Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis

P. Hradilek, KZ. Revendova, J. Horakova, R. Bunganic, O. Pelisek, D. Zeman, P. Hanzlikova, P. Kusnierova

. 2023 ; 167 (1) : 30-35. [pub] 20230125

Jazyk angličtina Země Česko

Typ dokumentu pozorovací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23002202

AIM: The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic lumbar puncture can predict the course of multiple sclerosis (MS) in terms of relapses, higher expanded disability status scale (EDSS) and magnetic resonance imaging (MRI) activity. METHODS: We conducted a single-centre prospective observational cohort study at the MS center, University Hospital Ostrava, Czech Republic. CSF NfL (cNfL) and CXCL13 concentrations were examined (ELISA method) in patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) at the time of diagnostic lumbar puncture. RESULTS: A total of 44 patients with CIS or early RRMS were enrolled, 31 (70.5%) of whom were women. The median age at the time of CSF sampling was 31.21 years (IQR 25.43-39.32), and the follow-up period was 54.6 months (IQR 44.03-59.48). In the simple and multiple logistic regression models, CXCL13 levels did not predict relapses, MRI activity or EDSS > 2.5. Similarly, cNfL concentrations did not predict relapses or MRI activity in either model. In the multiple regression, higher cNfL levels were associated with reaching EDSS > 2.5 (odds ratio [OR] 1.002, 95% confidence interval [CI] 1.000 to 1.003). CONCLUSIONS: Our data did not confirm cNfL and/or CXCL13 CSF levels were predictive factors for disease activity such as relapses and MRI activity at the time of diagnostic lumbar puncture in patients with RRMS. While cNfL CSF levels predicted higher disability only after adjustment for other known risk factors, elevated CSF CXCL13 did not predict higher disability at all.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23002202
003      
CZ-PrNML
005      
20230517134554.0
007      
ta
008      
230406s2023 xr f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2023.002 $2 doi
035    __
$a (PubMed)36695545
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hradílek, Pavel $u Department of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $u Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic $7 xx0076908
245    10
$a Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis / $c P. Hradilek, KZ. Revendova, J. Horakova, R. Bunganic, O. Pelisek, D. Zeman, P. Hanzlikova, P. Kusnierova
520    9_
$a AIM: The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic lumbar puncture can predict the course of multiple sclerosis (MS) in terms of relapses, higher expanded disability status scale (EDSS) and magnetic resonance imaging (MRI) activity. METHODS: We conducted a single-centre prospective observational cohort study at the MS center, University Hospital Ostrava, Czech Republic. CSF NfL (cNfL) and CXCL13 concentrations were examined (ELISA method) in patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) at the time of diagnostic lumbar puncture. RESULTS: A total of 44 patients with CIS or early RRMS were enrolled, 31 (70.5%) of whom were women. The median age at the time of CSF sampling was 31.21 years (IQR 25.43-39.32), and the follow-up period was 54.6 months (IQR 44.03-59.48). In the simple and multiple logistic regression models, CXCL13 levels did not predict relapses, MRI activity or EDSS > 2.5. Similarly, cNfL concentrations did not predict relapses or MRI activity in either model. In the multiple regression, higher cNfL levels were associated with reaching EDSS > 2.5 (odds ratio [OR] 1.002, 95% confidence interval [CI] 1.000 to 1.003). CONCLUSIONS: Our data did not confirm cNfL and/or CXCL13 CSF levels were predictive factors for disease activity such as relapses and MRI activity at the time of diagnostic lumbar puncture in patients with RRMS. While cNfL CSF levels predicted higher disability only after adjustment for other known risk factors, elevated CSF CXCL13 did not predict higher disability at all.
650    _2
$a lidé $7 D006801
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a dospělí $7 D000328
650    _2
$a mužské pohlaví $7 D008297
650    12
$a roztroušená skleróza $x diagnóza $x mozkomíšní mok $7 D009103
650    _2
$a prospektivní studie $7 D011446
650    _2
$a intermediární filamenta $7 D007382
650    _2
$a biologické markery $x mozkomíšní mok $7 D015415
650    12
$a relabující-remitující roztroušená skleróza $x diagnostické zobrazování $x mozkomíšní mok $7 D020529
650    _2
$a progrese nemoci $7 D018450
650    _2
$a recidiva $7 D012008
650    _2
$a chemokin CXCL13 $7 D054382
655    _2
$a pozorovací studie $7 D064888
655    _2
$a časopisecké články $7 D016428
700    1_
$a Revendová, Kamila $u Department of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $u Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic $7 xx0269360
700    1_
$a Horáková, Jana $u Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic $7 xx0237791
700    1_
$a Bunganic, Radovan $u Department of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $u Department of Neurology, University Hospital Ostrava, Ostrava, Czech Republic
700    1_
$a Pelisek, Ondrej $u Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Zeman, David, $u Department of Laboratory Medicine, University Hospital Brno, Brno, Czech Republic $d 1972- $7 mzk2018988719
700    1_
$a Hanzlíková, Pavla $u Department of Imaging Methods, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $7 xx0227542
700    1_
$a Kušnierová, Pavlína, $u Department of Clinical Biochemistry, Institute of Laboratory Medicine, University Hospital Ostrava, Ostrava, Czech Republic $u Institute of Laboratory Medicine, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $d 1978- $7 xx0140526
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia $x 1804-7521 $g Roč. 167, č. 1 (2023), s. 30-35
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36695545 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y p $z 0
990    __
$a 20230406 $b ABA008
991    __
$a 20230517134549 $b ABA008
999    __
$a ok $b bmc $g 1933530 $s 1188408
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 167 $c 1 $d 30-35 $e 20230125 $i 1804-7521 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK198 $a Pubmed-20230406

Najít záznam

Citační ukazatele

Možnosti archivace