• Je něco špatně v tomto záznamu ?

Probiotic Bacteria Cannot Mitigate the Adverse Effects of Radioactive Iodine-131 Treatment

SMJ. Mortazavi, S. Nowroozi, M. Haghani, Z. Zarrini-Monfared, F. Gheisari, L. Sihver

. 2023 ; 15 (3) : . [pub] 20230125

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23003094

Thyroid carcinoma is the most common cancer of the endocrine system, accounting for 12% of all cancer cases in adolescents in the United States. Radioiodine therapy plays a key role in differentiated thyroid cancer (DTC) treatment. This double-blind, randomized, placebo-controlled clinical trial was aimed at evaluating the effect of probiotics supplementation in reducing the acute side-effects of radioiodine therapy in PTC patients. Fifty-six patients were randomly divided into four groups: one placebo and three intervention groups. The probiotics product used in this study was LactoCare (ZistTakhmir Co., Tehran, Iran), a multi-strain commercially available symbiotic containing 12 strains of probiotic species including Lactobacillus strains, Bifidobacteria strains, and Streptococcus thermophilus, plus Fructo-oligosaccharides as the prebiotic. Group 0 was our placebo group (no probiotics), while the other three groups received probiotics capsules for 2/4 days, starting only 2 days prior to radioiodine therapy, only 4 days after radioiodine therapy or 2 days prior and 4 days after radioiodine therapy. Six patients were withdrawn during the study because of poor compliance or at their own request. The symptoms reported by patients including data about the incidence and duration of each complication were recorded. The probiotics' effectiveness was confirmed for dry mouth and taste loss or change when it was administered prior to the radioiodine treatment. The benefit was not confirmed for other radiation-induced complications such as pain and swelling in the neck, nausea and vomiting, salivary gland swelling, and diarrhea. Further large-scale clinical trials are warranted to improve our knowledge in this quickly evolving field.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23003094
003      
CZ-PrNML
005      
20230421095925.0
007      
ta
008      
230413s2023 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/cancers15030740 $2 doi
035    __
$a (PubMed)36765697
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Mortazavi, Seyed Mohammad Javad $u Medical Physics and Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
245    10
$a Probiotic Bacteria Cannot Mitigate the Adverse Effects of Radioactive Iodine-131 Treatment / $c SMJ. Mortazavi, S. Nowroozi, M. Haghani, Z. Zarrini-Monfared, F. Gheisari, L. Sihver
520    9_
$a Thyroid carcinoma is the most common cancer of the endocrine system, accounting for 12% of all cancer cases in adolescents in the United States. Radioiodine therapy plays a key role in differentiated thyroid cancer (DTC) treatment. This double-blind, randomized, placebo-controlled clinical trial was aimed at evaluating the effect of probiotics supplementation in reducing the acute side-effects of radioiodine therapy in PTC patients. Fifty-six patients were randomly divided into four groups: one placebo and three intervention groups. The probiotics product used in this study was LactoCare (ZistTakhmir Co., Tehran, Iran), a multi-strain commercially available symbiotic containing 12 strains of probiotic species including Lactobacillus strains, Bifidobacteria strains, and Streptococcus thermophilus, plus Fructo-oligosaccharides as the prebiotic. Group 0 was our placebo group (no probiotics), while the other three groups received probiotics capsules for 2/4 days, starting only 2 days prior to radioiodine therapy, only 4 days after radioiodine therapy or 2 days prior and 4 days after radioiodine therapy. Six patients were withdrawn during the study because of poor compliance or at their own request. The symptoms reported by patients including data about the incidence and duration of each complication were recorded. The probiotics' effectiveness was confirmed for dry mouth and taste loss or change when it was administered prior to the radioiodine treatment. The benefit was not confirmed for other radiation-induced complications such as pain and swelling in the neck, nausea and vomiting, salivary gland swelling, and diarrhea. Further large-scale clinical trials are warranted to improve our knowledge in this quickly evolving field.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Nowroozi, Saba $u School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
700    1_
$a Haghani, Masoud $u Radiology and Radiobiology Department, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
700    1_
$a Zarrini-Monfared, Zinat $u Department of Medical Physics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran 19835-178, Iran $1 https://orcid.org/0000000249891647
700    1_
$a Gheisari, Farshid $u Nuclear Medicine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
700    1_
$a Sihver, Lembit $u Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, 180 00 Prague, Czech Republic $u Technische Universität Wien, Atominstitut, 1020 Vienna, Austria
773    0_
$w MED00173178 $t Cancers $x 2072-6694 $g Roč. 15, č. 3 (2023)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36765697 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230413 $b ABA008
991    __
$a 20230421095918 $b ABA008
999    __
$a ok $b bmc $g 1922770 $s 1189301
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 15 $c 3 $e 20230125 $i 2072-6694 $m Cancers $n Cancers $x MED00173178
LZP    __
$a Pubmed-20230413

Najít záznam

Citační ukazatele

Možnosti archivace