Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation

J. Gruchot, F. Lein, I. Lewen, L. Reiche, V. Weyers, P. Petzsch, P. Göttle, K. Köhrer, HP. Hartung, P. Küry, D. Kremer

. 2022 ; 23 (21) : . [pub] 20221031

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22032953

Siponimod (Mayzent®), a sphingosine 1-phosphate receptor (S1PR) modulator which prevents lymphocyte egress from lymphoid tissues, is approved for the treatment of relapsing-remitting and active secondary progressive multiple sclerosis. It can cross the blood-brain barrier (BBB) and selectively binds to S1PR1 and S1PR5 expressed by several cell populations of the central nervous system (CNS) including microglia. In multiple sclerosis, microglia are a key CNS cell population moving back and forth in a continuum of beneficial and deleterious states. On the one hand, they can contribute to neurorepair by clearing myelin debris, which is a prerequisite for remyelination and neuroprotection. On the other hand, they also participate in autoimmune inflammation and axonal degeneration by producing pro-inflammatory cytokines and molecules. In this study, we demonstrate that siponimod can modulate the microglial reaction to lipopolysaccharide-induced pro-inflammatory activation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032953
003      
CZ-PrNML
005      
20230131150753.0
007      
ta
008      
230120s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms232113278 $2 doi
035    __
$a (PubMed)36362063
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Gruchot, Joel $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany $1 https://orcid.org/0000000348944679
245    10
$a Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation / $c J. Gruchot, F. Lein, I. Lewen, L. Reiche, V. Weyers, P. Petzsch, P. Göttle, K. Köhrer, HP. Hartung, P. Küry, D. Kremer
520    9_
$a Siponimod (Mayzent®), a sphingosine 1-phosphate receptor (S1PR) modulator which prevents lymphocyte egress from lymphoid tissues, is approved for the treatment of relapsing-remitting and active secondary progressive multiple sclerosis. It can cross the blood-brain barrier (BBB) and selectively binds to S1PR1 and S1PR5 expressed by several cell populations of the central nervous system (CNS) including microglia. In multiple sclerosis, microglia are a key CNS cell population moving back and forth in a continuum of beneficial and deleterious states. On the one hand, they can contribute to neurorepair by clearing myelin debris, which is a prerequisite for remyelination and neuroprotection. On the other hand, they also participate in autoimmune inflammation and axonal degeneration by producing pro-inflammatory cytokines and molecules. In this study, we demonstrate that siponimod can modulate the microglial reaction to lipopolysaccharide-induced pro-inflammatory activation.
650    _2
$a lidé $7 D006801
650    _2
$a mikroglie $x metabolismus $7 D017628
650    _2
$a benzylové sloučeniny $x farmakologie $7 D001593
650    12
$a azetidiny $x farmakologie $x metabolismus $7 D001384
650    12
$a roztroušená skleróza $x metabolismus $7 D009103
655    _2
$a časopisecké články $7 D016428
700    1_
$a Lein, Ferdinand $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany
700    1_
$a Lewen, Isabel $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany
700    1_
$a Reiche, Laura $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany $1 https://orcid.org/0000000223589925
700    1_
$a Weyers, Vivien $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany
700    1_
$a Petzsch, Patrick $u Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich-Heine-University, D-40225 Dusseldorf, Germany $1 https://orcid.org/0000000283555524
700    1_
$a Göttle, Peter $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany
700    1_
$a Köhrer, Karl $u Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich-Heine-University, D-40225 Dusseldorf, Germany $1 https://orcid.org/0000000336442022
700    1_
$a Hartung, Hans-Peter $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany $u Brain and Mind Center, University of Sydney, Sydney, NSW 2050, Australia $u Department of Neurology, Palacky University Olomouc, 77146 Olomouc, Czech Republic
700    1_
$a Küry, Patrick $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany $1 https://orcid.org/0000000226541126
700    1_
$a Kremer, David $u Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 23, č. 21 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36362063 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131150749 $b ABA008
999    __
$a ok $b bmc $g 1891617 $s 1184288
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 23 $c 21 $e 20221031 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace