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Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope
MI. Del Principe, D. Seidel, M. Criscuolo, M. Dargenio, Z. Rácil, M. Piedimonte, F. Marchesi, G. Nadali, P. Koehler, N. Fracchiolla, C. Cattaneo, N. Klimko, A. Spolzino, D. Yilmaz Karapinar, H. Demiraslan, RF. Duarte, J. Demeter, M. Stanzani,...
Jazyk angličtina Země Německo
Typ dokumentu multicentrická studie, časopisecké články
PubMed
36064299
DOI
10.1111/myc.13524
Knihovny.cz E-zdroje
- MeSH
- antifungální látky terapeutické užití MeSH
- dítě MeSH
- dospělí MeSH
- echinokandiny terapeutické užití MeSH
- hematologie * MeSH
- kandidemie * farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- prognóza MeSH
- senioři MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Our multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. METHODS: HM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia. RESULTS: Among 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2-78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty-six (40%) of Magnusiomyces-associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p < .0001). First-line antifungal therapy with azoles, alone or in combination, was associated with improved response compared to other antifungals (p = .001). Overall day-30 mortality rate was 43%. Factors associated with higher mortality rates were septic shock (HR 2.696, 95% CI 1.396-5.204, p = .003), corticosteroid treatment longer than 14 days (HR 2.245, 95% CI 1.151-4.376, p = .018) and lack of neutrophil recovery (HR 3.997, 95% CI 2.102-7.601, p < .001). The latter was independently associated with poor outcome (HR 2.495, 95% CI 1.192-5.222, p = .015). CONCLUSIONS: Magnusiomyces-associated infections are often breakthrough infections. Effective treatment regimens of these infections remain to be determined, but neutrophil recovery appears to play an important role in the favourable outcome.
Clinical Microbiology and Parasitology Department University Hospital La Paz Madrid Spain
Department of Hematology Centre Henri Becquerel Rouen France
Department of Hematology Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain
Department of Infectious Diseases Faculty of Medicine Erciyes University Kayseri Turkey
Dipartimento di Biomedicina e Prevenzione Università degli studi di Roma Tor Vergata Roma Italy
Division of Hematology ASST Sette Laghi Ospedale di Circolo e Fondazione Macchi Varese Italy
Divisione di Ematologia ASST Spedali Civili di Brescia Brescia Italy
Ematologia e Trapianto di Cellule Staminali Ospedale Vito Fazzi Lecce Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico UOC di Ematologia Milano Italy
German Centre for Infection Research Partner Site Bonn Cologne Cologne Germany
Hematology and Stem Cell Transplant Unit IRCCS Regina Elena National Cancer Institute Roma Italy
Hospital de la Santa Creu i Sant Pau Barcelona Spain
Institute of Haematology and Blood Transfusion Prague Czech Republic
Onco Hematology Department of Oncology Veneto Institute of Oncology IOV IRCCS Padua Italy
Schneider Children's Medical Center Faculty of Medicine Tel Aviv University Tel Aviv Israel
Stem Cell Transplant Center AOU Citta' della Salute e della Scienza Torino Italy
U O C Ematologia P O A Tortora Pagani Salerno Italy
UOC Ematologia e Trapianto di Cellule Staminali Emopoietiche Policlinico Riuniti Foggia Foggia Italy
Citace poskytuje Crossref.org
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- $a Del Principe, Maria Ilaria $u Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma "Tor Vergata", Roma, Italy $1 https://orcid.org/0000000239580669
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- $a Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope / $c MI. Del Principe, D. Seidel, M. Criscuolo, M. Dargenio, Z. Rácil, M. Piedimonte, F. Marchesi, G. Nadali, P. Koehler, N. Fracchiolla, C. Cattaneo, N. Klimko, A. Spolzino, D. Yilmaz Karapinar, H. Demiraslan, RF. Duarte, J. Demeter, M. Stanzani, LMA. Melillo, CM. Basilico, S. Cesaro, G. Paterno, C. Califano, M. Delia, E. Buzzatti, A. Busca, N. Alakel, VA. Arsenijevi'c, V. Camus, I. Falces-Romero, L. Itzhak, M. Kouba, R. Martino, P. Sedlacek, B. Weinbergerová, OA. Cornely, L. Pagano, FUNGISCOPE (Global Emerging Fungal Infection Registry) and the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie)
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