-
Je něco špatně v tomto záznamu ?
Diagnostic discrimination of a novel high-sensitivity cardiac troponin I assay and derivation/validation of an assay-specific 0/1h-algorithm
L. Koechlin, J. Boeddinghaus, P. Lopez-Ayala, T. Nestelberger, D. Wussler, F. Mais, R. Twerenbold, T. Zimmermann, K. Wildi, AM. Köppen, Ò. Miró, FJ. Martin-Sanchez, D. Kawecki, N. Geigy, DI. Keller, M. Christ, A. Buser, MR. Giménez, L....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
NLK
ProQuest Central
od 2002-01-01 do Před 2 měsíci
Nursing & Allied Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Health & Medicine (ProQuest)
od 2002-01-01 do Před 2 měsíci
Health Management Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Public Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
- MeSH
- biologické markery MeSH
- infarkt myokardu * diagnóza MeSH
- lidé MeSH
- prospektivní studie MeSH
- ROC křivka MeSH
- troponin I * MeSH
- troponin T MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: We aimed to assess the diagnostic utility of the Dimension EXL LOCI High-Sensitivity Troponin I (hs-cTnI-EXL) assay. METHODS: This multicenter study included patients with chest discomfort presenting to the emergency department. Diagnoses were centrally and independently adjudicated by two cardiologists using all available clinical information. Adjudication was performed twice including serial measurements of high-sensitivity cardiac troponin (hs-cTn) I-Architect (primary analysis) and serial measurements of hs-cTnT-Elecsys (secondary analysis) in addition to the clinically used (hs)-cTn. The primary objective was to assess and compare the discriminatory performance of hs-cTnI-EXL, hs-cTnI-Architect and hs-cTnT-Elecsys for acute myocardial infarction (MI). Furthermore, we derived and validated a hs-cTnI-EXL-specific 0/1h-algorithm. RESULTS: Adjudicated MI was the diagnosis in 204/1454 (14%) patients. The area under the receiver operating characteristics curve for hs-cTnI-EXL was 0.94 (95%CI, 0.93-0.96), and comparable to hs-cTnI-Architect (0.95; 95%CI, 0.93-0.96) and hs-cTnT-Elecsys (0.93; 95%CI, 0.91-0.95). In the derivation cohort (n = 813), optimal criteria for rule-out of MI were <9ng/L at presentation (if chest pain onset >3h) or <9ng/L and 0h-1h-change <5ng/L, and for rule-in ≥160ng/L at presentation or 0h-1h-change ≥100ng/L. In the validation cohort (n = 345), these cut-offs ruled-out 56% of patients (negative predictive value 99.5% (95%CI, 97.1-99.9), sensitivity 97.8% (95%CI, 88.7-99.6)), and ruled-in 9% (positive predictive value 83.3% (95%CI, 66.4-92.7), specificity 98.3% (95%CI, 96.1-99.3)). Secondary analyses using adjudication based on hs-cTnT measurements confirmed the findings. CONCLUSIONS: The overall performance of the hs-cTnI-EXL was comparable to best-validated hs-cTnT/I assays and an assay-specific 0/1h-algorithm safely rules out and accurately rules in acute MI. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov number, NCT00470587.
BHF University Centre for Cardiovascular Science University of Edinburgh Edinburgh UK
Critical Care Research Group and the University of Queensland Brisbane Queensland Australia
Department of Cardiac Surgery University Hospital Basel University of Basel Basel Basel Switzerland
Department of Cardiology Heart Center Leipzig University of Leipzig Leipzig Saxony Germany
Division of Internal Medicine University Hospital Basel University of Basel Basel Basel Switzerland
Emergency Department Hospital Clinic Barcelona Catalonia Spain
Emergency Department Kantonsspital Liestal Liestal Liestal Switzerland
Emergency Department Kantonsspital Luzern Luzern Luzern Switzerland
Emergency Department University Hospital Zurich Zurich Zurich Switzerland
GREAT network Basel Basel Switzerland
Institute of Laboratory Medicine County Hospital Aarau Aarau Aarau Switzerland
Servicio de Urgencias Hospital Clínico San Carlos Madrid Madrid Spain
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22032061
- 003
- CZ-PrNML
- 005
- 20230131150657.0
- 007
- ta
- 008
- 230120s2023 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ahj.2022.10.007 $2 doi
- 035 __
- $a (PubMed)36243111
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Koechlin, Luca $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; Department of Cardiac Surgery, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland. Electronic address: luca.koechlin@usb.ch
- 245 10
- $a Diagnostic discrimination of a novel high-sensitivity cardiac troponin I assay and derivation/validation of an assay-specific 0/1h-algorithm / $c L. Koechlin, J. Boeddinghaus, P. Lopez-Ayala, T. Nestelberger, D. Wussler, F. Mais, R. Twerenbold, T. Zimmermann, K. Wildi, AM. Köppen, Ò. Miró, FJ. Martin-Sanchez, D. Kawecki, N. Geigy, DI. Keller, M. Christ, A. Buser, MR. Giménez, L. Bernasconi, A. Hammerer-Lercher, C. Mueller, APACE investigators
- 520 9_
