Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.
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- lidé MeSH
- mozek metabolismus růst a vývoj MeSH
- sluch * fyziologie MeSH
- sluchová dráha * fyziologie MeSH
- sluchové korové centrum metabolismus fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Na základě porovnání odpovědí z originálního dotazníku ohledně hlukové zátěže hudebním hlukem prostřednictvím sluchátek a dalšími hlučnými aktivitami u mladých lidí ve věku 16–18 let s výsledky audiometrického vyšetření pomocí prahového tónového audiogramu bylo potvrzeno, na rozdíl od obecně rozšířených informací, že u této věkové skupiny nedochází k postižení sluchu. Tuto skutečnost vysvětlujeme nízkým věkem vyšetřovaných, tedy vysokou odolností sluchového aparátu vůči hluku. Podobné výsledky jsou uváděny i v současné odborné literatuře, která je v této problematice výrazně chudá. V české literatuře nebyly doposud podobné výsledky publikovány vůbec. Pokud byly podle literatury nalezeny iniciální příznaky sluchového postižení, pak výhradně ve vysokofrekvenční audiometrické oblasti. Na otázku, zda jsou naše vyšetřovací metody dostatečně citlivé vzhledem k poškození sluchu hlukem, je jasná odpověď ne. Pokud bychom chtěli zaznamenávat preventivně již počáteční stavy poškození sluchu z hluku, a to i hudebního, konzumovaného prostřednictvím sluchátek, pak musíme vyšetřovat vysokofrekvenční audiometrií.
Based on the comparison of the answers from the original questionnaire regarding the noise burden of music noise through headphones and other noisy activities in young people aged 16–18 years with the results of an audiometric examination using a threshold tone audiogram, it was confirmed, contrary to the generally widespread information, that in this age group, there is no hearing impairment. We explain this fact by the young age of the examinees, i.e. the high resistance of the hearing apparatus to noise. Similar results are also reported in current professional literature, which is significantly poor in this issue. Similar results have not yet been published in the Czech literature. If, according to the literature, initial symptoms of hearing impairment were found, then exclusively in the high-frequency audiometric area. The answer to the question whether “are our investigation methods sensitive enough to noise-induced hearing damage” is a clear NO. If we would like to record preventively the initial states of hearing damage from noise, including music consumed through headphones, then we must investigate with high-frequency audiometry.
- MeSH
- audiometrie * metody statistika a číselné údaje MeSH
- hluk * škodlivé účinky MeSH
- hudba MeSH
- lidé MeSH
- mladiství MeSH
- mobilní telefon přístrojové vybavení statistika a číselné údaje MeSH
- poruchy sluchu etiologie MeSH
- průzkumy a dotazníky MeSH
- sluch MeSH
- statistika jako téma MeSH
- věkové faktory MeSH
- volnočasové aktivity MeSH
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- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
BACKGROUND: During otosclerosis surgery, operative trauma can lead to decreased bone conduction. AIMS: The study aims to observe the bone conduction changes after otosclerosis operations and analyse possible factors affecting the postoperative decrease in bone conduction. MATERIAL AND METHODS: Authors retrospectively processed the data of 109 patients and evaluated pure tone audiometry before surgery and consequently 2 days, 1 month and 1 year after surgery. RESULTS: We noted a deterioration of bone conduction >5 dB on the second postoperative day in 28% (30/109) of patients, which persisted one year after the surgery in 9% (10/109) cases. Analysis of individual factors affecting bone conduction loss revealed a higher risk of permanent loss of bone conduction in patients with early postoperative loss in higher frequencies, in older patients and patients with a preoperative threshold of bone conduction >20 dB. Revision surgery was not a statistically significant factor. CONCLUSION AND SIGNIFICANCE: The bone conduction decrease after otosclerosis surgery is usually temporary. The recovery of bone conduction is influenced by the age of patients and the level of bone conduction before the surgery. The early postoperative decrease of bone conduction in higher frequencies is a negative predictive factor for permanent hearing loss.
