Recently, more and more efforts are directed towards developing new imaging and drug-delivery options based on various nanoparticles, exploiting their unique properties. Here, ultra-small gold nanoparticles functionalized with widely used polyethylene glycol and its amine-terminated form were tested in respect of their potential interactions with human immune cells (cell line and primary cells). The results showed that differently terminated ultrasmall gold nanoparticles represent an interesting theranostic platform as they are harmless to immune cells (not inducing cytotoxicity and severe immune response) and on the other hand, they can serve as imaging and/or drug delivery agents using e.g. monocytes/ macrophages as "Trojan horses" to deliver these nanoparticles across the blood-brain barrier and diagnose or treat pathologies of the central nervous system.

Biomedical Centre Faculty of Medicine in Pilsen Charles University Czech Republic

Department of Solid State Engineering University of Chemistry and Technology Prague Czech Republic

Institute of Immunology and Microbiology 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic

Institute of Pathological Physiology 1st Faculty of Medicine Charles University Czech Republic

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$a Bělinová, T. $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Czech Republic

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$a Ultra-Small Gold Nanoparticles with Mild Immunomodulatory Activity as a Potential Tool for Bio-Applications / $c T. Bělinová, P. Javorová, HY. Nguyenová, A. Řezníčková, Z. Humlová, M. Hubálek Kalbáčová

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$a Recently, more and more efforts are directed towards developing new imaging and drug-delivery options based on various nanoparticles, exploiting their unique properties. Here, ultra-small gold nanoparticles functionalized with widely used polyethylene glycol and its amine-terminated form were tested in respect of their potential interactions with human immune cells (cell line and primary cells). The results showed that differently terminated ultrasmall gold nanoparticles represent an interesting theranostic platform as they are harmless to immune cells (not inducing cytotoxicity and severe immune response) and on the other hand, they can serve as imaging and/or drug delivery agents using e.g. monocytes/ macrophages as "Trojan horses" to deliver these nanoparticles across the blood-brain barrier and diagnose or treat pathologies of the central nervous system.

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