- $a BACKGROUND: We aimed to assess the diagnostic utility of the Dimension EXL LOCI High-Sensitivity Troponin I (hs-cTnI-EXL) assay. METHODS: This multicenter study included patients with chest discomfort presenting to the emergency department. Diagnoses were centrally and independently adjudicated by two cardiologists using all available clinical information. Adjudication was performed twice including serial measurements of high-sensitivity cardiac troponin (hs-cTn) I-Architect (primary analysis) and serial measurements of hs-cTnT-Elecsys (secondary analysis) in addition to the clinically used (hs)-cTn. The primary objective was to assess and compare the discriminatory performance of hs-cTnI-EXL, hs-cTnI-Architect and hs-cTnT-Elecsys for acute myocardial infarction (MI). Furthermore, we derived and validated a hs-cTnI-EXL-specific 0/1h-algorithm. RESULTS: Adjudicated MI was the diagnosis in 204/1454 (14%) patients. The area under the receiver operating characteristics curve for hs-cTnI-EXL was 0.94 (95%CI, 0.93-0.96), and comparable to hs-cTnI-Architect (0.95; 95%CI, 0.93-0.96) and hs-cTnT-Elecsys (0.93; 95%CI, 0.91-0.95). In the derivation cohort (n = 813), optimal criteria for rule-out of MI were <9ng/L at presentation (if chest pain onset >3h) or <9ng/L and 0h-1h-change <5ng/L, and for rule-in ≥160ng/L at presentation or 0h-1h-change ≥100ng/L. In the validation cohort (n = 345), these cut-offs ruled-out 56% of patients (negative predictive value 99.5% (95%CI, 97.1-99.9), sensitivity 97.8% (95%CI, 88.7-99.6)), and ruled-in 9% (positive predictive value 83.3% (95%CI, 66.4-92.7), specificity 98.3% (95%CI, 96.1-99.3)). Secondary analyses using adjudication based on hs-cTnT measurements confirmed the findings. CONCLUSIONS: The overall performance of the hs-cTnI-EXL was comparable to best-validated hs-cTnT/I assays and an assay-specific 0/1h-algorithm safely rules out and accurately rules in acute MI. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov number, NCT00470587.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a biologické markery $7 D015415
- 650 12
- $a troponin I $7 D019210
- 650 _2
- $a ROC křivka $7 D012372
- 650 12
- $a infarkt myokardu $x diagnóza $7 D009203
- 650 _2
- $a troponin T $7 D020107
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Boeddinghaus, Jasper $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; BHF/University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
- 700 1_
- $a Lopez-Ayala, Pedro $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland
- 700 1_
- $a Nestelberger, Thomas $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland; Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
- 700 1_
- $a Wussler, Desiree $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, University of Basel, Basel, Basel, Switzerland
- 700 1_
- $a Mais, Felix $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; Emergency Department, University Hospital Zurich, Zurich, Zurich, Switzerland
- 700 1_
- $a Twerenbold, Raphael $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; University Center of Cardiovascular Science & Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany
- 700 1_
- $a Zimmermann, Tobias $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland
- 700 1_
- $a Wildi, Karin $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland; Critical Care Research Group and the University of Queensland, Brisbane, Queensland, Australia
- 700 1_
- $a Köppen, Anne Marie $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland
- 700 1_
- $a Miró, Òscar $u GREAT network, Basel, Basel, Switzerland; Emergency Department, Hospital Clinic, Barcelona, Catalonia, Spain
- 700 1_
- $a Martin-Sanchez, F Javier $u GREAT network, Basel, Basel, Switzerland; Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Madrid, Spain
- 700 1_
- $a Kawecki, Damian $u GREAT network, Basel, Basel, Switzerland; 2nd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Katowice, Silesian, Poland
- 700 1_
- $a Geigy, Nicolas $u Emergency Department, Kantonsspital Liestal, Liestal Liestal, Switzerland
- 700 1_
- $a Keller, Dagmar I $u Emergency Department, University Hospital Zurich, Zurich, Zurich, Switzerland
- 700 1_
- $a Christ, Michael $u Emergency Department, Kantonsspital Luzern, Luzern, Luzern, Switzerland
- 700 1_
- $a Buser, Andreas $u Department of hematology and Blood Bank, University Hospital Basel, University of Basel, Basel, Basel Switzerland
- 700 1_
- $a Giménez, Maria Rubini $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; Department of Cardiology, Heart Center Leipzig, University of Leipzig, Leipzig, Saxony, Germany
- 700 1_
- $a Bernasconi, Luca $u Institute of Laboratory Medicine, County Hospital Aarau, Aarau, Aarau, Switzerland
- 700 1_
- $a Hammerer-Lercher, Angelika $u Institute of Laboratory Medicine, County Hospital Aarau, Aarau, Aarau, Switzerland
- 700 1_
- $a Mueller, Christian $u Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Basel, Switzerland; GREAT network, Basel, Basel, Switzerland. Electronic address: christian.mueller@usb.ch
- 710 2_
- $a APACE investigators
- 773 0_
- $w MED00000228 $t American heart journal $x 1097-6744 $g Roč. 255, č. - (2023), s. 58-70
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36243111 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230120 $b ABA008
- 991 __
- $a 20230131150653 $b ABA008
- 999 __
- $a ok $b bmc $g 1891062 $s 1183396
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 255 $c - $d 58-70 $e 20221013 $i 1097-6744 $m The American heart journal $n Am Heart J $x MED00000228
- LZP __
- $a Pubmed-20230120