- MeSH
- audiometrie čistými tóny * MeSH
- chirurgie třmínku * MeSH
- dospělí MeSH
- kostní vedení zvuku * MeSH
- lidé středního věku MeSH
- lidé MeSH
- otoskleróza * chirurgie patofyziologie komplikace MeSH
- percepční nedoslýchavost * etiologie patofyziologie MeSH
- pooperační komplikace * etiologie patofyziologie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The cranial window technique has proven to be an effective method for in vivo imaging of cortical activity. However, given the invasive nature of this procedure, possible side effects could be expected in the nervous system. In this study, we evaluated the effects of unilateral cranial window surgery on auditory function in C57BL6 mice using electrophysiological and behavioral approaches. We found that one week after implantation, mice exhibited both increased thresholds and decreased amplitudes of their auditory brainstem responses. These changes were accompanied by a decrease in distortion product otoacoustic emissions, indicating a deterioration in cochlear function. In addition, behavioral testing of these mice revealed reduced suppression of their acoustic startle response by gap prepulse, suggesting a deficit in auditory processing or possibly the presence of tinnitus. The changes in auditory function appeared to be only partially reversible within four weeks after surgery. Thus, our findings suggest that cranial window implantation causes long-term functional changes in the auditory system that should be considered when interpreting data from optical imaging techniques.
Swept-sines provide a tool for fast and high-resolution measurement of evoked otoacoustic emissions. During the measurement, a response to swept-sine(s) is recorded by a probe placed in the ear canal. Otoacoustic emissions can then be extracted by various techniques, e.g., Fourier analysis, the heterodyne method, and the least-square-fitting (LSF) technique. This paper employs a technique originally proposed with exponential swept-sines, which allows for direct emission extraction from the measured intermodulation impulse response. It is shown here that the technique can be used to extract distortion-product otoacoustic emissions (DPOAEs) evoked with two simultaneous swept-sines. For proper extraction of the DPOAE phase, the technique employs previously proposed adjusted formulas for exponential swept-sines generating so-called synchronized swept-sines (SSSs). Here, the SSS technique is verified using responses derived from a numerical solution of a cochlear model and responses measured in human subjects. Although computationally much less demanding, the technique yields comparable results to those obtained by the LSF technique, which has been shown in the literature to be the most noise-robust among the emission extraction methods.
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- Fourierova analýza MeSH
- kochlea * fyziologie MeSH
- lidé MeSH
- otoakustické emise spontánní * fyziologie MeSH
- zvukovod fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
PURPOSE: This study aimed to determine hearing thresholds in an otologically normal population without occupational noise exposure aged 18 to 64 years using extended high-frequency audiometry (EHFA). METHODS: Individuals from the general population who have never had hearing problems and whose job was not associated with noise exposure were included in the study and classified by age into 5 categories: 18-24 and, further, by 10 years of age. Each of these groups was further divided according to gender. All subjects underwent tympanometry, conventional pure-tone audiometry within the 0.125-8 kHz range, and extended high-frequency audiometry within the 9-16 kHz range, performed according to the standards. The significance level for statistical testing was set at 5%. RESULTS: Here, we established hearing thresholds in an otologically healthy population within the extended high-frequency (EHF) range (9-16 kHz). We found the EHFA to be a highly sensitive method for early detection of hearing loss, with hearing thresholds decreasing as soon as 35 years of age. In males, the hearing thresholds grew with age more rapidly than in women. The ability to respond at EHF gradually decreased with age and increasing frequency. CONCLUSION: Our results can help improve the knowledge of EHF hearing thresholds for individual sexes and age groups. So far, the standard 7029:2017 is not binding and, moreover, it only reaches up to the frequency of 12.5 kHz. EHFA is a highly sensitive method for the evaluation of hearing loss depending on age and sex.
- MeSH
- akustické impedanční testy MeSH
- audiometrie čistými tóny MeSH
- audiometrie MeSH
- dítě MeSH
- dospělí MeSH
- hluchota * MeSH
- lidé MeSH
- nedoslýchavost z hluku * diagnóza MeSH
- nedoslýchavost * diagnóza MeSH
- sluch MeSH
- sluchový práh MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- čití, cítění * fyziologie MeSH
- lidé MeSH
- percepce * fyziologie MeSH
- poruchy senzitivity diagnóza klasifikace patologie MeSH
- poruchy sluchu diagnóza patologie MeSH
- poruchy zraku diagnóza klasifikace patologie MeSH
- sluch fyziologie MeSH
- somatosenzorické poruchy diagnóza patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- deprese farmakoterapie MeSH
- extrakt z ginkgo aplikace a dávkování MeSH
- Ginkgo biloba * MeSH
- kardiovaskulární systém účinky léků MeSH
- kombinovaná farmakoterapie MeSH
- léková kontraindikace MeSH
- listy rostlin MeSH
- nemoci mozku farmakoterapie MeSH
- sluch účinky léků MeSH
- terapeutické užití MeSH
- zrak účinky léků MeSH
- Publikační typ
- populární práce MeSH
