-
Je něco špatně v tomto záznamu ?
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
SR. McWhinney, K. Brosch, VD. Calhoun, B. Crespo-Facorro, NA. Crossley, U. Dannlowski, E. Dickie, LMF. Dietze, G. Donohoe, S. Du Plessis, S. Ehrlich, R. Emsley, P. Furstova, DC. Glahn, A. Gonzalez-Valderrama, D. Grotegerd, L. Holleran, TTJ....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
R01 MH118695
NIMH NIH HHS - United States
R01 MH116147
NIMH NIH HHS - United States
103703
Wellcome Trust - United Kingdom
106469
CIHR - Canada
142255
CIHR - Canada
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- depresivní porucha unipolární * MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mozek MeSH
- obezita MeSH
- schizofrenie * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
Center for the Neurobiology of Learning and Memory University of California Irvine Irvine CA USA
Centro de Investigación Biomédica en Red de Salud Mental Madrid Spain
Charles University 3rd Faculty of Medicine Prague Czech Republic
Computación Avanzada y Ciencia Instituto de Física de Cantabria CSIC Santander Spain
Department of Medicine and Psychiatry School of Medicine University of Cantabria Santander Spain
Department of Neuroscience and Physiology SUNY Upstate Medical University Syracuse NY USA
Department of Pscyhiatry and Psychotherapy University of Lübeck Lübeck Germany
Department of Psychiatry and Behavioral Sciences Boston Children's Hospital Boston MA USA
Department of Psychiatry and Psychotherapy Philipps University Marburg Marburg Germany
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Harvard Medical School Boston MA USA
Department of Psychiatry Jena University Hospital Friedrich Schiller University Jena Jena Germany
Department of Psychiatry School of Medicina Pontificia Universidad Católica de Chile Santiago Chile
Department of Psychiatry School of Medicine University of Sevilla Sevilla Spain
Department of Psychology Georgia State University Atlanta GA USA
Department of Psychology University of Bath Bath UK
Department of Psychosis Studies King's College London London UK
Early Intervention in Psychosis Program Instituto Psiquiátrico 'Dr José Horwitz B ' Santiago Chile
IBiS University Hospital Virgen del Rocio Sevilla Spain
Institute for Translational Psychiatry University of Münster Münster Germany
Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore
National Institute of Mental Health Klecany Czech Republic
Neuroscience Research Australia Randwick NSW Australia
Olin Neuropsychiatry Research Center Institute of Living Hartford CT USA
Psychiatry and Human Behavior University of California Irvine Irvine CA USA
SAMRC Genomics of Brain Disorders Unit Cape Town South Africa
School of Medicine Universidad Finis Terrae Santiago Chile
School of Psychiatry University of New South Wales Sydney NSW Australia
West Region Institute of Mental Health Singapore Singapore
Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22033325
- 003
- CZ-PrNML
- 005
- 20230131151036.0
- 007
- ta
- 008
- 230120s2022 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41380-022-01616-5 $2 doi
- 035 __
- $a (PubMed)35739320
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a McWhinney, Sean R $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
- 245 10
- $a Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals / $c SR. McWhinney, K. Brosch, VD. Calhoun, B. Crespo-Facorro, NA. Crossley, U. Dannlowski, E. Dickie, LMF. Dietze, G. Donohoe, S. Du Plessis, S. Ehrlich, R. Emsley, P. Furstova, DC. Glahn, A. Gonzalez-Valderrama, D. Grotegerd, L. Holleran, TTJ. Kircher, P. Knytl, M. Kolenic, R. Lencer, I. Nenadić, N. Opel, JK. Pfarr, AL. Rodrigue, K. Rootes-Murdy, AJ. Ross, K. Sim, A. Škoch, F. Spaniel, F. Stein, P. Švancer, D. Tordesillas-Gutiérrez, J. Undurraga, J. Váquez-Bourgon, A. Voineskos, E. Walton, TW. Weickert, CS. Weickert, PM. Thompson, TGM. van Erp, JA. Turner, T. Hajek
- 520 9_
- $a Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a schizofrenie $7 D012559
- 650 12
- $a depresivní porucha unipolární $7 D003865
- 650 _2
- $a mozek $7 D001921
- 650 _2
- $a magnetická rezonanční tomografie $x metody $7 D008279
- 650 _2
- $a obezita $7 D009765
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Brosch, Katharina $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany
- 700 1_
- $a Calhoun, Vince D $u Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory University, Atlanta, GA, USA $1 https://orcid.org/0000000190580747
- 700 1_
- $a Crespo-Facorro, Benedicto $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain $u IBiS, University Hospital Virgen del Rocio, Sevilla, Spain $u Department of Psychiatry, School of Medicine, University of Sevilla, Sevilla, Spain
- 700 1_
- $a Crossley, Nicolas A $u Department of Psychiatry, School of Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile $u Department of Psychosis Studies, King's College London, London, UK
- 700 1_
- $a Dannlowski, Udo $u Institute for Translational Psychiatry, University of Münster, Münster, Germany $1 https://orcid.org/0000000206233759
- 700 1_
- $a Dickie, Erin $u Centre for Addiction & Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada $1 https://orcid.org/0000000330289864
- 700 1_
- $a Dietze, Lorielle M F $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
- 700 1_
- $a Donohoe, Gary $u Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland $1 https://orcid.org/0000000330377426
- 700 1_
- $a Du Plessis, Stefan $u Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa $u SAMRC Genomics of Brain Disorders Unit, Cape Town, South Africa
- 700 1_
- $a Ehrlich, Stefan $u Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany $1 https://orcid.org/0000000321324445
- 700 1_
- $a Emsley, Robin $u Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
- 700 1_
