Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Posttransplant Complications and Genetic Loci Involved in Telomere Maintenance in Heart Transplant Patients

D. Dlouha, J. Vymetalova, S. Novakova, P. Huckova, V. Lanska, JA. Hubacek

. 2022 ; 13 (10) : . [pub] 20221014

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22033062

Reaching critically short telomeres induces cellular senescence and ultimately cell death. Cellular senescence contributes to the loss of tissue function. We aimed to determine the association between variants within genes involved in telomere length maintenance, posttransplant events, and aortic telomere length in heart transplant patients. DNA was isolated from paired aortic samples of 383 heart recipients (age 50.7 ± 11.9 years) and corresponding donors (age 38.7 ± 12.0 years). Variants within the TERC (rs12696304), TERF2IP (rs3784929 and rs8053257), and OBCF1 (rs4387287) genes were genotyped, and telomere length was measured using qPCR. We identified similar frequencies of genotypes in heart donors and recipients. Antibody-mediated rejection (AMR) was more common (p < 0.05) in carriers of at least one G allele within the TERF2IP locus (rs3784929). Chronic graft dysfunction (CGD) was associated with the TERC (rs12696304) GG donor genotype (p = 0.05). The genetic risk score did not determine posttransplant complication risk prediction. No associations between the analyzed polymorphisms and telomere length were detected in either donor or recipient DNA. In conclusion, possible associations between donor TERF2IP (rs3784929) and AMR and between TERC (rs12696304) and CGD were found. SNPs within the examined genes were not associated with telomere length in transplanted patients.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22033062
003      
CZ-PrNML
005      
20230131151806.0
007      
ta
008      
230120s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/genes13101855 $2 doi
035    __
$a (PubMed)36292740
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Dlouha, Dana $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic $1 https://orcid.org/0000000171671336
245    10
$a Posttransplant Complications and Genetic Loci Involved in Telomere Maintenance in Heart Transplant Patients / $c D. Dlouha, J. Vymetalova, S. Novakova, P. Huckova, V. Lanska, JA. Hubacek
520    9_
$a Reaching critically short telomeres induces cellular senescence and ultimately cell death. Cellular senescence contributes to the loss of tissue function. We aimed to determine the association between variants within genes involved in telomere length maintenance, posttransplant events, and aortic telomere length in heart transplant patients. DNA was isolated from paired aortic samples of 383 heart recipients (age 50.7 ± 11.9 years) and corresponding donors (age 38.7 ± 12.0 years). Variants within the TERC (rs12696304), TERF2IP (rs3784929 and rs8053257), and OBCF1 (rs4387287) genes were genotyped, and telomere length was measured using qPCR. We identified similar frequencies of genotypes in heart donors and recipients. Antibody-mediated rejection (AMR) was more common (p &lt; 0.05) in carriers of at least one G allele within the TERF2IP locus (rs3784929). Chronic graft dysfunction (CGD) was associated with the TERC (rs12696304) GG donor genotype (p = 0.05). The genetic risk score did not determine posttransplant complication risk prediction. No associations between the analyzed polymorphisms and telomere length were detected in either donor or recipient DNA. In conclusion, possible associations between donor TERF2IP (rs3784929) and AMR and between TERC (rs12696304) and CGD were found. SNPs within the examined genes were not associated with telomere length in transplanted patients.
650    _2
$a lidé $7 D006801
650    _2
$a dospělí $7 D000328
650    _2
$a lidé středního věku $7 D008875
650    12
$a telomery $x genetika $7 D016615
650    _2
$a leukocyty $x metabolismus $7 D007962
650    12
$a transplantace srdce $x škodlivé účinky $7 D016027
650    _2
$a genetické lokusy $7 D056426
650    _2
$a DNA $x metabolismus $7 D004247
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vymetalova, Jevgenija $u Cardio Center, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
700    1_
$a Novakova, Sarka $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
700    1_
$a Huckova, Pavlina $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
700    1_
$a Lanska, Vera $u Statistical Unit, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
700    1_
$a Hubacek, Jaroslav Alois $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic $u 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, 140 21 Prague, Czech Republic $1 https://orcid.org/0000000165371353
773    0_
$w MED00174652 $t Genes $x 2073-4425 $g Roč. 13, č. 10 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36292740 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131151802 $b ABA008
999    __
$a ok $b bmc $g 1891684 $s 1184397
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 13 $c 10 $e 20221014 $i 2073-4425 $m Genes $n Genes $x MED00174652
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace