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Nanosponges: An overlooked promising strategy to combat SARS-CoV-2
E. Mostafavi, S. Iravani, RS. Varma
Language English Country England, Great Britain
Document type Journal Article, Review, Research Support, N.I.H., Extramural
Grant support
T32 EB009035
NIBIB NIH HHS - United States
- MeSH
- Antiviral Agents pharmacology therapeutic use MeSH
- COVID-19 Drug Treatment * MeSH
- Humans MeSH
- SARS-CoV-2 * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
Among explored nanomaterials, nanosponge-based systems have exhibited inhibitory effects for the biological neutralization of, and antiviral delivery against, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More studies could pave the path for clarification of their biological neutralization mechanisms as well as the assessment of their long-term biocompatibility and biosafety issues before clinical translational studies. In this review, we discuss recent advances pertaining to antiviral delivery and inhibitory effects of nanosponges against SARS-CoV-2, focusing on important challenges and opportunities. Finally, as promising approaches for recapitulating the complex structure of different organs/tissues of the body, we discuss the use of 3D in vitro models to investigate the mechanism of SARS-CoV-2 infection and to find therapeutic targets to better manage and eradicate coronavirus 2019 (COVID-19).
Department of Medicine Stanford University School of Medicine Stanford CA 94305 USA
Faculty of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences Isfahan Iran
Stanford Cardiovascular Institute Stanford University School of Medicine Stanford CA 94305 USA
References provided by Crossref.org
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