• Something wrong with this record ?

Perineuronal nets affect memory and learning after synapse withdrawal

J. Ruzicka, M. Dalecka, K. Safrankova, D. Peretti, P. Jendelova, JCF. Kwok, JW. Fawcett

. 2022 ; 12 (1) : 480. [pub] 20221115

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22032655

Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store and that they remain stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naïve animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage for correction of deficits.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032655
003      
CZ-PrNML
005      
20230131151811.0
007      
ta
008      
230120s2022 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41398-022-02226-z $2 doi
035    __
$a (PubMed)36379919
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Ruzicka, Jiri $u Institute of Experimental Medicine, CAS, Prague, Czech Republic $1 https://orcid.org/0000000212691633
245    10
$a Perineuronal nets affect memory and learning after synapse withdrawal / $c J. Ruzicka, M. Dalecka, K. Safrankova, D. Peretti, P. Jendelova, JCF. Kwok, JW. Fawcett
520    9_
$a Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store and that they remain stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naïve animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage for correction of deficits.
650    _2
$a zvířata $7 D000818
650    12
$a synapse $7 D013569
650    12
$a extracelulární matrix $7 D005109
650    _2
$a neurony $x fyziologie $7 D009474
650    _2
$a učení $7 D007858
650    _2
$a extracelulární matrix - proteiny $7 D016326
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Dalecka, Marketa $u Imaging Methods Core Facility, BIOCEV, CAS, Vestec, Czech Republic $1 https://orcid.org/0000000343660255
700    1_
$a Safrankova, Kristyna $u Institute of Experimental Medicine, CAS, Prague, Czech Republic
700    1_
$a Peretti, Diego $u UK Dementia Research Institute and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
700    1_
$a Jendelova, Pavla $u Institute of Experimental Medicine, CAS, Prague, Czech Republic $1 https://orcid.org/0000000246449212
700    1_
$a Kwok, Jessica C F $u Institute of Experimental Medicine, CAS, Prague, Czech Republic $u Faculty of Biological Sciences, University of Leeds, Leeds, UK $1 https://orcid.org/0000000297989083
700    1_
$a Fawcett, James W $u Institute of Experimental Medicine, CAS, Prague, Czech Republic. JF108@cam.ac.uk $u John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK. JF108@cam.ac.uk $1 https://orcid.org/0000000279904568
773    0_
$w MED00177206 $t Translational psychiatry $x 2158-3188 $g Roč. 12, č. 1 (2022), s. 480
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36379919 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131151807 $b ABA008
999    __
$a ok $b bmc $g 1891421 $s 1183990
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 12 $c 1 $d 480 $e 20221115 $i 2158-3188 $m Translational psychiatry $n Transl Psychiatr $x MED00177206
LZP    __
$a Pubmed-20230120

Find record

Citation metrics

Archiving options