- $a Furstova, Petra $u National Institute of Mental Health, Klecany, Czech Republic
- 700 1_
- $a Glahn, David C $u Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA $u Department of Psychiatry, Harvard Medical School, Boston, MA, USA $u Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA
- 700 1_
- $a Gonzalez-Valderrama, Alfonso $u School of Medicine, Universidad Finis Terrae, Santiago, Chile $u Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr. José Horwitz B.', Santiago, Chile
- 700 1_
- $a Grotegerd, Dominik $u Institute for Translational Psychiatry, University of Münster, Münster, Germany
- 700 1_
- $a Holleran, Laurena $u Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland
- 700 1_
- $a Kircher, Tilo T J $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany
- 700 1_
- $a Knytl, Pavel $u National Institute of Mental Health, Klecany, Czech Republic $u Charles University, Third Faculty of Medicine, Prague, Czech Republic
- 700 1_
- $a Kolenic, Marian $u National Institute of Mental Health, Klecany, Czech Republic $u Charles University, Third Faculty of Medicine, Prague, Czech Republic $1 https://orcid.org/0000000223823478
- 700 1_
- $a Lencer, Rebekka $u Institute for Translational Psychiatry, University of Münster, Münster, Germany $u Department of Pscyhiatry and Psychotherapy, University of Lübeck, Lübeck, Germany $1 https://orcid.org/0000000340327297
- 700 1_
- $a Nenadić, Igor $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany
- 700 1_
- $a Opel, Nils $u Institute for Translational Psychiatry, University of Münster, Münster, Germany $u Department of Psychiatry, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany
- 700 1_
- $a Pfarr, Julia-Katharina $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany
- 700 1_
- $a Rodrigue, Amanda L $u Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA $u Department of Psychiatry, Harvard Medical School, Boston, MA, USA $1 https://orcid.org/0000000234036349
- 700 1_
- $a Rootes-Murdy, Kelly $u Department of Psychology, Georgia State University, Atlanta, GA, USA
- 700 1_
- $a Ross, Alex J $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
- 700 1_
- $a Sim, Kang $u West Region, Institute of Mental Health, Singapore, Singapore $u Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore $u Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
- 700 1_
- $a Škoch, Antonín $u National Institute of Mental Health, Klecany, Czech Republic $u Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 700 1_
- $a Spaniel, Filip $u National Institute of Mental Health, Klecany, Czech Republic $u Charles University, Third Faculty of Medicine, Prague, Czech Republic $1 https://orcid.org/000000033479696X
- 700 1_
- $a Stein, Frederike $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany $1 https://orcid.org/0000000250526022
- 700 1_
- $a Švancer, Patrik $u National Institute of Mental Health, Klecany, Czech Republic $u Charles University, Third Faculty of Medicine, Prague, Czech Republic
- 700 1_
- $a Tordesillas-Gutiérrez, Diana $u Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain $u Computación Avanzada y Ciencia, Instituto de Física de Cantabria, CSIC, Santander, Spain $1 https://orcid.org/0000000314583932
- 700 1_
- $a Undurraga, Juan $u Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr. José Horwitz B.', Santiago, Chile $u Department of Neurology and Psychiatry. Faculty of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago, Chile $1 https://orcid.org/0000000169582369
- 700 1_
- $a Váquez-Bourgon, Javier $u Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain $u Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain $u Department of Psychiatry, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain $1 https://orcid.org/0000000254783376
- 700 1_
- $a Voineskos, Aristotle $u Centre for Addiction & Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- 700 1_
- $a Walton, Esther $u Department of Psychology, University of Bath, Bath, UK $1 https://orcid.org/0000000209352200
- 700 1_
- $a Weickert, Thomas W $u Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA $u Neuroscience Research Australia, Randwick, NSW, Australia $1 https://orcid.org/000000026408718X
- 700 1_
- $a Weickert, Cynthia Shannon $u Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA $u Neuroscience Research Australia, Randwick, NSW, Australia $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
- 700 1_
- $a Thompson, Paul M $u Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
- 700 1_
- $a van Erp, Theo G M $u Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA $u Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA $1 https://orcid.org/0000000224652797
- 700 1_
- $a Turner, Jessica A $u Department of Psychology, Georgia State University, Atlanta, GA, USA $1 https://orcid.org/0000000300768434
- 700 1_
- $a Hajek, Tomas $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. tomas.hajek@dal.ca $u National Institute of Mental Health, Klecany, Czech Republic. tomas.hajek@dal.ca $1 https://orcid.org/0000000302818458
- 773 0_
- $w MED00008047 $t Molecular psychiatry $x 1476-5578 $g Roč. 27, č. 9 (2022), s. 3731-3737
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35739320 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230120 $b ABA008
- 991 __
- $a 20230131151032 $b ABA008
- 999 __
- $a ok $b bmc $g 1891863 $s 1184660
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2022 $b 27 $c 9 $d 3731-3737 $e 20220614 $i 1476-5578 $m Molecular psychiatry $n Mol Psychiatry $x MED00008047
- GRA __
- $a R01 MH118695 $p NIMH NIH HHS $2 United States
- GRA __
- $a R01 MH116147 $p NIMH NIH HHS $2 United States
- GRA __
- $a 103703 $p Wellcome Trust $2 United Kingdom
- GRA __
- $a 106469 $p CIHR $2 Canada
- GRA __
- $a 142255 $p CIHR $2 Canada
- LZP __
- $a Pubmed-20230120
