ABA008
- 991 __
- $a 20230131151444 $b ABA008
- 999 __
- $a ok $b bmc $g 1891040 $s 1183352
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 792 $c - $d 136969 $e 20221117 $i 1872-7972 $m Neuroscience letters $n Neurosci. lett. $x MED00003507
- LZP __
- $a Pubmed-20230120