• Je něco špatně v tomto záznamu ?

Mitochondrial oxygen sensing of acute hypoxia in specialized cells - Is there a unifying mechanism

O. Pak, A. Nolte, F. Knoepp, L. Giordano, P. Pecina, M. Hüttemann, LI. Grossman, N. Weissmann, N. Sommer

. 2022 ; 1863 (8) : 148911. [pub] 20220819

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, přehledy, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22032878

Acclimation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation and thus oxygen supply to the tissues. Acute oxygen sensing by these cells triggers hyperventilation and hypoxic pulmonary vasoconstriction which limits pulmonary blood flow through areas of low alveolar oxygen content. Oxygen sensing of acute hypoxia by specialized cells thus is a fundamental pre-requisite for aerobic life and maintains systemic oxygen supply. However, the primary oxygen sensing mechanism and the question of a common mechanism in different specialized oxygen sensing cells remains unresolved. Recent studies unraveled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that is essential for the hypoxia-induced release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses in both, the carotid body and pulmonary vasculature. This review compares basic mitochondrial oxygen sensing mechanisms in the pulmonary vasculature and the carotid body.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032878
003      
CZ-PrNML
005      
20230131151612.0
007      
ta
008      
230120s2022 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.bbabio.2022.148911 $2 doi
035    __
$a (PubMed)35988811
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Pak, Oleg $u Justus Liebig University, Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
245    10
$a Mitochondrial oxygen sensing of acute hypoxia in specialized cells - Is there a unifying mechanism / $c O. Pak, A. Nolte, F. Knoepp, L. Giordano, P. Pecina, M. Hüttemann, LI. Grossman, N. Weissmann, N. Sommer
520    9_
$a Acclimation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation and thus oxygen supply to the tissues. Acute oxygen sensing by these cells triggers hyperventilation and hypoxic pulmonary vasoconstriction which limits pulmonary blood flow through areas of low alveolar oxygen content. Oxygen sensing of acute hypoxia by specialized cells thus is a fundamental pre-requisite for aerobic life and maintains systemic oxygen supply. However, the primary oxygen sensing mechanism and the question of a common mechanism in different specialized oxygen sensing cells remains unresolved. Recent studies unraveled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that is essential for the hypoxia-induced release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses in both, the carotid body and pulmonary vasculature. This review compares basic mitochondrial oxygen sensing mechanisms in the pulmonary vasculature and the carotid body.
650    12
$a respirační komplex IV $x metabolismus $7 D003576
650    _2
$a lidé $7 D006801
650    _2
$a hypoxie $7 D000860
650    12
$a kyslík $x metabolismus $7 D010100
650    _2
$a protein - isoformy $7 D020033
650    _2
$a reaktivní formy kyslíku $x metabolismus $7 D017382
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Nolte, Anika $u Justus Liebig University, Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
700    1_
$a Knoepp, Fenja $u Justus Liebig University, Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
700    1_
$a Giordano, Luca $u Justus Liebig University, Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
700    1_
$a Pecina, Petr $u Laboratory of Bioenergetics, Institute of Physiology CAS, Prague, Czech Republic
700    1_
$a Hüttemann, Maik $u Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
700    1_
$a Grossman, Lawrence I $u Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
700    1_
$a Weissmann, Norbert $u Justus Liebig University, Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
700    1_
$a Sommer, Natascha $u Justus Liebig University, Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany. Electronic address: Natascha.Sommer@innere.med.uni-giessen.de
773    0_
$w MED00000712 $t Biochimica et biophysica acta. Bioenergetics $x 1879-2650 $g Roč. 1863, č. 8 (2022), s. 148911
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35988811 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131151608 $b ABA008
999    __
$a ok $b bmc $g 1891557 $s 1184213
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 1863 $c 8 $d 148911 $e 20220819 $i 1879-2650 $m Biochimica et biophysica acta. Bioenergetics $n Biochem Biophys Acta $x MED00000712
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Možnosti archivace