Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

The Effect of an Extract and Fractions of Date Pits on Some Plasma Constituents, Reproductive Hormones, and Testicular Histology in Male Mice

M. Al Za'abi, BH. Ali, H. Ali, P. Manoj, M. Ashique, A. Nemmar, L. Cahlíková

. 2022 ; 2022 (-) : 4102960. [pub] 20221025

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22032997

Pits of dates (Phoenix dactylifera L.) have numerous nutritional benefits that could have wide-ranging applications. This study aimed to examine the effects of administering three extracts from powdered date pits on some basic physiological parameters, plasma constituents, reproductive hormones, and testicular histology in CD1 male mice. Three groups received doses of 100 mg/kg/day of lyophilized extract, a nonpolar fraction, and a polar fraction of date pits by oral gavage for 28 consecutive days. For the control, one group was administered a 1 mL/kg concentration of distilled water. The three different extracts significantly increased the plasma testosterone level but showed no significant effect on estradiol or luteinizing hormone levels, except for estradiol reduction in the polar extract group. The measured physiological or biochemical parameters or testicular histology also demonstrated no significant differences between the control mice and those mice treated with the three extracts, except for reductions in plasma urea in all extracts and in total protein in the nonpolar extract. Therefore, date pit extracts may potentially be used as a safe and effective dietary supplement. However, further investigation is needed.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032997
003      
CZ-PrNML
005      
20230131151209.0
007      
ta
008      
230120s2022 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2022/4102960 $2 doi
035    __
$a (PubMed)36330351
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Al Za'abi, Mohammed $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman $1 https://orcid.org/0000000220191022
245    14
$a The Effect of an Extract and Fractions of Date Pits on Some Plasma Constituents, Reproductive Hormones, and Testicular Histology in Male Mice / $c M. Al Za'abi, BH. Ali, H. Ali, P. Manoj, M. Ashique, A. Nemmar, L. Cahlíková
520    9_
$a Pits of dates (Phoenix dactylifera L.) have numerous nutritional benefits that could have wide-ranging applications. This study aimed to examine the effects of administering three extracts from powdered date pits on some basic physiological parameters, plasma constituents, reproductive hormones, and testicular histology in CD1 male mice. Three groups received doses of 100 mg/kg/day of lyophilized extract, a nonpolar fraction, and a polar fraction of date pits by oral gavage for 28 consecutive days. For the control, one group was administered a 1 mL/kg concentration of distilled water. The three different extracts significantly increased the plasma testosterone level but showed no significant effect on estradiol or luteinizing hormone levels, except for estradiol reduction in the polar extract group. The measured physiological or biochemical parameters or testicular histology also demonstrated no significant differences between the control mice and those mice treated with the three extracts, except for reductions in plasma urea in all extracts and in total protein in the nonpolar extract. Therefore, date pit extracts may potentially be used as a safe and effective dietary supplement. However, further investigation is needed.
650    _2
$a myši $7 D051379
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a zvířata $7 D000818
650    12
$a rostlinné extrakty $x farmakologie $x terapeutické užití $7 D010936
650    _2
$a testis $7 D013737
650    12
$a Phoeniceae $7 D065749
650    _2
$a estradiol $x farmakologie $7 D004958
655    _2
$a časopisecké články $7 D016428
700    1_
$a Ali, Badreldin H $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman $1 https://orcid.org/0000000164916278
700    1_
$a Ali, Haytham $u Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman $1 https://orcid.org/0000000232739593
700    1_
$a Manoj, Priyadarsini $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
700    1_
$a Ashique, Mohammed $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
700    1_
$a Nemmar, Abderrahim $u Department of Physiology, College of Medicine and Health Sciences, UAE University, Al Ain, UAE $1 https://orcid.org/0000000206991015
700    1_
$a Cahlíková, Lucie $u ADINACO Research Group, Faculty of Pharmacy, Charles University, Prague, Czech Republic
773    0_
$w MED00181094 $t TheScientificWorldJournal $x 1537-744X $g Roč. 2022, č. - (2022), s. 4102960
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36330351 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131151205 $b ABA008
999    __
$a ok $b bmc $g 1891640 $s 1184332
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 2022 $c - $d 4102960 $e 20221025 $i 1537-744X $m TheScientificWorldJournal $n ScientificWorldJournal $x MED00181094
LZP    __
$a Pubmed-20230120

Find record

Citation metrics

Archiving options